Arsenal are big favorites Saturday at home against Stoke City, which means Mesut Ozil will likely garner plenty of fantasy attention.
Real Madrid are still fighting for the top spot in their group, and Cristiano Ronaldo will now face off against a leaky Borussia Dortmund defense in Spain.
While Borussia Dortmund's matchup at Real Madrid doesn't appear great at first, Pierre-Emerick Aubameyang has been nearly unstoppable this season.
Lionel Messi is getting close to the Champions League group stage goals records, and with two hat tricks already in this year's competitions, he's easily the top player for Tuesday's slate.
Paris Saint-Germain are the biggest favorites for Tuesday's slate, which means Edinson Cavani will likely garner plenty of attention from fantasy managers.
With Philippe Coutinho and Daniel Sturridge out with injuries, Liverpool are going to have to rely on Sadio Mane to find the back of the net.
Harry Kane has the best odds to score Saturday, making the Spurs frontman a prime fantasy target.
Xherdan Shaqiri is still looking for his pre-injury form, but RotoWire's Tate McIntyre explains why it could come this weekend against Burnley.
Swansea City are big underdogs against Spurs at White Hart Lane, but RotoWire's Andrew Laird explains why Gylfi Sigurdsson is still worthy of fantasy consideration.
Spurs are the heaviest favorites on Saturday's six-game main slate, with the team providing plenty of enticing fantasy options in nearly all formats.
Sebastian Giovinco's upside is higher than some entire rosters without him, which is why RotoWire's JD Bazzo has no interest in fading the Toronto FC star.
James Milner has been one of the most consistent fantasy options this season, and his eligibility as a defender gives him that much more value.
Swansea City are still winless since Bob Bradley took the helm, but they are favored Saturday at home against Crystal Palace, putting Gylfi Sigurdsson firmly in play.
Saturday's five-game slate is highlighted by Spurs visiting Stamford Bridge to take on a Chelsea team that is the second-biggest favorite on the day.
Lionel Messi comes in as the most expensive player on the slate, but Alex Spalding has just the right players to pair with the Barcelona superstar without struggling with salary cap space.
There are a number of high-profile players available during Wednesday's six-game slate, but Man City's Kevin De Bruyne may be the best player at his position.
The MLS playoffs return Tuesday, as Sebastian Giovinco looks to make a statement for TFC on the road in Montreal.
Pierre-Emerick Aubameyang has been unstoppable this season, and there's little reason to think Legia Warsaw will be able to slow him down playing in front of the Yellow Wall on Tuesday.