Trevor Lawrence finally suffered an injury he can't play through, with the Jaguars officially ruling him out for Week 17.
CeeDee Lamb could have one of his biggest games playing against a Lions defense that's tougher against the run than the pass.
DK Metcalf could pose a major big-play threat to Tennessee's injury-challenged corner rotation.
Already thin at wide receiver, the Saints can only hope Chris Olave gains clearance from an independent neurologist Friday night or Saturday.
The Saints are tougher on the boundary than in the slot, which should provoke a big game from Amon-Ra St. Brown.
Michael Rathburn delivers NFL Betting Odds, Picks & Predictions for Week 12, Thanksgiving Day Football: Washington Commanders vs. Dallas Cowboys.
Rhamondre Stevenson is the centerpiece of a broken offense, and this should be one of his better weeks thanks to Sunday's matchup with another last-place team.
CeeDee Lamb has been a menace from the slot, where Washington lacks the coverage personnel to defend itself.
Jameson Williams hadn't done much with increased playing time the past two weeks before catching a TD late in the fourth quarter against Chicago this past Sunday. Is there still hope?
DeAndre Hopkins should be able to get rolling against a struggling and injured Tampa Bay corner rotation.
The Jets aren't an easy matchup for Keenan Allen, but the Chargers passing game has no other viable route for production in Week 9.
Nico Collins and Tank Dell should come roaring out of the bye week against a battered and weak Carolina secondary.
The Vikings face a simple reality Sunday: either Jordan Addison has a strong game, or the Minnesota passing game falls apart.
The Dolphins are looking to bring a shootout to the Bills, but Stefon Diggs is prepared to shoot back against Miami's questionable pass defense.
Christian Kirk should maintain momentum against a Houston defense without two of its top three corners, including their slot defender.
Drake London is due for a bounce-back after no catches in Week 1, but Jaire Alexander could deny it anyway.