Michael Pittman could be a challenging cover for the Giants' shorter and light cornerbacks.
Michael Penix is unproven, but the quarterback change gives new hope to Falcons pass catchers like Drake London.
Now that he's off the injury report, Mike Evans should be set up for a strong game against Las Vegas.
There's a chance DJ Moore maintains his momentum against a Detroit secondary without Carlton Davis on Thursday.
The Buccaneers need to get the ball to Mike Evans, and it's not obvious what the Giants defense can do to stop it.
Deebo Samuel could go nuts as the desperate 49ers take aim at a weak Tampa Bay corner rotation.
Justin Jefferson will almost certainly have a big game Sunday, and the Colts pass defense is weak enough for Jordan Addison to get rolling in the same game.
With Tua Tagovailoa back in the lineup Jaylen Waddle should get rolling against Arizona, and the same is true of Tyreek Hill if he plays through his foot injury.
Nick Chubb didn't have big numbers in his 2024 debut, but his role was encouraging until the Browns fell behind by multiple scores in the second half. RW's Jerry Donabedian has the full breakdown for Week 7.
Drake London's breakout should continue against a Seattle secondary that might be without its two starting boundary corners.
The showdown between Detroit and Dallas could set up a punch-for-punch heavyweight contest where CeeDee Lamb and Amon-Ra St. Brown both go off.
Michael Pittman got back on track in Week 4 and should keep it rolling in Week 5, as neither the Jags nor Colts have viable coverage personnel.
If Patrick Surtain shadows Mike Evans on the boundary then it could create a target funnel to Chris Godwin in the slot.
Mike Evans has to slow down eventually, but probably not against Washington's undersized boundary corners.
Nico Collins could see an enormous target share with the Texans managing multiple wideout injuries.
CeeDee Lamb could have one of his biggest games playing against a Lions defense that's tougher against the run than the pass.
DK Metcalf could pose a major big-play threat to Tennessee's injury-challenged corner rotation.
If New England prioritizes defending Travis Kelce then the Pats might not have leftover personnel to cover Rashee Rice.