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Buccaneers vs 49ers Odds, Lines, Spreads & Totals 2025

49ers
22.3 Pts
Buccaneers
25.3 Pts
Sunday October 12, 2025 at 4:25 PM ET
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49ers Injury Report
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Buccaneers Injury Report
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49ers Lineup
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49ers News
#3 FS
Malik Mustapha: Practice window opened
Oct 6th
The 49ers opened Mustapha's (knee) 21-day practice window to return from the reserve/PUP list.
#1 RCB
Deommodore Lenoir: Six tackles in TNF win
Oct 3rd
Lenoir registered six tackles (two solo) and one pass defense during the 49ers' 26-23 overtime win over the Rams.
#1 WLB
Dee Winters: Tallies four tackles
Oct 3rd
Winters registered four tackles (three solo) during Thursday's 26-23 overtime win over the Rams.
#1 SS
Marques Sigle: Team-high 13 tackles in Week 5 win
Oct 3rd
Sigle registered 13 tackles (seven solo) and one pass defense during Thursday's 26-23 overtime win over the Rams.
#1 MLB
Fred Warner: Tallies 12 tackles in TNF victory
Oct 3rd
Warner logged 12 tackles (seven solo) during the 49ers' 26-23 overtime win over the Rams on Thursday.
#2 LDE
Yetur Gross-Matos: Set to miss 'some time'
Oct 3rd
Coach Kyle Shanahan said Friday that Gross-Matos will miss some time with a strained hamstring, Nick Wagoner of ESPN.com reports.
#1 SCB
Upton Stout: Nursing ankle injury
Oct 3rd
Head coach Kyle Shanahan relayed Friday that Stout is considered day-to-day due to an ankle sprain that he suffered during the 49ers' 26-23 overtime win over the Rams on Thursday, Nick Wagoner of ESPN.com reports.
#2 LDT
Alfred Collins: Sustains knee sprain in Week 5 win
Oct 3rd
Collins sprained his knee during the 49ers' 26-23 overtime win over the Rams on Thursday, Nick Wagoner of ESPN.com reports.
#4 TE
George Kittle: Expected to remain out for Week 6
Oct 3rd
San Francisco head coach Kyle Shanahan said Friday that Kittle (hamstring) is considered a "long shot" to be available for the team's Week 6 game against the Buccaneers, but the tight end could be more likely to return from injured reserve for a Week 7 matchup with the Falcons on Sunday, Oct. 19, Adam Schefter of ESPN reports.
#1 FB
Kyle Juszczyk: Season high in touches Thursday
Oct 3rd
Juszczyk had one carry for a loss of one yard and three receptions on four targets for 21 yards in Thursday's 26-23 overtime win over the Rams.
#5 WR
Skyy Moore: One carry on offense Thursday
Oct 3rd
Moore had one carry for one yard without being targeted in Thursday's 26-23 win over the Rams.
#3 RB
Isaac Guerendo: Returns one kickoff Thursday
Oct 3rd
Guerendo ran back one kickoff for 18 yards while receiving no carries or targets in Thursday's 26-23 overtime win over the Rams.
#2 RB
Brian Robinson: Held to 12 yards Thursday
Oct 3rd
Robinson rushed five times for 12 yards and was not targeted in Thursday's 26-23 overtime win against the Rams.
#1 LDT
Kalia Davis: Undergoes surgery
Oct 3rd
Davis (hand) is set to undergo surgery after breaking his hand in Thursday's 26-23 win over the Rams, Ian Rapoport of NFL Network reports.
#1 QB
Brock Purdy: Could miss additional time
Oct 3rd
Head coach Kyle Shanahan confirmed after Thursday's 26-23 overtime victory over the Rams that Purdy is without a timeline for a return after a recent MRI revealed that he aggravated a turf toe injury in the Week 4 loss to the Jaguars, Ian Rapoport of NFL Network reports. "He's week-to-week," Shanahan said of Purdy. "Don't know how [the toe] will heal."
#4 WR
Demarcus Robinson: Trio of grabs in elevated role
Oct 2nd
Robinson brought in three of seven targets for 39 yards in the 49ers' 26-23 overtime win over the Rams on Thursday night.
#1 TE
Jake Tonges: Involvement boosted in OT win
Oct 2nd
Tonges secured seven of 11 targets for 41 yards and a touchdown in the 49ers' 26-23 overtime win over the Rams on Thursday night.
#3 WR
Kendrick Bourne: Career-best yardage in OT win
Oct 2nd
Bourne brought in 10 of 11 targets for 142 yards in the 49ers' 26-23 overtime win over the Rams on Thursday night.
#2 QB
Mac Jones: Gutsy effort in Week 5 OT win
Oct 2nd
Jones completed 33 of 49 passes for 342 yards with two touchdowns and no interceptions while adding four rushes for five yards in the 49ers' 26-23 overtime win over the Rams on Thursday night.
#1 RB
Christian McCaffrey: Tallies 30 touches in OT win
Oct 2nd
McCaffrey rushed 22 times for 57 yards and brought in eight of nine targets for 82 yards and a touchdown in the 49ers' 26-23 overtime win over the Rams on Thursday night.
#1 K
Eddy Pineiro: Busy night during TNF
Oct 2nd
Pineiro went 4-for-4 on field-goal tries and made both of his extra-point attempts in Thursday's 26-23 overtime win over the Rams.
#2 DT2
CJ West: Good to go Week 5
Oct 2nd
West (thumb) is active for Thursday's game against the Rams, Briana Jeannel of the 49ers' official site reports.
#4 RB
Jordan James: Healthy scratch again
Oct 2nd
James (coach's decision) is inactive for Thursday night's game against the Rams, Briana Jeannel of the 49ers' official site reports.
#3 QB
Adrian Martinez: Signed to Niners' active roster
Oct 2nd
The 49ers signed Martinez from the practice squad to the active roster ahead of Thursday's game against the Rams.
#3 LDE
Robert Beal: No go for TNF
Oct 1st
Beal (groin) has been ruled out for Thursday night's contest against the Rams, Matt Barrows of The Athletic reports.
#1 LCB
Renardo Green: Good to go for Thursday night
Oct 1st
Green (neck) doesn't carry an injury designation into Thursday night's game against the Rams, Matt Barrows of The Athletic reports.
#7 WR
Jordan Watkins: Ruled out for TNF
Oct 1st
Watkins (calf) has been ruled out for Thursday night's game against the Rams, Matt Barrows of The Athletic reports.
#2 WR
Ricky Pearsall: Won't play Thursday
Oct 1st
Pearsall (knee) is ruled out for Thursday's game against the Rams, Matt Maiocco of NBC Sports Bay Area reports.
#1 WR
Jauan Jennings: Ruled out for TNF
Oct 1st
Jennings (ankle, ribs) is ruled out for Thursday's matchup against the Rams, Matt Maiocco of NBC Sports Bay Area reports.
#6 WR
Marquez Valdes-Scantling: Not playing Week 4
Sep 28th
Valdes-Scantling (coach's decision) is inactive for Sunday's game against the Jaguars.
#3 RDE
Nick Bosa: Undergoes successful surgery
Sep 26th
Bosa (knee) underwent surgery to address his torn ACL on Friday, Cam Inman of The San Jose Mercury News reports.
#8 WR
Brandon Aiyuk: Not close to returning from PUP
Sep 25th
San Francisco GM John Lynch said Thursday that Aiyuk (knee, PUP) is "not close" to returning, David Lombardi of SFStandard.com reports.
#1 RDE
Mykel Williams: Practices in full
Sep 24th
Williams logged a full practice session Wednesday, Matt Barrows of The Athletic reports.
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Buccaneers News
#1 SS
Antoine Winfield: Three tackles vs. Seattle
Oct 6th
Winfield logged three tackles (one solo) and one pass defense during Sunday's 38-35 win over the Seahawks.
#1 FS
Tykee Smith: Logs six tackles in Week 5 victory
Oct 6th
Smith registered six tackles (two solo) and two pass defenses during Sunday's 38-35 win over Seattle.
#1 RILB
Lavonte David: Clutch interception in Week 5 win
Oct 6th
David logged nine tackles (five solo) and one interception during the Buccaneers' 38-35 win over the Seahawks on Sunday.
#1 SCB
Jacob Parrish: Racks up tackles in win
Oct 6th
Parrish recorded nine tackles (five solo) in the Buccaneers' 38-35 win over the Seahawks on Sunday.
#4 RB
Josh Williams: Serves as kickoff returner in win
Oct 6th
Williams returned five kickoffs for 129 yards in the Buccaneers' 38-35 win over the Seahawks on Sunday.
#5 WR
Tez Johnson: Makes presence known in win
Oct 6th
Johnson secured all four targets for 59 yards in the Buccaneers' 38-35 win over the Seahawks on Sunday.
#3 RB
Sean Tucker: Does little with six touches
Oct 6th
Tucker rushed three times for three yards and brought in all three targets for minus-4 yards in the Buccaneers' 38-35 win over the Seahawks on Sunday.
#4 WR
Sterling Shepard: Nabs first TD reception of 2025
Oct 5th
Shepard finished with four receptions on five targets for 24 yards and a touchdown while losing five yards on his only rushing attempt in Sunday's 38-35 win over Seattle.
#1 TE
Cade Otton: Gains 81 yards Sunday
Oct 5th
Otton had four receptions on five targets for 81 yards in Sunday's 38-35 win over the Seahawks.
#2 WR
Chris Godwin: Held to three catches in shootout
Oct 5th
Godwin had three receptions on four targets for 26 yards in Sunday's 38-35 win over the Seahawks.
#1 K
Chase McLaughlin: Makes every kick Sunday
Oct 5th
McLaughlin hit all three field-goal tries and all three extra-point attempts in Sunday's 38-35 win over the Seahawks.
#2 RB
Rachaad White: Scores twice in spot-start Sunday
Oct 5th
White took 14 carries for 41 yards and a pair of touchdowns while adding 30 yards on four receptions in Sunday's 38-35 win over the Seahawks.
#1 QB
Baker Mayfield: Dissects defense in late comeback
Oct 5th
Mayfield completed 29 of 33 pass attempts for 379 yards and two touchdowns while rushing five times for 15 yards in Sunday's 38-35 win over the Seahawks.
#3 WR
Emeka Egbuka: Career-high 163 yards in win
Oct 5th
Egbuka finished with seven receptions on as many targets for 163 yards and a touchdown in Sunday's 38-35 win over Seattle.
#1 RB
Bucky Irving: Likely to remain out through Week 6
Oct 5th
Irving (foot/shoulder), who has been ruled out for Sunday's game against the Seahawks, is likely to remain sidelined for the Buccaneers' Week 6 contest versus the 49ers on Oct. 12, Adam Schefter of ESPN reports.
#2 LCB
Benjamin Morrison: Won't suit up against Seahawks
Oct 3rd
Coach Todd Bowles said Friday that Morrison (hamstring) is out for Sunday's game at Seattle, Scott Smith of the Buccaneers' official site reports.
#2 SS
Christian Izien: Won't play at Seattle
Oct 3rd
Coach Todd Bowles said Friday that Izien (quadriceps) is out for Sunday's game against the Seahawks, Scott Smith of the Buccaneers' official site reports.
#1 LCB
Jamel Dean: Out for Week 5
Oct 3rd
Dean (hip) has been ruled out ahead of Sunday's matchup against the Seahawks, Scott Smith of the Buccaneers' official site reports.
#1 WR
Mike Evans: Out for Week 5
Oct 3rd
Coach Todd Bowles officially ruled out Evans (hamstring) for Sunday's game in Seattle, Scott Smith of the Buccaneers' official site reports.
#1 ROLB
Haason Reddick: Practices Thursday
Oct 2nd
Reddick (neck) was a full participant in Thursday's practice session.
#2 RDE
Greg Gaines: Full practice Thursday
Oct 2nd
Gaines (pectoral) was a full participant at practice Thursday.
#1 LT
Tristan Wirfs: Full participant Thursday
Oct 2nd
Wirfs (knee) was a full participant in practice Thursday.
#7 WR
Kameron Johnson: Big day on returns vs. Eagles
Oct 1st
Johnson returned two kickoffs for 42 yards and ran back six punts for 100 yards during the Buccaneers' 31-25 loss to the Eagles in Week 4.
#1 RCB
Zyon McCollum: Records four stops Sunday
Sep 30th
McCollum tallied four tackles (all solo) in Sunday's Week 4 loss to Philadelphia.
#1 LILB
SirVocea Dennis: Posts eight stops in Week 4 loss
Sep 30th
Dennis finished Sunday's loss to the Eagles with eight tackles (six solo).
#3 FS
Rashad Wisdom: Lands on injured reserve
Sep 30th
The Buccaneers placed Wisdom (quadriceps) on injured reserve Tuesday, Scott Smith of the team's official site reports.
#1 RDE
Logan Hall: Green light to play vs. Philly
Sep 28th
Hall (groin) is active for Sunday's game against the Eagles.
#6 WR
Ryan Miller: No stats in Week 3 win
Sep 25th
Miller failed to bring in his only target over 18 snaps in the Buccaneers' Week 3 win over the Jets, but he could be in line for a bigger role in Sunday's Week 4 matchup against the Eagles in the wake of Mike Evans missing the last two days of practice due to a hamstring injury, per Brianna Dix of the team's official site.