There much to be decided in the home stretch of the MLB regular season, and much to be decided on the DFS front Wednesday. Everything, in fact, including your potential success. There are 10 games on the DFS docket, with the first pitch at 6:40 p.m. EDT. Having looked over the matchups, here are my MLB DFS lineup recommendations for Wednesday.
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Pitching
Brandon Woodruff, MIL vs. LAA ($10,800): Woodruff has had a little extra time off, which is fair given that he started the season injured and the Brewers have to consider the postseason. Through 11 starts, though, Woodruff has a 3.26 FIP and 11.16 K/9 rate. I assume Woodruff hasn't forgotten how to pitch owing to a few extra days off, and the Angels are in the bottom 10 in runs scored.
Jacob deGrom, TEX at HOU ($10,200): DeGrom should get to 30 starts, and he's already made his most starts since 2019, and that's cool in and of itself. Beyond that, though, he has a 2.82 ERA and 4.89 K/BB rate, and he's held both righties and lefties under the Mendoza line. The Astros may finish in the bottom 10 in runs scored, and right now both Yordan Alvarez and Jose Altuve are managing injuries.
Luis Gil, NYY at MIN ($8,400): Even though he had to wait a while due to injury, Gil is showing that winning AL Rookie of the Year in 2024 was no fluke. His first start back was rough, but that's not unreasonable. Since then, though, Gil has an 1.89 ERA in seven starts. The bottom five in runs scored is a set quintet, but the Twins are one of the teams primed to finish in the bottom 10 than could easily finish 26th.
Top Targets
All told, Bobby Witt ($4,000) has had an excellent season, and the second-best season of his career. It just happens to be a campaign in the wake of an incredible, MVP-caliber season. The righty has crossed 20 homers, 30 stolen bases, and 40 doubles. While he won't hit .300 again, hitting .292 in 2025 is still impressive. Bryce Miller has collapsed this season, and he has a 5.59 ERA. In the past, though, he's relied on his home ballpark for success. To that end, he has a 4.76 ERA on the road since 2023.
While Witt still seems like a guy primed to win an MVP some day, Julio Rodriguez ($4,000) has fallen off that trajectory. However, in 2025 he's at least bounced back to looking like a perennial All-Star, and that's not too shabby. He has 30 homers and 30 doubles, and he might get to 30 stolen bases. Seattle's ballpark has consistently hurt his offense – he's not alone in that – but on the road he has a .926 OPS. Cole Ragans was very good last year, and he has a 2.46 FIP compared to a 5.18 ERA in 2025. That being said, he's been out since June 5 with a shoulder injury, so I have questions about how the lefty will look, or what his pitch count will be.
Bargain Bats
As a baseball player, Brenton Doyle ($3,300) has some egregious issues. As a DFS bargain bat, he offers value in a very specific circumstance. Namely, when he is facing a lefty at home. Doyle has an .864 OPS against southpaws and an .886 OPS at Coors Field this season. Ryan Weathers is a lefty, and he has a career 1.55 HR/9 rate. Doyle can't draw a walk to save his life, but he's going to manage a 15/15 season thanks to Coors and southpaws.
Though Josh Smith ($3,000) doesn't have a ton of power, he has 23 doubles, two triples, and 12 stolen bases in 137 games. He provides positional versatility, as well as a .271 average against righties. While Cristian Javier's 4.78 ERA comes in only six starts, since 2023 lefties have hit .276 against him so that provides more encouragement.
Stacks to Consider
Padres at Mets (David Peterson): Fernando Tatis ($3,700), Manny Machado ($3,500), Ramon Laureano ($3,000)
While Peterson hasn't completely collapsed like some Mets starters, and while he's still avoided homers as per usual, his performance has tailled off. Over his last seven starts he has a 7.13 ERA. Okay, so maybe he has collapsed (but the homers part is still definitely true). Peterson is a southpaw, and since 2023 righties have hit .266 against him. On top of that, right-handed hitters have tallied nine of the 10 homers that the Mets hurler has allowed in 2025.
While Tatis hasn't provided the power he showed in the first few years of his career, but he has 22 homers to go with his 30 stolen bases. He also has an .805 OPS over the last three weeks, as well as an .854 OPS over the last two weeks. Machado has ended up primed to have roughly the same season he had in 2024. That's not a bad thing, as in 2025 the third baseman has a .277 average with 25 homers and 13 swiped bags. Machado has also been slightly better on the road this year, as he has an .815 OPS in away games. Though Laureano has slowed down a bit compared to what he did with the Orioles prior to being traded, he's still hit eight home runs and two triples with the Padres in only 42 games. He's also a proven success against southpaws, as he's slugged .511 against them since 2023.
Marlins at Rockies (McCade Brown): Otto Lopez ($3,300), Liam Hicks ($2,900), Connor Norby ($2,900)
The Marlins don't offer the best stack options, but I was willing to look for a trio to consider. This game is at Coors Field, for starters. In four starts with the Rockies, Brown has a 9.88 ERA, 1.11 K/BB rate, and 1.98 HR/9 rate. Both lefties and righties have hit well over .300 against him for good measure. That's why it was worth figuring out a stack for me.
Lopez has 14 homers and 13 stolen bases. Over the last three weeks he's hit .310, and that bodes well with what Coors Field can do for balls in play. Hicks doesn't have much power, but he has a .347 OBP versus righties, as well as a .358 OBP on the road. Over half of his hits have qualified as "medium" power, so perhaps he will hit a double or two Wednesday. Norby has just returned from the IL, and in 78 games he has six homers, 14 doubles, and seven stolen bases. He's also hit .283 against righties as well.
