2025 Rush/Rec Stats
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0
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0
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0
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Rest-of-Season Projections
2025 Fantasy Outlook
Few running backs in NFL history come close to the raw athletic ability of Guerendo, who at 6 feet, 220 pounds has blazing speed (4.33 40) and elite explosiveness (41.5-inch vertical, 129-inch broad jump). It's such a shame, then, that Guerendo may be one of the most fragile RB prospects in recent memory. He had horrendous injury luck for all but one of the past six years, at one point in college suffering hamstring tears two years in a row before suffering a Lisfranc injury the third year. In his 2024 rookie year, Guerendo missed time at various points with hamstring, groin and foot injuries, and in the season finale against Arizona he suffered an MCL sprain and ankle sprain in the same leg. As if to make all of this more tormenting, Guerendo has real skill in addition to his ridiculous athleticism - he runs with power and is likely an above-average receiver - but it just isn't clear he can ever stay healthy to realize his upside. For now, Guerendo will compete with August trade acquisition Brian Robinson for the second spot on San Francisco's RB depth chart, behind workhorse Christian McCaffrey. Read Past Outlooks
RANKS
Returns one kickoff Thursday
Guerendo ran back one kickoff for 18 yards while receiving no carries or targets in Thursday's 26-23 overtime win over the Rams.
ANALYSIS
Christian McCaffrey continued to operate as San Francisco's bell cow (88 percent) while Brian Robinson (14 percent) remained the clear No. 2, which leaves Guerendo parked in the garage when the team is on offense. The 2024 fourth-round selection is stuck on special teams for the foreseeable future, needing an injury ahead of him on the depth chart to open up playing time. Guerendo generates no fantasy value in his current role when the 49ers visit the Buccaneers in Week 6.
Christian McCaffrey continued to operate as San Francisco's bell cow (88 percent) while Brian Robinson (14 percent) remained the clear No. 2, which leaves Guerendo parked in the garage when the team is on offense. The 2024 fourth-round selection is stuck on special teams for the foreseeable future, needing an injury ahead of him on the depth chart to open up playing time. Guerendo generates no fantasy value in his current role when the 49ers visit the Buccaneers in Week 6.
NFL Stats
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Fantasy/Red Zone Stats
See red zone opportunities inside the 20, 10 and 5-yard lines along with the percentage of time they converted the opportunity into a touchdown.
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2025 NFL Game Log
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2025 NFL Game Log
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Snap Distribution / Depth Chart
Snap Counts
Snap %
Receiving Alignment Breakdown
See where Isaac Guerendo lined up on the field and how he performed at each spot.
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This Week's Opposing Pass Defense
How does the Rams pass defense compare to other NFL teams this season?
The bars represents the team's percentile rank (based on QB Rating Against). The longer the bar, the better their pass defense is. The team and position group ratings only include players that are currently on the roster and not on injured reserve. The list of players in the table only includes defenders with at least 3 attempts against them.
@ Rams
Thursday, Oct 2nd at 8:15PM
Overall QB Rating Against
83.6
Cornerbacks
111.2
Safeties
62.6
Linebackers
88.4
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2025 Isaac Guerendo Split Stats
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Measurables Review
View College Player Page
How do Isaac Guerendo's measurables compare to other running backs?
This section compares his draft workout metrics with players at the same position. The bar represents the player's percentile rank. For example, if the bar is halfway across, then the player falls into the 50th percentile for that metric and it would be considered average.
Height
6' 0"Weight
221 lbs40-Yard Dash
4.33 secShuttle Time
4.15 secCone Drill
6.94 secVertical Jump
41.5 inBroad Jump
129 inHand Length
9.25 inArm Length
30.75 in2024 Fantasy Outlook
A 4.33 40-yard time and a strong overall performance at the Combine launched Guerendo up draft boards, and the 49ers traded up in the fourth round to make sure they got the 221-pound speedster. Kyle Shanahan's offense is arguably the best in the league for a running back, especially one with game-breaking speed, though Guerendo figures to begin his career behind three-down workhorse Christian McCaffrey and the brittle Elijah Mitchell. Guerendo was never a lead back during his time at Wisconsin and Louisville, but he averaged 6.1 yards on 132 carries for the Cardinals last season and now becomes one of the fastest running backs in the NFL.
More Fantasy News
Logs 14 snaps on special teams
Guerendo logged 14 snaps on special teams and was not used on offense in Sunday's 26-21 loss to the Jaguars.
ANALYSIS
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Stuck on special teams
Guerendo did not receive a carry while gaining 19 yards on a kickoff return in Sunday's 16-15 win over the Cardinals.
ANALYSIS
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No carries in Week 2 win
Guerendo returned two kickoffs for 47 yards and was not used on offense in Sunday's 26-21 win over the Saints.
ANALYSIS
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Limited to special teams
Guerendo played 15 snaps on special teams and did not receive a carry in Sunday's 17-13 win over the Seahawks.
ANALYSIS
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Full practice Wednesday
Guerendo (shoulder) practiced fully Wednesday, Cam Inman of The San Jose Mercury News reports.
ANALYSIS
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Latest Fantasy Rumors
Significant competition added
Guerendo is now joined on the 49ers' running back depth chart by Brian Robinson, who was traded from the Commanders to San Francisco on Friday, as reported by John Keim and Adam Schefter of ESPN.
ANALYSIS
Guerendo showed plenty or promise with his opportunities during his rookie campaign, averaging 5.0 yards per carry on 84 rush attempts while adding four rushing touchdowns. However, the second-year back has a fairly lengthy injury history dating back to college and just overcame a shoulder injury, which may have played a role in the team's decision to acquire another starting-quality running back in Robinson. Guerendo may still have a leg up on the No. 2 job to begin the season due to Robinson's unfamiliarity with the playbook, but any absences on the part of the former could lead to some longer-term reordering of the depth chart behind McCaffrey.
Guerendo showed plenty or promise with his opportunities during his rookie campaign, averaging 5.0 yards per carry on 84 rush attempts while adding four rushing touchdowns. However, the second-year back has a fairly lengthy injury history dating back to college and just overcame a shoulder injury, which may have played a role in the team's decision to acquire another starting-quality running back in Robinson. Guerendo may still have a leg up on the No. 2 job to begin the season due to Robinson's unfamiliarity with the playbook, but any absences on the part of the former could lead to some longer-term reordering of the depth chart behind McCaffrey.