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Cardinals vs 49ers Odds, Lines, Spreads & Totals 2025

49ers
25.8 Pts
Cardinals
22.8 Pts
Sunday November 16, 2025 at 4:05 PM ET
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49ers Injury Report
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Cardinals Injury Report
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49ers Lineup
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Cardinals Lineup
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49ers News
#1 RCB
Deommodore Lenoir: Appears on injury report
Nov 13th
Lenoir (calf) was a limited participant in practice Thursday, Eric Branch of the San Francisco Chronicle reports.
#2 WR
Ricky Pearsall: Another limited session
Nov 13th
Pearsall (knee) practiced in a limited capacity Thursday, Eric Branch of the San Francisco Chronicle reports.
#1 QB
Brock Purdy: Full practice Thursday, to start Sunday
Nov 13th
Purdy (toe) practiced in full Thursday, Matt Barrows of The Athletic reports. Afterward, coach Kyle Shanahan announced on KNBR San Francisco that Purdy was in line to start Sunday's contest at Arizona.
#1 DT2
Alfred Collins: Back at practice to begin week
Nov 12th
Collins (hip) was a limited practice participant Wednesday, Cam Inman of The San Jose Mercury News reports.
#1 WLB
Dee Winters: Still managing knee issue
Nov 12th
Winters (knee) was a limited practice participant Wednesday, Cam Inman of The San Jose Mercury News reports.
#1 SCB
Upton Stout: Makes four stops in Week 10 loss
Nov 11th
Stout secured four tackles (one solo) against the Rams in Sunday's loss.
#1 FS
Malik Mustapha: Posts eight stops in Week 10 loss
Nov 11th
Mustapha notched eight tackles (four solo) in Sunday's loss to the Rams.
#1 SS
Ji'Ayir Brown: Notches double-digit tackles
Nov 10th
Brown recorded 10 tackles (three solo) and one pass defensed in Sunday's 42-26 loss to the Rams.
#1 MLB
Tatum Bethune: Double-digit stops again
Nov 10th
Bethune recorded 10 tackles (two solo), including one tackle for loss, in Sunday's 42-26 loss to the Rams.
#7 WR
Brandon Aiyuk: Unlikely to practice this week
Nov 10th
Head coach Kyle Shanahan said Monday that the 49ers don't intend to open Aiyuk's (knee) practice window this week, Nick Wagoner of ESPN.com reports.
#2 TE
Luke Farrell: Hits pay dirt in loss
Nov 10th
Farrell had two receptions on as many targets for 15 yards and a touchdown in Sunday's 42-26 loss to the Rams.
#6 WR
Jordan Watkins: No targets against Rams
Nov 10th
Watkins was limited to three snaps on offense (five percent) and did not garner a target in Sunday's 42-26 loss to the Rams.
#5 WR
Skyy Moore: Reception in consecutive games
Nov 10th
Moore secured his only target for 18 yards in Sunday's 42-26 loss to the Rams.
#4 WR
Demarcus Robinson: Gets involved Sunday
Nov 10th
Robinson had three receptions (on four targets) for 34 yards in Sunday's 42-26 loss to the Rams.
#3 WR
Kendrick Bourne: Held to one catch in Sunday's start
Nov 10th
Bourne caught his only target for 19 yards in Sunday's 42-26 loss to the Rams.
#2 RB
Brian Robinson: Scores in consecutive games
Nov 9th
Robinson took eight carries for 41 yards and a touchdown while catching his only target for four yards in Sunday's 42-26 loss to the Rams.
#1 TE
George Kittle: Best fantasy game this season
Nov 9th
Kittle secured all nine of his targets for 84 yards and a touchdown in Sunday's 42-26 loss to the Rams.
#1 WR
Jauan Jennings: Best line since Week 2
Nov 9th
Jennings corralled six of nine targets for 71 yards and a touchdown while losing a fumble in Sunday's 42-26 loss to the Rams.
#2 QB
Mac Jones: Strong fantasy performance Sunday
Nov 9th
Jones completed 33 of 39 pass attempts for 319 yards, three touchdowns and one interception while gaining three yards on one rush attempt in Sunday's 42-26 loss to the Rams.
#1 RB
Christian McCaffrey: Grinds for 96 total yards Sunday
Nov 9th
McCaffrey rushed 12 times for 30 yards and brought in eight of 10 targets for 66 yards in Sunday's 42-26 loss to the Rams.
#1 K
Eddy Pineiro: Limited workload in loss
Nov 9th
Pineiro did not attempt a field goal and went 2-for-3 on extra-point tries in Sunday's 42-26 loss to the Rams.
#2 LDE
Keion White: Cleared to play vs. Rams
Nov 9th
White (groin) is active for Sunday's game against the Rams, Briana Jeannel of the 49ers' official site reports.
#1 LG
Ben Bartch: Officially returning in Week 10
Nov 9th
Bartch (ankle) is active for Sunday's battle against the Rams, Briana Jeannel of the 49ers' official site reports.
#1 LDT
Kalia Davis: Will play Week 10
Nov 9th
Davis (ankle) is active for Sunday's game against the Rams, Briana Jeannel of the 49ers' official site reports.
#4 RDE
Mykel Williams: Sent to injured reserve
Nov 8th
The 49ers placed Williams (knee) on injured reserve Saturday.
#1 C
Jake Brendel: Returning to action in Week 10
Nov 7th
Brendel (hamstring) does not have an injury designation for Sunday's battle against the Rams, Nick Wagoner of ESPN.com reports.
#1 LDE
Bryce Huff: Cleared to return Week 10
Nov 7th
Huff (hamstring) does not carry an injury designation into Sunday's game against the Rams, Matt Barrows of The Athletic reports.
#2 DT2
Jordan Elliott: Cleared to play Week 9
Nov 2nd
Elliott (ankle) is active for Sunday's game against the Giants, Briana Jeannel of the 49ers' official site reports.
#2 LG
Spencer Burford: Officially cleared for Week 9
Nov 2nd
Burford (knee) is active for Sunday's game against the Giants, Briana Jeannel of the 49ers' official site reports.
#2 LT
Spencer Burford: Officially cleared for Week 9
Nov 2nd
Burford (knee) is active for Sunday's game against the Giants, Briana Jeannel of the 49ers' official site reports.
#2 FS
Marques Sigle: Healthy scratch Sunday
Nov 2nd
Sigle (coach's decision) is inactive for Sunday's game against the Giants, Briana Jeannel of the 49ers' official site reports.
#1 RDE
Sam Okuayinonu: Good to go Sunday
Nov 2nd
Okuayinonu (ankle) is active for Sunday's matchup with the Giants, Briana Jeannel of the 49ers' official site reports.
#3 RDE
Yetur Gross-Matos: Lands on IR
Nov 1st
Gross-Matos (knee) was placed on injured reserve Saturday.
ARI
Cardinals News
#1 LG
Evan Brown: Limited in Thursday's practice
Nov 13th
Brown (foot) was limited during Thursday's practice, Zach Gershman of the Cardinals' official site reports.
#1 RG
Will Hernandez: Logs limited practice Thursday
Nov 13th
Hernandez (knee) was a limited participant in Thursday's practice, Zach Gershman of the Cardinals' official site reports.
#3 SLB
BJ Ojulari: Limited in Thursday's practice
Nov 13th
Ojulari (knee) was a limited participant in Thursday's practice, Zach Gershman of the Cardinals' official site reports.
#2 SLB
Baron Browning: Doesn't practice Thursday
Nov 13th
Browning (concussion) did not practice Thursday, Zach Gershman of the Cardinals' official site reports.
#2 DT2
Walter Nolen: Remains limited Thursday
Nov 13th
Nolen (knee) was a limited participant in Thursday's practice, Zach Gershman of the Cardinals' official site reports.
#2 SS
Dadrion Taylor-Demerson: Misses Thursday's practice
Nov 13th
Taylor-Demerson (ankle) did not participate in Thursday's practice, Zach Gershman of the Cardinals' official site reports.
#1 LCB
Will Johnson: Doesn't practice Thursday
Nov 13th
Johnson (back) did not participate in Thursday's practice, Zach Gershman of the Cardinals' official site reports.
#1 RCB
Max Melton: Dons non-contact jersey Thursday
Nov 13th
Melton (concussion) was a limited participant in Thursday's practice, Zach Gershman of the Cardinals' official site reports.
#4 WR
Xavier Weaver: On track to return Week 11
Nov 13th
Weaver (ankle) was a full participant in Thursday's practice, Zach Gershman of the Cardinals' official site reports.
#1 RB
Bam Knight: Another limited showing
Nov 13th
Knight (ankle) practiced on a limited basis Thursday, Josh Weinfuss of ESPN.com reports.
#2 LG
Hayden Conner: Practice window opens
Nov 13th
The Cardinals announced Thursday that Conner (knee) has been designated for return from IR.
#1 RT
Jonah Williams: No practice Wednesday
Nov 12th
Williams (shoulder) was estimated to have not practiced Wednesday, Zach Gershman of the Cardinals' official site reports.
#5 WR
Andre Baccellia: Signed to Arizona's active roster
Nov 12th
The Cardinals signed Baccellia from the practice squad to the active roster Wednesday.
#1 MLB
Mack Wilson: Ruled out again
Nov 12th
Wilson (ribs) has been ruled out for Sunday's matchup against the 49ers, Tyler Drake of ArizonaSports.com reports.
#7 WR
Simi Fehoko: Placed on injured reserve
Nov 12th
Fehoko (wrist) was placed on injured reserve Wednesday, Darren Urban of the Cardinals' official site reports.
#2 WR
Michael Wilson: Poised for WR1 role in short term
Nov 12th
Wilson will take on the No. 1 WR role in the Cardinals offense for at least Sunday's game against the 49ers following Marvin Harrison's appendectomy Monday, Darren Urban of the team's official site reports.
#6 WR
Zay Jones: Officially shifts to IR
Nov 12th
The Cardinals placed Jones (Achilles) on injured reserve Wednesday.
#1 WR
Marvin Harrison: Out for Week 11 due to appendicitis
Nov 12th
Cardinals coach Jonathan Gannon said Wednesday that Harrison will miss Sunday's game against the 49ers after undergoing surgery to address appendicitis, Theo Mackie of The Arizona Republic reports.
#1 LDE
Josh Sweat: Takes down QB in Week 10 loss
Nov 11th
Sweat recorded one tackle (which was a full sack), one forced fumble and one recovered fumble in Sunday's loss to Seattle.
#1 FS
Budda Baker: Records five stops in Week 10 loss
Nov 11th
Baker finished Sunday's loss to the Seahawks with five tackles (two solo).
#1 WLB
Akeem Davis-Gaither: Notches six stops in Week 10
Nov 11th
Davis-Gaither tallied six tackles (two solo) in Sunday's loss to Seattle.
#2 RCB
Denzel Burke: Picks off Darnold in Week 10 loss
Nov 10th
Burke recorded five tackles (four solo) and an interception during the Cardinals' 44-22 loss to the Seahawks on Sunday.
#2 RB
Emari Demercado: Goes for over 100 total yards
Nov 9th
Demercado took four carries for 64 yards while catching three of four targets for 40 yards in Sunday's 44-22 loss to Seattle.
#1 QB
Jacoby Brissett: Mixed results in blowout loss
Nov 9th
Brissett completed 22 of 44 pass attempts for 258 yards and two touchdowns while gaining 31 yards on four carries and losing two fumbles in Sunday's 44-22 loss to Seattle.
#1 K
Chad Ryland: No FGAs in loss
Nov 9th
Ryland did not attempt a field goal and made both of his PATs in Sunday's 44-22 loss to the Seahawks.
#1 TE
Trey McBride: Goes off against SEA
Nov 9th
McBride finished with nine receptions on 13 targets for 127 yards and a touchdown in Sunday's 44-22 loss to the Seahawks.
#1 RDE
Darius Robinson: Suffers groin injury
Nov 9th
Robinson exited Sunday's game against the Seahawks with a groin injury and will not return, Darren Urban of the Cardinals' official site reports.
#2 FS
Kitan Crawford: Green light to play Week 10
Nov 9th
Crawford (ankle) is active for Sunday's game against Seattle.
#3 QB
Kyler Murray: Future in Arizona in limbo
Nov 9th
Murray, who was placed on injured reserve Wednesday due to a mid-foot sprain, is not expected to start again if he returns this season, "absent injury to Jacoby Brissett," Ian Rapoport of NFL Network reports.
#3 RB
Michael Carter: Joins active roster
Nov 8th
The Cardinals signed Carter from the practice squad to the active roster Saturday, Darren Urban of the team's official site reports.
#3 TE
Josiah Deguara: Back with Cards
Nov 5th
Arizona signed Deguara on Wednesday.
#4 RB
Trey Benson: Not practicing Wednesday
Nov 5th
Cardinals coach Jonathan Gannon said Wednesday that Benson (knee) is "doing well" but isn't ready to practice, Theo Mackie of The Arizona Republic reports.
#2 TE
Elijah Higgins: Records three receptions Monday
Nov 4th
Higgins recorded three catches (on three targets) for 30 yards during Monday's 27-17 win in Dallas.
#2 MLB
Cody Simon: Ready to face Cowboys
Nov 3rd
Simon (illness) is active for Monday's game against the Cowboys, Darren Urban of the Cardinals' official site reports.
#1 SCB
Garrett Williams: Activated from IR, playing Monday
Nov 3rd
The Cardinals activated Williams (knee) from injured reserve, and he is active for Monday's game against the Cowboys, Darren Urban of the Cardinals' official site reports.