Lyon will look to avenge their previous loss to Rennes, and they'll need Nabil Fekir to step up if they want to have a chance.
A win Thursday over Rapid Wien would see Inter Milan through to the round of 16, and the bookmakers are expecting Lautaro Martinez to make an impact.
Arsenal are the biggest favorite on Thursday's early eight-game slate, and no player has higher anytime goal scorer odds than Pierre-Emerick Aubameyang.
Marseille are expected to handle Guingamp on Friday, with Florian Thauvin coming in with the best anytime goal scoring odds.