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Titans vs Colts Odds, Lines, Spreads & Totals 2025

Colts
23.5 Pts
Titans
20.0 Pts
Sunday September 21, 2025 at 1:00 PM ET
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Titans Injury Report
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Colts Lineup
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Titans Lineup
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Colts News
#2 RB
DJ Giddens: Small role in Week 2
Sep 15th
Giddens did not have a carry and did not catch his lone target in Sunday's win over the Broncos. He played just five snaps on offense.
#4 WR
Adonai Mitchell: Two receptions in win
Sep 15th
Mitchell had two receptions for 20 yards on four targets in Sunday's win over the Broncos.
#2 WR
Alec Pierce: Has 68 yards receiving in win
Sep 15th
Pierce had four receptions for 68 yards on five targets in Sunday's win over Denver.
#1 MLB
Zaire Franklin: Underwhelms in Week 2
Sep 15th
Franklin recorded five total tackles (three solo) and one pass defended in Sunday's 29-28 win over the Broncos.
#3 WR
Josh Downs: Gets more involved in Week 2
Sep 14th
Downs recorded six receptions on eight targets for 51 yards in Sunday's 29-28 win over the Broncos.
#1 QB
Daniel Jones: Strong showing against Denver
Sep 14th
Jones completed 23 of 34 passes for 316 yards, one touchdown and no interceptions in Sunday's 29-28 win over the Broncos. He added six rush attempts for two yards and a touchdown.
#1 TE
Tyler Warren: Another impressive showing
Sep 14th
Warren recorded four receptions on seven targets for 79 yards in Sunday's 29-28 win over the Broncos. He also logged one carry for zero yards.
#1 WR
Michael Pittman: Held to 40 yards
Sep 14th
Pittman recorded four receptions on five targets for 68 yards in Sunday's 29-28 win over the Broncos.
#1 K
Spencer Shrader: Kicks Indy to victory
Sep 14th
Shrader drilled all five of his field-goal attempts and both of his extra-point tries in the Colts' 29-28 win over the Broncos on Sunday.
#1 RB
Jonathan Taylor: Tops 200 yards from scrimmage
Sep 14th
Taylor recorded 25 carries for 165 yards in Sunday's 29-28 win over the Broncos. He added two receptions on two targets for 50 yards and a touchdown.
#4 TE
Will Mallory: Healthy scratch Week 2
Sep 14th
Mallory (coach's decision) is inactive for Sunday's game against the Broncos.
#3 QB
Riley Leonard: Emergency QB3 vs. Denver
Sep 14th
Leonard (coach's decision) is inactive against the Broncos on Sunday but will serve as the Colts' emergency third-string quarterback.
#1 RDE
Laiatu Latu: Won't play against Denver
Sep 14th
Latu (hamstring) is inactive for Sunday's game against the Broncos.
#3 RB
Tyler Goodson: Remains inactive Sunday
Sep 14th
Goodson (elbow) is inactive for Sunday's Week 2 game against the Broncos.
#3 RCB
Jaylon Jones: Lands on IR
Sep 13th
Jones (hamstring) was placed on injured reserve Saturday.
#1 LCB
Charvarius Ward: Ruled out against Broncos
Sep 12th
Ward (concussion) won't play Sunday against the Broncos, James Boyd of The Athletic reports.
#2 MLB
Chad Muma: Healthy scratch for opener
Sep 8th
Muma was inactive for Sunday's win over Miami.
#2 RCB
Johnathan Edwards: Healthy scratch for opener
Sep 8th
Edwards was inactive for Sunday's win over Miami.
#1 RCB
Xavien Howard: Recovers fumble in Colts debut
Sep 8th
Howard started at cornerback opposite Charvarius Ward and recovered a fumble but did not have a tackle in Sunday's win over Miami.
#3 LDE
JT Tuimoloau: Healthy scratch for opener
Sep 8th
Tuimoloau was a healthy inactive for Sunday's win over Miami.
#2 SS
Daniel Scott: Limited role in NFL debut
Sep 8th
Scott played nine snaps on defense and nine snaps on special teams but did not record a tackle in Sunday's win over Miami.
#2 DT2
Neville Gallimore: Reserve role in season opener
Sep 8th
Gallimore had a pass defensed by tipping a pass attempt but no tackles in Sunday's win over Miami. He played on 13 of the defense's 47 snaps.
#3 DT2
Adetomiwa Adebawore: Reserve role in season opener
Sep 8th
Adebawore had one assisted tackle in Sunday's win over Miami. He played on 13 of the defense's 47 snaps.
#2 LDE
Tyquan Lewis: Just one tackle in season opener
Sep 8th
Lewis had one assisted tackle and one QB hurry in Sunday's win over Miami. He played on 23 of the defense's 47 snaps.
#1 WLB
Cameron McGrone: Reserve role in season opener
Sep 8th
McGrone had one total tackle in Sunday's win over Miami.
#2 SLB
Segun Olubi: Limited to special teams
Sep 8th
Olubi had one total tackle in Sunday's win over Miami.
#1 LDE
Kwity Paye: Just one tackle in season opener
Sep 8th
Paye had a tackle for a loss for his only total tackle in Sunday's win over Miami.
#2 LDT
Eric Johnson: Limited role in season opener
Sep 8th
Johnson had one total tackle in Sunday's win over Miami. He played on seven of the defense's 47 snaps.
#1 LDT
Grover Stewart: Two tackles in season opener
Sep 8th
Stewart started at defensive tackle and had two total tackles and a QB hit in Sunday's win over Miami.
#1 DT2
DeForest Buckner: Three tackles in opener
Sep 8th
Buckner had three total tackles, a QB hit and a QB hurry in Sunday's win over Miami.
#2 LCB
Mekhi Blackmon: Three tackles in Colts debut
Sep 8th
Blackmon had three total tackles in Sunday's win over Miami.
#2 FS
Rodney Thomas: Three tackles in opener
Sep 8th
Thomas had three total tackles, including a tackle for a loss, in Sunday's win over Miami.
#1 SLB
Joe Bachie: Six tackles in opener
Sep 8th
Bachie started at linebacker opposite Zaire Franklin and had six total tackles in Sunday's win over Miami.
#2 RDE
Samson Ebukam: Records sack in season opener
Sep 8th
Ebukam had 1.0 sack and three total QB hits in Sunday's win over Miami.
#1 SCB
Kenny Moore: Gets sack in season opener
Sep 8th
Moore had four total tackles, including 1.0 sacks, in Sunday's win over Miami.
#1 FS
Camryn Bynum: Nabs interception in Colts debut
Sep 8th
Bynum had three total tackles and an interception in Sunday's win over Miami.
#1 SS
Nick Cross: Six tackles and sack in opener
Sep 8th
Cross had six total tackles, including 1.0 sacks, in Sunday's win over Miami.
#6 WR
Anthony Gould: Used as punt returner
Sep 8th
Gould was used as Indianapolis' punt returner and played two snaps on special teams, but he didn't see any action on offense in Sunday's win over Miami.
#5 WR
Ashton Dulin: Minimal role on offense in opener
Sep 8th
Dulin had one carry on a reverse for 15 yards in Sunday's win over Miami. He played on 10 of the offense's 73 snaps but did not have a target in the passing game. He also had one kick return for 27 yards.
#3 TE
Drew Ogletree: Gets time in blocking role
Sep 8th
Ogletree did not have a reception or target in Sunday's win over Miami. He played on 27 of the offense's 73 snaps.
#2 TE
Mo Alie-Cox: One reception in season opener
Sep 8th
Alie-Cox had one reception for 20 yards on his only target in Sunday's win over Miami.
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Titans News
#1 RDE
Jeffery Simmons: Gets raise via contract revision
Sep 15th
Simmons and the Titans agreed to terms Monday on a contract revision that provides him a $632,529 raise for the 2025 season, Adam Schefter of ESPN reports.
#1 TE
Chig Okonkwo: Makes four catches in loss
Sep 14th
Okonkwo recorded four receptions on six targets for 35 yards in Sunday's 33-19 loss to the Rams.
#2 WR
Elic Ayomanor: First career score
Sep 14th
Ayomanor recorded four receptions on six targets for 56 yards and a touchdown in Sunday's 33-19 loss to the Rams.
#1 WR
Calvin Ridley: Some impovement in Week 2
Sep 14th
Ridley recorded three receptions on six targets for 57 yards in Sunday's 33-19 loss to the Rams.
#1 K
Joey Slye: Connects on four FGAs in loss
Sep 14th
Slye went 4-for-4 on field-goal attempts and also made an extra-point try in Sunday's 33-19 loss to the Rams.
#1 QB
Cam Ward: Throws first TD
Sep 14th
Ward completed 19 of 33 passes for 175 yards, one touchdown and no interceptions in Sunday's 33-19 loss to the Rams. He added four rushes for eight yards.
#1 RB
Tony Pollard: Handles 20 carries
Sep 14th
Pollard rushed the ball 20 times for 92 yards in Sunday's 33-19 loss to the Rams. He was targeted once but did not record a reception.
#6 WR
Bryce Oliver: Nursing knee injury
Sep 14th
Oliver is questionable to return to Sunday's game against the Rams due to a knee injury, Turron Davenport of ESPN.com reports.
#1 RG
Kevin Zeitler: Exits with elbow injury
Sep 14th
Zeitler is questionable to return to Sunday's game against the Rams due to a left elbow injury, Turron Davenport of ESPN.com reports.
#2 FS
Kevin Winston: Won't play vs. LAR
Sep 14th
Winston (hamstring) is inactive for Sunday's game against the Rams, Jim Wyatt of the Titans' official site reports.
#3 RB
Kalel Mullings: Inactive Sunday
Sep 14th
Mullings (ankle) is inactive for Sunday's game against the Rams, Jim Wyatt of the Titans' official site reports.
#3 C
Corey Levin: Signed to active roster
Sep 13th
The Titans added Levin to their active roster from their practice squad Saturday, Jim Wyatt of the team's official site reports.
#1 RT
JC Latham: Missing Week 2
Sep 12th
Latham (hip) has been ruled out ahead of Sunday's matchup against the Rams, Jim Wyatt of the Titans' official site reports.
#4 WR
Chimere Dike: Larger role incoming?
Sep 12th
Head coach Brian Callahan told reporters Friday that Dike has earned more opportunities as a wide receiver, Jim Wyatt of the Titans' official site reports.
#1 NT
T'Vondre Sweat: Out for Week 2
Sep 12th
Sweat (ankle) has been ruled out for Sunday's game against the Rams, Jim Wyatt of the Titans' official site reports.
#1 RILB
Cedric Gray: Records eight tackles in loss
Sep 9th
Gray recorded eight tackles (five solo) in the Titans' loss to the Broncos on Sunday.
#1 RCB
Jarvis Brownlee: Piles up nine tackles in loss
Sep 9th
Brownlee recorded nine tackles (six solo) in the Titans' loss to the Broncos on Sunday.
#1 SS
Amani Hooker: Plays every snap vs. Denver
Sep 9th
Hooker logged five tackles (three solo) and one pass defense during the Titans' 20-12 loss to the Broncos on Sunday.
#1 LILB
Cody Barton: Logs nine tackles vs. former team
Sep 9th
Barton registered nine tackles (five solo) during the Titans' 20-12 loss to the Broncos on Sunday.
#2 TE
Gunnar Helm: One catch in regular-season debut
Sep 8th
Helm recorded one catch (on two targets) for 16 yards in Sunday's 20-12 loss to the Broncos.
#5 WR
Van Jefferson: Limited to seven snaps
Sep 8th
Jefferson was not targeted in Sunday's 20-12 loss to the Broncos.
#3 WR
Tyler Lockett: Uninvolved in Week 1
Sep 8th
Lockett didn't record a reception (on one target) in Sunday's 20-12 loss to the Broncos.
#2 RB
Julius Chestnut: Two touches in Week 1
Sep 8th
Chesnut rushed the ball twice for two yards in Sunday's 20-12 loss to the Broncos.
#1 SCB
Roger McCreary: Picks off Nix in Week 1 loss
Sep 8th
McCreary logged five tackles (four solo) and an interception during the Titans' 20-12 loss to the Broncos on Sunday.
#1 LCB
L'Jarius Sneed: Good to go vs. Denver
Sep 7th
Sneed (knee) is active for Sunday's game against the Broncos.