The biggest mismatch of the weekend is clear, with Saquon Barkley already having scored four TDs against the Commanders this season. RW's Jerry Donabedian has the full breakdown.
Amon-Ra St. Brown against Noah Igbinoghene could prove to be a problem for Washington's defense.
The Texans insist on playing safeties in the slot, which might be a way of asking for trouble from Ladd McConkey.
Justin Jefferson looks truly unstoppable in a game where the Vikings need points and the Lions probably can't cover.
Terry McLaurin should stay hot against a Titans defense starting its third- and fourth-string corners on the boundary.
Deebo Samuel could go nuts as the desperate 49ers take aim at a weak Tampa Bay corner rotation.
Justin Jefferson will almost certainly have a big game Sunday, and the Colts pass defense is weak enough for Jordan Addison to get rolling in the same game.
Philadelphia's secondary has been excellent with Cooper DeJean in the slot, and their success should continue Week 9 against a banged-up Jacksonville offense.
With Tua Tagovailoa back in the lineup Jaylen Waddle should get rolling against Arizona, and the same is true of Tyreek Hill if he plays through his foot injury.
Drake London's breakout should continue against a Seattle secondary that might be without its two starting boundary corners.
The showdown between Detroit and Dallas could set up a punch-for-punch heavyweight contest where CeeDee Lamb and Amon-Ra St. Brown both go off.
Michael Pittman got back on track in Week 4 and should keep it rolling in Week 5, as neither the Jags nor Colts have viable coverage personnel.
Erik Siegrist previews the Monday night games as Nick Chubb and the Browns face the division-rival Steelers on the road in the nightcap.
The Seahawks-Cardinals matchup is full of fantasy goodness, and it isn't just a matter of the defenses stinking it up (ok, it's a lot of that).