Portugal disappointed in their Euro 2020 qualification opener last week, and they'll have a tough task bouncing back against Serbia.
Kylian Mbappe has been unstoppable this season, and there's little reason to think Iceland will be able to shut him down in their Euro 2020 qualifier.
Germany are in a bit of transition as they open their Euro 2020 qualification campaign against the Netherlands, but they'll likely continue to rely on Marco Reus to make an impact.
Wales will be without Aaron Ramsey for their Euro 2020 qualifier against Slovakia, putting more pressure on the shoulders of Gareth Bale.
Sweden host Romania in their first Euro 2020 qualifying match Saturday, and they will need Emil Forsberg to step up.
Spain are heavily favored at home against Norway in their opening Euro 2020 qualifier, with La Roja expecting another solid performance from Sergio Ramos.
Cristiano Ronaldo is finally back with the Portugal squad, and he's expected to make a big impact at home against Ukraine.
England begin their Euro 2020 qualification at home against Czech Republic on Friday, a match they'll surely need Harry Kane to step up in.
Andrew Laird, JD Bazzo and Daniel Bramlette preview Saturday's three-game MLS slate on DraftKings, including just how viable Nani is for Orlando City playing at the Red Bulls.
LA FC have one of the easiest matchups of the season in a shortened Week 4, which helps put Carlos Vela, Adama Diomande and Diego Rossi high in JD Bazzo's weekly positional rankings.
Poland are expected to get a result Thursday against Austria, but they'll need a solid performance from Robert Lewandowski to accomplish that.
Belgium kick off their Euro 2020 qualification against Russia on Thursday, and Ajay Patil is expecting a big performance from Eden Hazard.
Kylian Mbappe has been absolutely dominant during Ligue 1 play this season, and Marseille will surely have their hands full trying to slow him down Sunday.
There is no denying Lionel Messi will be expected to make an impact Sunday against Betis, but Azeem Siddiqui sees a number of other key players who can contribute.
Eden Hazard has struggled of late, but Chelsea will need him to step up if they are to get a result at Goodison Park on Sunday.
Given Mohamed Salah's struggles lately and his own excellent form, Ajay Patil is giving the captain's armband to Sadio Mane on Sunday.
Cristiano Ronaldo bagged a hat trick earlier this week against Atletico Madrid in the Champions League, and he'll look to extend his fine form Sunday against Genoa.
Liverpool have a solid matchup away to Fulham on Sunday, and RotoWire's Adam Zdroik discusses the possibility of playing all three of their forwards together in a fantasy lineup.