Isaac Guerendo News: Falls out of favor in 2025

Guerendo was only utilized on special teams this season, finishing with 100 kick return yards across 14 active games.

Guerendo entered his sophomore campaign with an opportunity to serve as Christian McCaffrey's primary backup, but he failed to seize the role in training camp and the team opted to trade for veteran RB Brian Robinson (92-400-2) to fill that role instead. The 25-year-old Guerendo averaged 5.0 yards per carry in his rookie season, so it was a bit surprising to see San Francisco's coaching staff give him zero carries in 2025. The Louisville product was healthy for the majority of the schedule and appeared in 14 games as a member of the special teams unit. Guerendo still has two years left on his rookie contract, but it doesn't appear that the 49ers view the running back as part of the team's long-term vision on offense.