The Texans insist on playing safeties in the slot, which might be a way of asking for trouble from Ladd McConkey.
Justin Jefferson looks truly unstoppable in a game where the Vikings need points and the Lions probably can't cover.
Michael Pittman could be a challenging cover for the Giants' shorter and light cornerbacks.
Ever since Marshon Lattimore switched teams, Washington's Week 15 matchup with New Orleans became a good matchup for Terry McLaurin.
The Buccaneers need to get the ball to Mike Evans, and it's not obvious what the Giants defense can do to stop it.
The Ravens might want to shadow George Pickens with Marlon Humphrey, because the other Ravens corners can't cover Pickens.
With Tua Tagovailoa back in the lineup Jaylen Waddle should get rolling against Arizona, and the same is true of Tyreek Hill if he plays through his foot injury.
Drake London's breakout should continue against a Seattle secondary that might be without its two starting boundary corners.
The showdown between Detroit and Dallas could set up a punch-for-punch heavyweight contest where CeeDee Lamb and Amon-Ra St. Brown both go off.
Dan Marcus focuses on IDPs worthy of a Week 6 pickup, including JD Bertrand, who played 73 percent of defensive snaps in Week 5 and logged five tackles, which should continue if Troy Andersen remains out.
Michael Pittman got back on track in Week 4 and should keep it rolling in Week 5, as neither the Jags nor Colts have viable coverage personnel.
George Pickens should get going against an Indianapolis defense with questionable boundary personnel
If Patrick Surtain shadows Mike Evans on the boundary then it could create a target funnel to Chris Godwin in the slot.
Amon-Ra St. Brown will likely torch a thin Buccaneers secondary playing without its star enforcer in Antoine Winfield.
There's a lot to keep track of as the Eagles face the Packers, but the headlining stories might be star free agent RB pickups Saquon Barkley and Josh Jacobs.
Mike Evans has to slow down eventually, but probably not against Washington's undersized boundary corners.
Facing a tough defense with the bull's eye on him, Sunday's showdown with Buffalo will help clarify just how good Rashee Rice can be.
The Steelers might assign Joey Porter to Stefon Diggs, but if so the decision might backfire against Pittsburgh.