Louisville
25.0 Pts
SMU
27.5 Pts
Saturday November 22, 2025 at 12:00 PM ET
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Moneyline
DraftKings DraftKings
-135
PROBABILITY with vig removed
Lou Cardinals Win (+114)
44.9%
SMU Mustangs Win (-135)
55.1%
LINE MOVEMENT
Spread
DraftKings DraftKings
-2.5
PROBABILITY with vig removed
Lou Win or Lose By < 3 Pts(-105)
48.9%
SMU Win By 3+ Pts(-115)
51.1%
LINE MOVEMENT
Over Under
DraftKings DraftKings
52.5
Points
PROBABILITY with vig removed
Over 53 Total Points(-112)
50.4%
Under 53 Total Points(-108)
49.6%
LINE MOVEMENT
Lou
Cardinals Injury Report
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SMU
Mustangs Injury Report
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Lou
Cardinals News
#1 WR
Chris Bell: Solid output in rough loss
Nov 17th
Bell totaled five receptions (on nine targets) for 79 yards during Friday's 20-19 defeat to Clemson.
#2 WR
Caullin Lacy: Catches all four targets
Nov 17th
Lacy reeled in all four targets for 60 yards during Friday's 20-19 loss to Clemson.
#2 RB
Keyjuan Brown: Another big day
Nov 17th
Brown totaled 15 rushes for 135 yards and gathered in all two targets for 14 yards during Friday's 20-19 loss to Clemson.
#1 QB
Miller Moss: Can't fend off Tigers
Nov 17th
Moss completed 19 of 27 passes for 212 yards during Friday's 20-19 defeat against Clemson. He also had four rushes for negative three yards with one touchdown.
#1 RB
Isaac Brown: Remains out Friday
Nov 12th
Brown (lower leg) did not appear on the teams injury report but will still not play in Friday's game versus Clemson, Matt McGavic of SI.com reports.
#3 RB
Duke Watson: Good to go Saturday
Nov 8th
Watson (undisclosed) is available for Saturday's game against California.
SMU
Mustangs News
#3 WR
Yamir Knight: Goes off against BC
Nov 10th
Knight compiled seven receptions (on nine targets) for 162 yards and one touchdown during Saturday's 45-13 win over Boston College.
#1 WR
Jordan Hudson: Another 100-yard game
Nov 10th
Hudson reeled in 5 of 8 targets for 104 yards and one touchdown during Saturday's 45-13 victory against Boston College.
#2 RB
Derrick McFall: Scores thrice in blowout
Nov 10th
McFall recorded five carries for 64 yards and three touchdowns and gathered in 0 of 2 targets for zero yards during Saturday's 45-13 win against Boston College.
#1 RB
TJ Harden: Erupts for 130 yards
Nov 10th
Harden recorded 16 carries for 130 yards and gathered in their only target for negative three yards during Saturday's 45-13 win against Boston College.
#1 QB
Kevin Jennings: Gashes BC in win
Nov 10th
Jennings was 16-for-32 passing for 326 yards, three touchdowns and one interception during Saturday's 45-13 win versus Boston College.
#5 WR
Link Rhodes: DNP in Week 11
Nov 9th
Rhodes (undisclosed) didn't play in Saturday's 45-13 win over Boston College.
#3 RB
Chris Johnson: Limited in win
Nov 9th
Johnson (undisclosed) logged six kick return yards and didn't receive a carry during Saturday's 45-13 victory versus Boston College.
#1 TE
RJ Maryland: Ready to roll
Nov 8th
Maryland will be active for Saturday's game against Boston College.
#2 WR
Romello Brinson: Suiting up Saturday
Nov 7th
Brinson (undisclosed) is not on the injury report and will be available to face Boston College on Saturday.