NCAA Men’s Final Four Betting: 2025 Odds, Picks, & Strategy for Tonight's Game

UPDATE: The Florida Gators have advanced to the championship game after defeating the Auburn Tigers, 79-73.

The Men's NCAA Final Four is set, and 2025 marks a historic moment; all four No. 1 seeds have advanced to the semifinals for only the second time since the tournament expanded in 1985. For bettors, this year's Final Four brings both high-level basketball and tighter betting lines. Whether you're wagering on the spread, futures, or player props, this guide will help you navigate the betting market with smart insights and up-to-date odds.

2025 NCAA Final Four Teams & Odds

Odds via DraftKings Sportsbook

Tonight's Game

Duke Blue Devils vs. Houston Cougars

This matchup pits Duke's high-powered offense, led by Cooper Flagg, against Houston's No. 1-ranked defense. The Cougars are physical, gritty, and disruptive. It really is everything you want in a Final Four sleeper pick.

Betting Strategy

When offense meets elite defense, take the defense. Houston may not light it up on the scoreboard, but they're more than capable of turning this into a slugfest. Look at Houston +5.5 or under 144.5 if you're expecting a grinder.

Pick: Under 144.5 with value on Houston +5.5 in a tight, possession-heavy game.

Afternoon Game

Florida Gators vs. Auburn Tigers 

UPDATE: The Florida Gators have advanced to the championship game after defeating the Auburn Tigers, 79-73.

Two SEC powerhouses clash in what promises to be a high-tempo affair. Florida brings a deep roster with consistent guard play, while Auburn rides the physical dominance of Johni Broome and their disruptive defense.

Betting Strategy

Auburn has excelled at covering spreads in high-scoring games. Florida's tempo and transition attack may feed into this. Look at the first half over or Auburn team total over if you expect a fast start.

Pick: Auburn +2.5, and sprinkle Auburn ML (+120) if you're riding the momentum narrative.

Betting the Futures: Who Cuts Down the Nets?

Odds via DraftKings Sportsbook

Best Value: Auburn offers the best return, but if you believe Houston's defense can outlast Duke and Florida's pace, +275 is great value for a battle-tested team with Final Four experience.

Overall Betting Strategies

Live Betting Opportunities
Look for early nerves. If teams come out cold, you can get a better total number on live overs once the pace normalizes.

First Half vs. Full Game Lines
Teams with slow-starting offenses or dome-effect shooting struggles might lead to value on first-half unders.

Player Props to Watch

• Cooper Flagg (Duke): Points + rebounds
• Johni Broome (Auburn): Double-double or blocks props
• Walter Clayton (Florida): Three-pointers made or assists

Betting Smart

The Final Four is one of the sharpest betting markets in sports. Public narratives dominate, lines tighten, and value becomes harder to find. But with all four No. 1 seeds in play, 2025's games offer more than just history, they offer actionable betting edges.

Whether you're wagering pre-game, live or targeting player props, stay sharp, line shop, and bet with discipline.

Final Four Betting FAQ

Q: Where can I legally bet on the Final Four?
A: DraftKings, FanDuel, Caesars, BetMGM, Fanatics and most major legal sportsbook apps in the U.S. offer full markets and great betting promos.

Q: What's the best bet if I missed pre-tournament futures?
A: Consider Final Four MVP (Most Outstanding Player) props or semifinal game spreads for better-defined value.

Q: How rare is it for all No. 1 seeds to make the Final Four?
A: This is only the second time since 1985. The last time was in 2008. That year, the eventual champion, Kansas, was the most well-rounded team -- similar to what we're seeing with Duke or Florida now.

Q: I need a Final Four bet, what is it?
A: Look for value in the Auburn-Florida game total, and don't sleep on Houston's defense keeping things close. Smart bets, not just big ones, will carry the day. And be sure to check out all these great March Madness betting promos before tip off.

Best Final Four Promos & Bonuses

Promos last verified: Saturday, April 5, 2025.

Final Four 2025 Location & Schedule

Date: Saturday, April 5, 2025 (Championship Game: April 7)

Venue: Alamodome in San Antonio, Texas

Broadcast: CBS / Paramount+

The Alamodome's vast interior often plays a role in shooting variance, especially early in games. That's something to keep in mind when considering first-half unders or team three-point props.

For more Final Four betting news, tools, expert picks and more, sign up to RotoWire now and explore all we have to offer.

This article is part of our Betting Promotions series.