NFL Week 1 odds came out on all the best sportsbooks following the release of the 2024-25 NFL schedule in May. These first set of NFL Week 1 odds that are released are referred to as the "opening" lines.
NFL Week 1 kicks off on Thursday, September 5, 2024, with the first game starting at 8:20 p.m. ET on Thursday Night Football on NBC. The opening matchup features a thrilling rematch of the 2023 AFC Championship game between the Baltimore Ravens and the Kansas City Chiefs.