August 16, 2025
ANALYSISMcCaffrey has been a full-go at training camp, but the 49ers will opt to rest him for a second consecutive preseason game. The veteran running back's final opportunity to handle exhibition reps will come Saturday, Aug. 23 against the Chargers, but it remains to be seen whether San Francisco will consider allowing him to suit up, or take a conservative to the All-Pro's health until Week 1. With
Isaac Guerendo (shoulder) and
Jordan James (finger) both nursing injuries, a combination of
Patrick Taylor,
Ke'Shawn Vaughn,
Corey Kiner and
Jeff Wilson will handle backfield reps on Saturday.