Valencia and Maccabi, both missing several key players, bring Round 25 to a close at 3:00 ET.
A pair of teams currently in playoff position will match up when Adam Hanga and Barcelona head to Greece to take on Panathinaikos.
Friday's action gets underway when Billy Baron and Crvena Zvezda host CSKA at 1:00 ET.
Zach LeDay and Zalgiris take on Baskonia in the final game on Thursday's schedule.
Gustavo Ayon and Zenit host ALBA as EuroLeague action resumes Thursday.
Milan squares off against Ante Tomic and Barcelona in the final game before a two-week break in the action.
Friday's action gets underway as Crvena Zvezda heads to Russia to take on Jonas Jerebko and Khimki.
Future NBA Draft lottery pick Theo Maledon and ASVEL head to Spain to take on Baskonia and bring Thursday's action to a close.
Zalgiris has played well since the calendar flipped to 2020, but they will face their toughest test of the new year when they take on Chris Singleton and Efes in Round 24.
Alberto Abalde and Valencia bring Round 23 to a close when they host Barcelona on Wednesday.
Evgeny Voronov and Zenit take on Fenerbahce in the first game on Wednesday's schedule.
Baskonia won't have to travel far to take on Walter Tavares and Real Madrid in Round 23.
A pair of MVP candidates match up in Moscow on Tuesday as Mike James (pictured) and CSKA host Shane Larkin and Efes.
DeShaun Thomas and Panathinaikos head to Spain to take on Valencia and close out Round 22.
Shane Larkin will be seeking a FIFTH! straight Round MVP honor when Efes squares off against Red Star on Friday.
Kaleb Tarczewski will look to keep things rolling when he and his Milan teammates host Bayern on Thursday.
Anthony Gill and Khimki defend their home court against CSKA as Round 22 tips off.
Milan heads to Turkey to take on Kostas Sloukas and Fenerbahce with a lot on the line for both teams.