Borussia Dortmund host Bayern Munich in Saturday's Der Klassiker, as Ethan Sexton looks to bet that contest and a few others for his top picks from Bundesliga, La Liga and Serie A.
Sevilla are favored away to Levante on Friday, which means fantasy players will likely have Pablo Sarabia in their sights.
Many fantasy managers will be handing over the captain's armband to Romelu Lukaku in his Man United league debut, but Adam Zdroik makes the case for a striker from the other side of Manchester.
Chelsea are the biggest favorites on Saturday's slate, with fantasy managers likely to strongly consider Willian.
While he doesn't have the goal upside of some of his teammates, Real Madrid's Toni Kroos still offers plenty for fantasy managers.