
Brandon Aiyuk's acceleration and ball-tracking skills could spell trouble for Kansas City's middling safeties, but first the Niners need to keep DL Chris Jones off of Brock Purdy.

Tyreek Hill and De'Von Achane both are questionable, and their numbers might disappoint even if they play given Miami's slew of injury concerns along the offensive line.

Perhaps the only question mark in a 49ers offense led by RB Christian McCaffrey, WRs Deebo Samuel and Brandon Aiyuk and TE George Kittle is quarterback. Brock Purdy will attempt to repeat his success from 2022.