Injuries to Christian McCaffrey and Jordan Mason leave Isaac Guerendo as San Francisco's starting RB for the final month of the season.
Justin Jefferson will almost certainly have a big game Sunday, and the Colts pass defense is weak enough for Jordan Addison to get rolling in the same game.
RW's Jerry Donabedian expects Josh Downs to pile up targets with the Colts turning back to Joe Flacco against a zone-heavy, blitz-heavy Minnesota defense.
Nico Collins plans to play this weekend after logging limited practices Wednesday through Friday.