Despite playing on the road, Antoine Griezmann has the best anytime goal scorer odds among Wednesday's four teams.
Manchester City and Stoke City have double gameweeks, which means players from both teams move up in our weekly rankings, with Sergio Aguero unsurprisingly at the top of one.
Manchester City will play twice in Gameweek 27, and while many fantasy managers will be looking to Sergio Aguero for the captain's armband, Adam Zdroik says don't forget about Raheem Sterling.
Liverpool v. Arsenal is the highlight match of Saturday's six-game slate, with goals expected after the two sides scored seven in their first meeting this season.
The Timbers are significantly better when they play at Providence Park, and they'll kick off the new season against expansion franchise Minnesota United, putting Diego Valeri firmly in play as a fantasy captain.
Major League Soccer returns this weekend, which means Sebastian Giovinco returns to his regular spot atop one of our weekly positional rankings.
He's long been a proponent of fading goal-dependent forwards, but Jordan Cooper explains why he ended up with Diego Costa in his lineup last weekend.
Lionel Messi is always a popular fantasy option, and his ownership could be even higher Wednesday because oddsmakers are giving him an 80 percent chance to score at least once.
Andrew Laird and Mike Gottlieb review Gameweek 26 of the Premier League, including which team is the most exciting to watch when they play at their best. Hint: Harry Kane won't be happy with the answer.
Tuesday's two-game Interleague slate includes four La Liga teams, though without Real Madrid, Barcelona and Atletico Madrid on the schedule, fantasy managers will need to dig deep for fantasy points.
Sadio Mane has scored three goals in his last three starts, and he'll look to extend his streak Monday against Leicester City at the King Power Stadium.
Despite playing away from home, Real Madrid are still heavy favorites Sunday against Villarreal, which means Cristiano Ronaldo should get plenty of fantasy attention.
Harry Kane has four goals in his last two home games, and he has a great opportunity to extend his streak Sunday against Stoke City at White Hart Lane.
Juventus are the biggest favorites on Saturday's four-game interleague slate, which means plenty of fantasy managers will be focusing on Gonzalo Higuain.
Andrew Laird and Chris Owen break down the upcoming weekend of Premier League matches, including whether it's okay to fade Chelsea and which mid-tier midfielders could provide the best value.
With Mario Balotelli suspended and Alassane Plea out with a knee injury, someone will have to step up for Nice as they take on Montpellier at home.
Eden Hazard has been an up-and-down fantasy option this season, but Kevin Swanson explains why the Chelsea midfielder should make an impact Saturday against Swansea City.
Romelu Lukaku bagged a hat trick at Sunderland earlier this season, and he'll get a shot to repeat the feat this weekend at Goodison Park.