Roma scored a very important away goal in the first leg, but a win Tuesday would guarantee their spot in the Champions League quarterfinal.
Tottenham are expected to rotate heavily for Wednesday's Champions League match against APOEL, but it could be time for Serge Aurier's coming out party.
A win Wednesday against Spartak Moscow will clinch the top spot in Group E for Liverpool, and they will be looking for Mohamed Salah to continue his excellent run.
Gonzalo Higuain has scored in nine of his last 10 domestic matches, and he's likely to be involved if Juventus are to take anything out of Wednesday's match at FC Porto.