Friday's two-game slate doesn't include an overwhelming favorite, which means fantasy players should be able to diversify their lineups.
Josef Martinez has 24 goals in 23 games this season, including nine in his last five, and RotoWire's JD Bazzo is expecting his red-hot play to continue Saturday against Toronto.
Many fantasy managers focus on attacking fullbacks for their potential assist upside, but RotoWire's Andrew Laird says not to forget about center-backs who can actually put the ball in the back of the net.
It will be tough to get off to a strong start in the fall season if you miss on your captain selection, which is why RotoWire's Adam Zdroik may turn to Josef Martinez.
Andrew Laird and JD Bazzo preview the opening weekend of the MLS Fantasy Fall Season, including a discussion about whether to focus on raw points or price rises, and how aggressive fantasy players should be because of the shorter schedule.
Manchester City are stacked with high-scoring fantasy options, but fantasy players might be able to get some value out of low-priced Fernandinho early in the season.
Tigres and Monterrey are the favorites on Sunday's two-game slate, which means Andre-Pierre Gignac could be a popular option.
With Romain Alessandrini suspended due to yellow card accumulation, the Galaxy will need to rely even more on Zlatan Ibrahimovic in their attack.
The Galaxy are big favorites at home against Orlando City on Sunday, and fantasy players are likely to give a long, hard look toward Zlatan Ibrahimovic.
Houston could have a tough time against the Timbers in Portland on Saturday, but they always have a chance with the dangerous Alberth Elis in their attack.
Club America are big favorites at home to Atlas on Saturday, while the Chivas-Cruz Azul match expected to be very close.
Diego Valeri has been churning out the fantasy points this season, and RotoWire'e Schuyler Redpath thinks he'll keep it going Saturday against Houston.
Toronto FC is the big favorite on Saturday's slate, with the oddsmakers naturally expecting Sebastian Giovinco to have a big impact.
Both away teams are favored on Friday's two-game Liga MX slate, but that doesn't mean fantasy players should be avoiding hosts Morelia and Puebla.
David Villa could return from injury Thursday, and the oddsmakers are expecting him to have a big impact on the road at Orlando City.
The Red Bulls are favored away to D.C. United on Wednesday, which is likely to get plenty of people looking to Bradley Wright-Phillips for at least one goal.
D.C. United will play two games this week, and while some people may consider giving the captain's armband to Wayne Rooney, RotoWire's Adam Zdroik thinks Yamil Asad is the much better option.
New York City FC will play two games in Week 22, but that isn't quite enough to make Maximiliano Moralez the top midfielder in JD Bazzo's weekly positional rankings.