NFL Wild Card Round Odds & Staff Predictions for All 6 Games (2026 NFL Playoffs)

The 2025-26 NFL Playoffs are just a few days away. If you're looking to stay up to date on the latest odds and predictions for the Wild Card Round, the RotoWire staff has you covered. Below, you'll find a quick-hitting breakdown of the latest odds and our staff's expert prediction for each game on Wild Card Weekend. 

And make sure you check out the Best Wild Card Round Anytime TD Bets as well. 

Latest NFL Odds: Wild Card Round

All odds listed in the section below are courtesy of bet365. Be sure to use a bet365 bonus code to make the most of your bets. Note that odds may change after this article is published. 

What Game Has the Biggest Point Spread in the Wild Card Round? 

The Los Angeles Rams are the biggest favorites of the Wild Card Round, as most sportsbooks have them as 10.5-point favorites over the Carolina Panthers. Notably, Carolina defeated LA in the lone meeting between these two earlier this season. 

• ⭐️ For prop bettors: Best Wild Card Round Player Props

What Game Has the Smallest Point Spread in the Wild Card Round? 

There are two games with just a 1.5-point spread in the Wild Card Round at most sportsbooks. The Green Bay Packers are slim 1.5-point favorites over the Chicago Bears, and the Buffalo Bills are favored by 1.5 over the Jacksonville Jaguars. Both teams enter this matchup as road favorites. 

What Game Has the Highest Over/Under in the Wild Card Round? 

The highest over/under in the Wild Card Round is the 51.5-point over/under in the Bills vs Jaguars game. It's a full five points higher than any other matchup on the slate this week. Fans should expect a ton of points between Josh Allen and Trevor Lawrence on Sunday. 

What Game Has the Lowest Over/Under in the Wild Card Round? 

The lowest over/under in the Wild Card Round belongs to the 38.5-point over/under in the Texans vs Steelers game. This number suggests fans could be in for a defensive slugfest and a low-scoring game to close out Wild Card Weekend. 

Expert Predictions for NFL Wild Card Round

We asked four RotoWire Staff members to make a moneyline prediction for each of the six matchups on Wild Card Weekend. Here are the results: 

Panthers vs Rams Staff Predictions

No disagreement here – all four RotoWire staff members are picking the Rams to beat the Panthers. 

• ⭐️ For in-depth analysis: Rams vs Panthers Predictions and Odds

Bears vs Packers Staff Predictions

This one is not quite as cut-and-dry, but there's still a clear consensus. Three of the four RotoWire staff members are taking the Packers to beat the Bears. 

• ⭐️ For in-depth analysis: Packers vs Bears Predictions and Odds 

Jaguars vs Bills Staff Predictions 

Interestingly, the four RotoWire experts all agree on what is widely considered one of the most divisive games of the week. All four are picking the Bills to beat the Jaguars. 

• ⭐️ For in-depth analysis: Bills vs Jaguars Predictions and Odds

Eagles vs 49ers Staff Predictions 

Surprisingly, three of the four staff members are predicting an upset, taking the 49ers to beat the Eagles. I was the lone holdout of the bunch. I finished with the worst regular-season prediction record of all four staff members. Do with that what you will. 

⭐️ For in-depth analysis: 49ers vs Eagles Predictions and Odds

Patriots vs Chargers Staff Predictions 

Three of the four experts are taking the Patriots to beat the Chargers in Foxborough. The lone holdout was Brandon Justice, who finished with the best regular-season record of the bunch. 

⭐️ For in-depth analysis: Chargers vs Patriots Predictions and Odds 

Steelers vs Texans Staff Predictions 

There's a clear trend with the final game of Wild Card Weekend, as three of the four staff members are picking the Texans to beat the Steelers. 

⭐️ For in-depth analysis: Texans vs Steelers Predictions and Odds 

Where to Bet on NFL Playoffs Odds: Wild Card Round

Below, I've listed the top sportsbooks that offer betting markets on these games. I've also included their welcome offers, so you can kickstart your account with some bonus bets.