San Francisco 49ers vs Arizona Cardinals Odds, Week 3, 2025

#1 QB

Brock Purdy: Officially limited in return to practice

Sep 17th

Purdy (left shoulder/toe) officially was a limited practice participant Wednesday, Matt Barrows of The Athletic reports.

#2 LG

Ben Bartch: Lands on IR

Sep 17th

Bartch (ankle) was placed on injured reserve Wednesday, Noah Furtado of the San Francisco Chronicle reports.

#1 WR

Jauan Jennings: No practice Wednesday

Sep 17th

Jennings (ankle/shoulder) officially didn't practice Wednesday, Matt Barrows of The Athletic reports.

#8 WR

Brandon Aiyuk: Spotted running

Sep 17th

Aiyuk (knee) did some running while his teammates were practicing Wednesday, Nick Wagoner of ESPN.com reports.

#3 TE

Brayden Willis: Bumps to active roster

Sep 17th

The 49ers signed Willis to the active roster from the practice squad Wednesday.

#2 FS

Siran Neal: Enters concussion protocol

Sep 15th

Neal has entered the league's concussion protocol following the 49ers' Week 2 win over the Saints, Nick Wagoner of ESPN.com reports.

#2 LT

Spencer Burford: Dealing with knee injury

Sep 15th

Burford suffered a knee injury in Sunday's 26-21 win over the Saints, David Lombardi of SFStandard.com reports.

#1 K

Eddy Pineiro: Misses PAT in Niners debut

Sep 15th

Pineiro went 2-for-3 on extra-point attempts and made both of his field-goal tries during the 49ers' 26-21 win over the Saints on Sunday.

#4 WR

Marquez Valdes-Scantling: Logs nine snaps on offense

Sep 15th

Valdes-Scantling failed to bring in his only target in Sunday's 26-21 win over the Saints.

#1 TE

Jake Tonges: Nabs four receptions Sunday

Sep 15th

Tonges finished with four receptions (on five targets) for 31 yards in Sunday's 26-21 win over the Saints.

#2 TE

Luke Farrell: Scores first TD of career

Sep 15th

Farrell brought in two of three targets for 15 yards and a touchdown in Sunday's 26-21 win over the Saints.

#1 MLB

Fred Warner: Does it all vs. Saints

Sep 15th

Warner recorded 11 total tackles (seven solo), one pass defended, one forced fumble and one fumble recovery in Sunday's 26-21 win over the Saints.

#3 RB

Isaac Guerendo: No carries in Week 2 win

Sep 15th

Guerendo returned two kickoffs for 47 yards and was not used on offense in Sunday's 26-21 win over the Saints.

#1 RDE

Nick Bosa: Productive again in Week 2

Sep 15th

Bosa recorded nine total tackles (three solo), including 1.0 sacks, during Sunday's 26-21 win over the Saints.

#2 RB

Brian Robinson: Handles seven touches Sunday

Sep 15th

Robinson rushed six times for 20 yards and caught his only target for a loss of one yard in Sunday's 26-21 win over New Orleans.

#3 WR

Kendrick Bourne: Three catches in return to Niners

Sep 14th

Bourne caught all three of his targets for 32 yards in Sunday's 26-21 win over the Saints.

#2 WR

Ricky Pearsall: Four grabs in Week 2 win

Sep 14th

Pearsall caught four of six targets for 56 yards in Sunday's 26-21 win over the Saints. He also rushed once for minus-4 yards.

#2 QB

Mac Jones: Tosses three TDs in win

Sep 14th

Jones completed 26 of 39 passes for 279 yards and three touchdowns in Sunday's 26-21 win over the Saints. He added six rushing yards on six carries.

#1 RB

Christian McCaffrey: Finds end zone in Week 2 win

Sep 14th

McCaffrey carried the ball 13 times for 55 yards and caught six of seven targets for 52 yards and a touchdown in Sunday's 26-21 win over the Saints.

#1 FB

Kyle Juszczyk: Won't return vs. New Orleans

Sep 14th

Juszczyk has been ruled out for the rest of Sunday's game against the Saints due to a concussion, Jennifer Lee Chan of NBC Sports Bay Area reports.

#4 RB

Jordan James: Healthy scratch vs. NOLA

Sep 14th

James (coach's decision) is inactive for Sunday's game against the Saints, Briana Jeannel of the 49ers' official site reports.

#1 LT

Trent Williams: Suiting up Sunday

Sep 14th

Williams (knee) is active for Sunday's matchup with the Saints, Briana Jeannel of the 49ers' official site reports.

#6 WR

Jordan Watkins: Pro debut pushed back

Sep 14th

Watkins (coach's decision) is inactive for Sunday's game at New Orleans, Briana Jeannel of the 49ers' official site reports.

#2 LDE

Yetur Gross-Matos: Returns to practice Thursday

Sep 11th

Gross-Matos (knee) was a limited participant in Thursday's practice, Vic Tafur of The Athletic reports.

#4 TE

George Kittle: Move to IR official

Sep 9th

The 49ers placed Kittle (hamstring) on injured reserve Tuesday.

#5 WR

Skyy Moore: Handles return duties for SF

Sep 8th

Moore did not receive a target and returned five combined kicks for 63 yards in Sunday's 17-13 win over Seattle.

#1 RT

Colton McKivitz: Inks extension with San Francisco

Sep 8th

McKivitz signed a three-year, $45 million extension with the 49ers on Monday, Adam Schefter of ESPN reports.

#1 SS

Marques Sigle: Gets starting nod Week 1

Sep 7th

Sigle will be the 49ers' starting safety against the Seahawks on Sunday, Matt Maiocco of NBC Sports Bay Area reports.

#1 RG

Dominick Puni: Ready to face Seahawks

Sep 5th

Puni (knee) does not have an injury designation ahead of Sunday's game against the Seahawks, Michael-Shawn Dugar of The Athletic reports.