Club America are big favorites at home to Atlas on Saturday, while the Chivas-Cruz Azul match expected to be very close.
Toronto FC are still looking for their first goal of the 2018 MLS season, and they'll look toward Sebastian Giovinco to break through Friday against Real Salt Lake.
Saturday's five-game slate is packed with solid fantasy producers, and most of the games are expected to be close, with Monterrey the only solid favorite.
Tigres are the biggest favorites on Saturday's five-game slate, but that doesn't mean fantasy players won't be able to find points elsewhere.
Monterrey are the biggest favorites on Wednesday's six-game slate, but they don't have the highest implied goal total, which will force fantasy players to diversify their lineups.
Landon Donovan is unlikely to play Saturday, but there are still plenty of fantasy points to be had on the four-game Liga MX slate.