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Seahawks vs 49ers Odds, Lines, Spreads & Totals 2025

49ers
23.5 Pts
Seahawks
22.0 Pts
Sunday September 7, 2025 at 4:05 PM ET
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SF
49ers Injury Report
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SEA
Seahawks Injury Report
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SF
49ers Lineup
Inactives
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SEA
Seahawks Lineup
Inactives
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SF
49ers News
#1 RCB
Renardo Green: Suffers hamstring injury
Jul 25th
Green left Friday's practice due to a hamstring injury, Eric Branch of the San Francisco Chronicle reports.
#3 WR
Ricky Pearsall: Building endurance for camp
Jul 25th
Pearsall (hamstring) is considered healthy and just needs to build endurance before getting clearance for training camp, Ralph Vacchiano of Fox Sports reports.
#14 WR
Quintez Cephus: Headed to Bay Area
Jul 24th
The 49ers signed Cephus to a one-year contract Thursday, Jennifer Lee Chan of NBC Sports Bay Area reports.
#6 WR
Jacob Cowing: Pulls hamstring
Jul 23rd
Cowing pulled his hamstring Wednesday, Nick Wagoner of ESPN.com reports.
#1 K
Jake Moody: Facing competition for job
Jul 23rd
Moody is competing with Greg Joseph for San Francisco's placekicker job, David Lombardi of SFStandard.com reports.
#2 WR
Jauan Jennings: Practicing Wednesday
Jul 23rd
Jennings participated in individual drills at the start of Wednesday's practice, David Lombardi of SFStandard.com reports.
#1 LG
Ben Bartch: Dealing with quadriceps injury
Jul 22nd
Bartch is dealing with a quadriceps injury, Eric Branch of the San Francisco Chronicle reports.
#1 RB
Christian McCaffrey: Looking healthy at start of camp
Jul 22nd
Coach Kyle Shanahan said Tuesday that McCaffrey is "here and healthy" for the start of 49ers training camp, but the running back's workload will be managed in advance of the regular season, Nick Wagoner of ESPN.com reports.
#5 WR
Equanimeous St. Brown: Latches on with San Francisco
Jul 22nd
The 49ers signed St. Brown on Tuesday, Eric Branch of the San Francisco Chronicle reports.
#3 SLB
Curtis Robinson: Not healthy to open camp
Jul 18th
Robinson (undisclosed) was placed on the active/PUP list Friday.
#2 LDE
Yetur Gross-Matos: Sidelined to begin training camp
Jul 18th
Gross-Matos (undisclosed) was placed on the active/PUP list Friday.
#2 LT
Andre Dillard: Lands on PUP
Jul 18th
Dillard (undisclosed) was placed on the active/PUP list Friday.
#1 FS
Malik Mustapha: On PUP to begin camp
Jul 18th
Mustapha (knee) was placed on the active/PUP list by the 49ers on Friday.
#1 WR
Brandon Aiyuk: Moved to active/PUP list Friday
Jul 18th
Aiyuk (knee) was placed on the active/PUP list by the 49ers on Friday.
#3 QB
Kurtis Rourke: Begins camp on NFI
Jul 16th
The 49ers placed Rourke (knee) on the active/non-football injury list Wednesday, Matt Barrows of The Athletic reports.
SEA
Seahawks News
#3 RB
Kenny McIntosh: Suffers leg injury
Jul 26th
McIntosh suffered a leg injury during Seattle's practice Saturday, Gregg Bell of The Tacoma News Tribune reports.
#2 RB
Zach Charbonnet: Sharing backfield with Walker again
Jul 24th
Charbonnet and Kenneth Walker give Seattle backfield continuity in an otherwise revamped offense, ESPN.com's Brady Henderson reports.
#1 FB
Robbie Ouzts: Runs with first-team offense
Jul 23rd
Ouzts worked with the first-team offense during the Seahawks' first day of training camp Wednesday, Gregg Bell of The News Tribune reports.
#2 RCB
Shaquill Griffin: Sidelined by illness
Jul 23rd
Griffin did not practice Wednesday due to an illness, Michael-Shawn Dugar of The Athletic reports.
#2 SLB
Uchenna Nwosu: Not close to returning
Jul 23rd
Nwosu (knee) is not expected to be ready to practice anytime soon, Brady Henderson of ESPN.com reports.
#2 NT
Johnathan Hankins: Dealing with back injury
Jul 23rd
The Seahawks placed Hankins (back) on the active/non-football injury list Wednesday, Aaron Wilson of KPRC 2 Houston reports.
#1 RB
Kenneth Walker: Back to 100 percent
Jul 23rd
Coach Mike Macdonald said Wednesday that Walker (ankle) was a full practice participant to begin training camp, Brady Henderson of ESPN.com reports. "He looks great. He's in a great spot mentally," Macdonald added. "Awesome to see him do all the things we want him to do from the get-go. I know he's really excited about what's going on. Great first day with Ken."
#1 QB
Sam Darnold: Starting QB heading into camp
Jul 23rd
Darnold will take the first-team quarterback reps when training camp starts Wednesday, and there isn't a quarterback competition with rookie third-round pick Jalen Milroe, Brady Henderson of ESPN.com reports.
#2 TE
Elijah Arroyo: Door to starting job opens
Jul 21st
Arroyo will compete with AJ Barner for the starting tight end job after the Seahawks released Noah Fant on Sunday, Bob Condotta of The Seattle Times reports.
#1 TE
AJ Barner: Opportunity awaits
Jul 21st
Barner will compete with rookie Elijah Arroyo for the starting tight end job after the Seahawks released Noah Fant on Sunday, Bob Condotta of The Seattle Times reports.
#3 LCB
Isas Waxter: Activated off NFI list
Jul 16th
The Seahawks activated Waxter (undisclosed) off the active/non-football injury list Wednesday, John Boyle of the team's official site reports.
#3 LILB
D'Eryk Jackson: Activated off NFI list
Jul 16th
The Seahawks activated Jackson (undisclosed) off the active/non-football injury list Wednesday, John Boyle of the team's official site reports.
#12 WR
Montorie Foster: Activated off NFI list
Jul 16th
The Seahawks activated Foster (undisclosed) off the active/non-football injury list Tuesday, John Boyle of the team's official site reports.
#11 WR
Tyrone Broden: Activated off NFI list
Jul 16th
The Seahawks activated Broden (undisclosed) off the active/non-football injury list Wednesday, John Boyle of the team's official site reports.
#2 RDE
Rylie Mills: Placed on NFI list
Jul 15th
Mills (knee) was placed on the active/non-football injury list by the Seahawks on Tuesday, Corbin K. Smith of SI.com reports.