Terry McLaurin should stay hot against a Titans defense starting its third- and fourth-string corners on the boundary.
The Buccaneers need to get the ball to Mike Evans, and it's not obvious what the Giants defense can do to stop it.
Deebo Samuel could go nuts as the desperate 49ers take aim at a weak Tampa Bay corner rotation.
Justin Jefferson will almost certainly have a big game Sunday, and the Colts pass defense is weak enough for Jordan Addison to get rolling in the same game.
With Tua Tagovailoa back in the lineup Jaylen Waddle should get rolling against Arizona, and the same is true of Tyreek Hill if he plays through his foot injury.
Drake London's breakout should continue against a Seattle secondary that might be without its two starting boundary corners.
The showdown between Detroit and Dallas could set up a punch-for-punch heavyweight contest where CeeDee Lamb and Amon-Ra St. Brown both go off.
Michael Pittman got back on track in Week 4 and should keep it rolling in Week 5, as neither the Jags nor Colts have viable coverage personnel.
George Pickens should get going against an Indianapolis defense with questionable boundary personnel
If Patrick Surtain shadows Mike Evans on the boundary then it could create a target funnel to Chris Godwin in the slot.
Amon-Ra St. Brown will likely torch a thin Buccaneers secondary playing without its star enforcer in Antoine Winfield.
RW's Jerry Donabedian has high hopes for key players from the Giants-Commanders game, figuring that poor defensive play combined with large workloads will lead to strong fantasy scores.
Mike Evans has to slow down eventually, but probably not against Washington's undersized boundary corners.
Our NFL Win Totals series continues with Jim Coventry's breakdown of the Washington Commanders. Can they hit the over with a new head coach and a rookie quarterback?
Juan Carlos Blanco breaks down the latest on the busy NFL injury landscape as of Sunday morning as fantasy championships get ready to be decided throughout the day.
Trevor Lawrence finally suffered an injury he can't play through, with the Jaguars officially ruling him out for Week 17.
James Cook struggled against the Chargers on Saturday, but he dominated Buffalo's backfield snaps and touches to an extent previously unseen this season.
CeeDee Lamb has been a menace from the slot, where Washington lacks the coverage personnel to defend itself.