CeeDee Lamb could have one of his biggest games playing against a Lions defense that's tougher against the run than the pass.
DK Metcalf could pose a major big-play threat to Tennessee's injury-challenged corner rotation.
If New England prioritizes defending Travis Kelce then the Pats might not have leftover personnel to cover Rashee Rice.
The Saints are tougher on the boundary than in the slot, which should provoke a big game from Amon-Ra St. Brown.
A.J. Brown and DeVonta Smith are glaring mismatches against the Dolphins corners, setting the stage for a runaway shootout.
It might be now or never for DeAndre Hopkins, who catches the Colts battered and weak at cornerback.
The Dolphins are looking to bring a shootout to the Bills, but Stefon Diggs is prepared to shoot back against Miami's questionable pass defense.
Drake London is due for a bounce-back after no catches in Week 1, but Jaire Alexander could deny it anyway.
The Colts' cornerback personnel is weak but their run defense is strong, setting up a feast for Calvin Ridley and the Jags passing game.
Mike Williams should climb the ladder against Tennessee CBs that lack reach.
Amon-Ra St. Brown is providing monstrous late-season production again and should continue against Minnesota.
A.J. Brown has both a good matchup and the Revenge Game narrative in Week 13.
Xavien Howard is more of a ballhawk than a shutdown corner, so Amari Cooper should do well in the warm weather Sunday.
Sauce Gardner vs. Stefon Diggs would be an interesting matchup, but the Bills should be able to keep Diggs away from Gardner.
Justin Fields had a big October, at least from a fantasy standpoint, and now he gets more help at wide receiver for his Week 9 matchup with a reeling Dolphins defense.
It's been a difficult season for DJ Moore, but the Falcons are vulnerable without top CB A.J. Terrell.
With better coverage in the seam than the perimeter, expect Mike Evans to hit the ground running against the Chiefs.
Mario Puig analyzes the wide receiver-cornerback matchups for Week 3. Allen Robinson is poised to finally break out after a slow two-week start to his Rams career.