Wales really need all three points Tuesday against Moldova, which means they'll be relying heavily on the play of Gareth Bale.
The United States needs a result in Honduras on Tuesday to keep their World Cup hopes alive, and if they are to do it, Christian Pulisic is likely to play a big part.
Robert Lewandowski disappointed in last week's match against Denmark, but a return home to face Kazakhstan should bring fantasy fireworks Monday.
France had a solid win against the Netherlands earlier this week, and there is no reason to think they'll slow down Sunday against Luxembourg.
Netherlands struggled in their World Cup qualifier in France earlier this week, but Evan Morter explains why they should bounce back Sunday at home against Bulgaria.
Schuyler Redpath breaks down the Saturday MLS slate as Kaka likely will take on all of the set pieces for Orlando City.
Gareth Bale was whistled off the field in his last match for Real Madrid, but there should be plenty of cheers when he puts on the Wales shirt Saturday against Austria.
Gylfi Sigurdsson's recent game logs don't look particularly enticing, but Evan Morter explains why they should be ignored when considering him for Saturday's early WCQ slate.
The United States is favored in their match against Costa Rica on Friday, but Christian Pulisic doesn't come in with the highest goal scorer odds.
England are the biggest favorites on Friday's five-game slate, with their match against Malta likely to produce plenty of goals.
Christian Pulisic's hot start for Borussia Dortmund is giving Evan Morter plenty of confidence that the 18 year old will provide lots of fantasy points Friday against Costa Rica.
Despite playing on the road against Denmark, Evan Morter explains why fantasy players shouldn't fade Poland's Robert Lewandowski.
Brazil have already qualified for the World Cup, but fantasy managers should still be able to rely on Neymar if he gets a start against Ecuador.
Belgium will take on lowly Gibraltar on Thursday, and Romelu Lukaku could have a historic fantasy performance.
There are three gigantic favorites on Wednesday's five-game UEFA World Cup qualifying slate, with Portugal's Cristiano Ronaldo one of the elite stars in action.
Argentina have struggled in World Cup qualifying of late, and they'll need a big performance in a tough matchup in Uruguay from Lionel Messi.
Evan Morter picks the Saturday MLS slate on DraftKings as Miguel Almiron has a good chance against Philadelphia to bust out of his slump.
Romelu Lukaku is the top forward option on Saturday's five-game slate, and Kevin Swanson makes the case for fantasy players to pair him with Christian Benteke.