Ty Chandler's impressive Week 15 performance could keep him in the lead role even if Alexander Mattison returns from an ankle injury soon.
Chicago's D'Onta Foreman retook the the lead role -- ahead of Khalil Herbert and Roschon Johnson -- in his first game back from an ankle injury.
Roschon Johnson took over the lead role Monday night, but it's unclear if that will hold after a Week 13 bye.
AJ Dillon struggled in a lead role earlier this season, but he's played better recently and now gets another chance to replace an injured Aaron Jones as Green Bay's starting running back.
Erik Siegrist previews the Monday night matchup as Patrick Mahomes and the Chiefs take on the Eagles.
Will the Chiefs' offense get their mojo back after the bye week against the Eagles?
Devin Singletary's huge game in Cincinnati may have been enough to displace Dameon Pierce from the starting role once he returns from an ankle injury.
Keaton Mitchell is a tough player to rank this week because of the Ravens' timeshare at RB and the tough opponent this week.
Zach Charbonnet took more snaps than Kenneth Walker again, and the Ravens introduced a lightning-fast rookie into their RB rotation.
Aaron Jones finally got back to a high-usage role after nearly two months of being held back by a hamstring injury.
Chuba Hubbard dominated Carolina's backfield work even with Miles Sanders back in the lineup, and Denver's Javonte Williams returned to a workhorse role against the Chiefs.
Can A.J. Brown keep it rolling in a showdown against the tough Cowboys defense?
Dan Marcus analyzes the DFS contests for the Thursday matchup as Stefon Diggs looks for another elite outing.
Dan Marcus goes deep into the free-agent pool to find upside adds who could pay off down the road, if not this week.
Travis Etienne has been a constant for the Jaguars even when they've had a tough matchup.
Emari Demercado will be one of the top waiver adds for a second time in three weeks after his ascension to a lead role came a week later than many expected.
The NFC West was full of interesting developments Week 7, including RBs Darrell Henderson and Emari Demercado ascending to lead roles for their respective teams.
Erik Siegrist analyzes the Monday night matchup as Brock Purdy and the 49ers hope to rebound at Minnesota.