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Seahawks vs 49ers Odds, Lines, Spreads & Totals 2025

49ers
23.5 Pts
Seahawks
21.0 Pts
Sunday September 7, 2025 at 4:05 PM ET
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SF
49ers Injury Report
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SEA
Seahawks Injury Report
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SF
49ers Lineup
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SEA
Seahawks Lineup
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SF
49ers News
#7 RB
Corey Kiner: Reverts to IR with San Francisco
Aug 21st
Kiner (ankle) reverted to injured reserve with the 49ers on Thursday, Nick Wagoner of ESPN.com reports.
#3 SCB
Tre Brown: Placed on IR
Aug 21st
Brown (heel) was placed on injured reserve Thursday.
#5 QB
Tanner Mordecai: Back with San Fran
Aug 21st
Mordecai signed with the 49ers on Thursday.
#3 RDE
Robert Beal: Back from groin injury
Aug 21st
Beal (groin) returned to practice Thursday, Nick Wagoner of ESPN.com reports.
#6 WR
Skyy Moore: Likely to play Saturday
Aug 21st
San Francisco head coach Kyle Shanahan said Thursday that Moore is expected to suit up for Saturday's preseason finale against the Chargers, David Lombardi of SFStandard.com reports.
#8 WR
Russell Gage: Managing MCL sprain
Aug 21st
Gage (knee) is expected to miss seven to 10 days due to a sprained MCL, Adam Schefter of ESPN reports.
#14 WR
Malik Knowles: Signs with 49ers
Aug 20th
The 49ers signed Knowles on Wednesday.
#4 WR
Demarcus Robinson: Suspended three games
Aug 20th
San Francisco head coach Kyle Shanahan said Wednesday that Robinson has been suspended the first three games of the regular season for violating the NFL's substance abuse policy, Adam Schefter of ESPN reports.
#5 WR
Jacob Cowing: Missing practice time again
Aug 20th
Cowing isn't practicing Wednesday after suffering a lower-body injury Tuesday, Matt Maiocco of NBC Sports Bay Area reports.
#6 RB
Patrick Taylor: Will get surgery on shoulder
Aug 19th
Taylor will undergo season-ending surgery to repair a fracture in his shoulder, Nick Wagoner of ESPN.com reports.
#1 DT2
Jordan Elliott: Returns from back issue
Aug 19th
Elliott (back) participated during Tuesday's training camp practice, Nick Wagoner of ESPN.com reports.
#2 RDE
Sam Okuayinonu: Returns to practice
Aug 19th
Okuayinonu (groin) participated during Tuesday's training camp practice, Nick Wagoner of ESPN.com reports.
#1 RDE
Nick Bosa: Practicing in limited capacity
Aug 19th
Bosa (neck) was limited to individual drills during Tuesday's training camp practice, Nick Wagoner of ESPN.com reports.
#2 FS
Jason Pinnock: Still working through heel issue
Aug 19th
Pinnock (heel) was limited to individual drills during Tuesday's training camp practice, Nick Wagoner of ESPN.com reports.
#1 LCB
Renardo Green: Back practicing
Aug 19th
Green (hamstring) participated during Tuesday's training camp practice, Nick Wagoner of ESPN.com reports.
#1 SCB
Upton Stout: Expected back by Week 1
Aug 19th
Coach Kyle Shanahan said Tuesday that the 49ers aren't worried about Stout's (calf) availability for Week 1 against the Seahawks on Sept. 7, David Lombardi of SFStandard.com reports.
#2 RB
Isaac Guerendo: Returns to practice
Aug 19th
Guerendo (shoulder) participated in Tuesday's training camp practice, Nick Wagoner of ESPN.com reports.
#2 QB
Mac Jones: Out for preseason finale
Aug 19th
Jones will miss Saturday's preseason finale against the Chargers due to a knee sprain, Adam Schefter of ESPN reports.
#3 SLB
Chazz Surratt: Tallies six tackles Sunday
Aug 17th
Surratt (undisclosed) tallied six tackles (six solo) during San Francisco's preseason win over the Raiders on Saturday.
#3 FS
Marques Sigle: Logs three tackles in preseason win
Aug 17th
Sigle (knee) logged three tackles (three solo) in San Francisco's preseason win over the Raiders on Saturday.
#1 FB
Kyle Juszczyk: Plays six snaps in preseason debut
Aug 17th
Juszczyk (Achilles) played six snaps on offense without otherwise showing up on the box score during the 49ers' 22-19 preseason win over the Raiders on Saturday.
#1 SS
Ji'Ayir Brown: Makes preseason debut vs. Raiders
Aug 17th
Brown (ankle) logged four tackles (three solo) during the 49ers' 22-19 preseason win over the Raiders on Saturday.
#2 MLB
Tatum Bethune: Past ankle injury
Aug 17th
Bethune (ankle) logged two tackles (one solo) during Saturday's 22-19 preseason win over the Raiders.
#3 DT2
Evan Anderson: Past knee issue
Aug 17th
Anderson (knee) played 27 snaps (25 on offense, two on special teams) but did not otherwise appear in the box score in the 49ers' 22-19 preseason win over the Raiders on Saturday.
#1 K
Jake Moody: Makes five fields goals Saturday
Aug 16th
Moody went 5-for-6 on field-goal attempts and 1-for-1 in extra-point tries during a 22-19 preseason win against the Raiders on Saturday.
#3 WR
Ricky Pearsall: Connects with Purdy for 42 yards
Aug 16th
Pearsall caught three of four targets for 42 yards in a 22-19 exhibition win against Las Vegas on Saturday.
#1 QB
Brock Purdy: Looks good in preseason debut
Aug 16th
Purdy completed five of seven pass attempts for 66 yards with no touchdowns or interceptions in a 22-19 exhibition win over the Raiders on Saturday.
#1 RG
Dominick Puni: Expected to miss multiple weeks
Aug 16th
Puni suffered a possible PCL injury in Saturday's preseason game against the Raiders and is expected to miss a few weeks, Eric Branch of the San Francisco Chronicle reports.
#1 TE
George Kittle: Set for preseason action
Aug 16th
Kittle will suit up alongside Brock Purdy and the majority of the 49ers' starters during Saturday's preseason game against the Raiders, Jennifer Lee Chan of NBC Sports Bay Area reports.
#1 RB
Christian McCaffrey: Won't take field Saturday
Aug 16th
McCaffrey will not join Brock Purdy and the majority of San Francisco's starters in suiting up for Saturday's preseason game against the Raiders, David Lombardi of SFStandard.com reports.
#2 LDT
CJ West: Won't play Saturday
Aug 16th
West (knee) has been ruled out for Saturday's preseason game against the Raiders, Eric Branch of the San Francisco Chronicle reports.
#1 LDE
Mykel Williams: Won't play against Raiders
Aug 16th
Williams (knee) has been ruled out for Saturday's preseason game against Las Vegas, Eric Branch of the San Francisco Chronicle reports.
#2 SS
Richie Grant: Won't play vs. Las Vegas
Aug 16th
Grant (knee) will not play in Saturday's preseason game against the Raiders, Cam Inman of The San Jose Mercury News reports.
#1 LG
Ben Bartch: Out for second preseason game
Aug 14th
Bartch (elbow) won't be available for Saturday's preseason game against Las Vegas, Nick Wagoner of ESPN.com reports.
#4 LT
Andre Dillard: Lands on injured reserve
Aug 14th
Dillard (ankle) was placed on injured reserve Thursday.
#12 WR
Malik Turner: Back in Bay Area
Aug 13th
The 49ers signed Turner to a contract Wednesday.
#7 WR
Jordan Watkins: Has high-ankle sprain
Aug 11th
San Francisco head coach Kyle Shanahan said Monday that Watkins is nursing a high-ankle sprain and will be out roughly one month, Vic Tafur of The Athletic reports.
#1 WR
Brandon Aiyuk: Could be ready for Week 6
Aug 11th
San Francisco head coach Kyle Shanahan said Monday that Week 6 could be a realistic target for Aiyuk (ACL) to take the field, Vic Tafur of The Athletic reports.
#3 LCB
Fabian Moreau: Misses preseason opener
Aug 10th
Moreau (undisclosed) did not play in Saturday's 30-9 preseason loss to Denver, Matt Barrows of The Athletic reports.
#5 RB
Jeff Wilson: Reuniting with Niners
Aug 10th
The 49ers signed Wilson to a contract Sunday, Adam Schefter of ESPN reports.
#4 RB
Ke'Shawn Vaughn: Back with Niners
Aug 9th
The 49ers signed Vaughn to a contract Saturday.
SEA
Seahawks News
#1 LT
Charles Cross: Ramping up participation
Aug 21st
Cross (finger) participated in 11-on-11 team drills at practice Thursday, John Boyle of the Seahawks' official website reports.
#2 SLB
Uchenna Nwosu: Participates in workout
Aug 21st
Nwosu went through a workout in full pads Thursday, John Boyle of the Seahawks' official website reports.
#1 LILB
Tyrice Knight: Should be ready for season opener
Aug 21st
Knight (knee) is expected to be ready by Week 1 against the 49ers, head coach Mike Macdonald said Thursday, Brady Henderson of ESPN.com reports.
#3 QB
Jalen Milroe: Will play entire preseason finale
Aug 21st
Seahawks coach Mike Macdonald said Thursday that Milroe will start and play the entirety of Saturday's preseason finale on the road against Green Bay, Michael-Shawn Dugar of The Athleticreports.
#3 LILB
Josh Ross: Returns to practice
Aug 19th
Ross (hand) was back in action at practice Tuesday, Curtis Crabtree of Fox 13 Seattle reports.
#1 C
Olu Oluwatimi: Back in action
Aug 19th
Oluwatimi (back) returned to practice Tuesday, Curtis Crabtree of Fox 13 Seattle reports.
#3 WR
Tory Horton: Doesn't practice Tuesday
Aug 19th
Horton (ankle) did not participate in Tuesday's training camp practice, Curtis Crabtree of Fox 13 Seattle reports.
#4 WR
Marquez Valdes-Scantling: No catches during preseason so far
Aug 18th
Valdes-Scantling wasn't targeted in Friday's 33-16 preseason win over the Chiefs.
#5 WR
Jake Bobo: Scores twice in preseason win
Aug 17th
Bobo caught two passes for 24 yards and two touchdowns in Friday's 33-16 preseason win over the Chiefs.
#3 RB
George Holani: Breaks off long run
Aug 17th
Holani rushed five times for 49 yards in Friday's 33-16 preseason win over the Chiefs. He also returned three kicks for 73 yards.
#6 WR
Dareke Young: Leading receiver in preseason win
Aug 17th
Young caught three passes (three targets) for 52 yards in Friday's 33-16 preseason win over the Chiefs. He also returned a kick for 29 yards.
#4 RB
Damien Martinez: Scores in preseason win
Aug 17th
Martinez rushed 11 times for 50 yards and a score in Friday's 33-16 preseason win over the Chiefs. He also caught two passes for 14 yards.
#2 TE
Elijah Arroyo: Logs two receptions Friday
Aug 15th
Arroyo brought in both of his targets for 19 yards in Friday's 33-16 preseason win over Kansas City.
#1 TE
AJ Barner: Logs one catch with starters
Aug 15th
Barner pulled in his only target for five yards in Friday's 33-16 preseason win over the Chiefs.
#2 WR
Cooper Kupp: No targets in preseason debut
Aug 15th
Kupp started Friday's preseason tilt against the Chiefs, but he did not receive a target during his brief appearance.
#2 RB
Zach Charbonnet: Sees first preseason work
Aug 15th
Charbonnet took five carries for 45 yards and a touchdown in Friday's 33-16 preseason win over Kansas City.
#1 QB
Sam Darnold: Plays one series Friday
Aug 15th
Darnold completed all four of his pass attempts for 34 yards in Friday's 33-16 preseason win over the Chiefs.
#1 WR
Jaxon Smith-Njigba: Light work in preseason debut
Aug 15th
Smith-Njigba brought in his only target for seven yards in Friday's 33-16 preseason win over Kansas City.
#3 FB
Wesley Steiner: Joins Seattle
Aug 14th
Steiner signed with the Seahawks on Thursday.
#1 RB
Kenneth Walker: Practicing part-time
Aug 12th
Walker has been alternating days on and off the practice field since returning from a minor foot injury last week, Gregg Bell of The News Tribune reports.
#2 RG
Christian Haynes: Over pectoral issue
Aug 8th
Haynes (pectoral) played in Thursday night's preseason opener against the Bengals.
#3 LCB
Nehemiah Pritchett: Registers INT in preseason
Aug 8th
Pritchett recorded four solo tackles and two pass breakups, including an interception, in Thursday's 23-23 preseason tie versus the Raiders.
#6 RB
Anthony Tyus: Generates 23 yards
Aug 8th
Tyus rushed six times for 23 yards in Thursday's 23-23 preseason tie versus the Raiders.
#3 FS
Jerrick Reed: Makes five stops in tie
Aug 8th
Reed (quadriceps) made five tackles (three solo) in Thursday's 23-23 tie versus the Raiders.
#1 P
Michael Dickson: Booming punts Thursday
Aug 8th
Dickson punted four times for 222 yards (55.5 average) in Thursday's 23-23 tie versus the Raiders.
#1 K
Jason Myers: Misses extra point Thursday
Aug 8th
Myers connected on a 48-yard field goal and made two of three extra-point tries in Thursday's 23-23 tie versus the Raiders.
#7 WR
Ricky White: Makes one catch Thursday
Aug 8th
White (undisclosed) caught his lone target for 14 yards in Thursday's 23-23 preseason tie versus the Raiders.
#8 WR
Cody White: No catches in preseason opener
Aug 8th
White didn't catch either of his two targets in Thursday's 23-23 tie against the Raiders.