Best Bills vs Texans Player Prop Bet Picks for Thursday Night Football Week 12

The Week 12 Thursday Night Football Game brings us a battle between two AFC contenders, the Buffalo Bills and Houston Texans. With C.J. Stroud out, the latest NFL Week 12 odds list the Bills as six-point favorites in this one. 

If you're looking to spice up this matchup with some NFL Week 12 player props, I've got you covered. Just make sure to use an offer like the bet365 bonus code to make the most of your picks. 

Best BetMGM Bills vs Texans Prop Bets: Week 12

BetMGM Sportsbook provides all odds in this section. Use a BetMGM bonus code to maximize your player props. 

Nico Collins – Receiving Yards: OVER 73.5 (-115) 

Nico Collins has been cooking since Davis Mills took over for Stroud midway through Week 9. Collins has seen double-digit targets in the three games since then, averaging 12.0 per game in that span. He's turned that into big-time production, eclipsing 74 yards in all three games while averaging 101.0 per game in that time. Houston is likely to be in catch-up mode for most of the game, as six-point underdogs, so I expect the Texans' alpha to see plenty of opportunities. It may not be pretty, as Buffalo is the league's sixth-best passing defense in EPA, but Collins should clear 74 yards when all is said and done. 

• ⭐️ Best Updated Odds (5 p.m. ET): O/U 66.5 (-115) – BetMGM

Best FanDuel Bills vs Texans Prop Bets: Week 12

FanDuel Sportsbook provides all odds in this section. Use a FanDuel Sportsbook promo to maximize your player props. 

James Cook – Receiving Yards: OVER 14.5 (-114) 

The Bills clearly need more capable receivers. The emergence of Tyrell Shavers and the return of Gabe Davis are fun stories, but I think increasing James Cook's receiving workload is Buffalo's best shot at solving that problem. It seems like Joe Brady agrees. After averaging 1.9 targets per game over his first eight games, Cook is averaging 4.0 targets per game over his last two. He's been incredibly efficient with those opportunities, averaging 45.0 receiving yards per outing – way up from the 12.5 he was putting up over his first eight games. Cook might struggle to produce on the ground against the league's fourth-best run defense in EPA, but I think Buffalo will look to get him going as a pass-catcher again in Week 12. 

• ⭐️ Best Updated Odds (5 p.m. ET): O/U 13.5 (-110) – BetMGM

Best DraftKings Bills vs Texans Prop Bets: Week 12

DraftKings Sportsbook provides all odds in this section. Use a DraftKings Sportsbook promo to maximize your player props. 

Woody Marks – Rushing Yards: OVER 63.5 (-111) 

This is a really lofty total for Woody Marks, who has only reached 64 yards once in 10 games this season. But there's a lot working in his favor here. Marks has taken control of this backfield, seeing his two best snap rates of the year (80% and 66%) over the last two weeks. That's a really valuable role against this bad of a run defense. Buffalo is the league's third-worst run defense in EPA – ahead of just the Bengals and Giants. They allow 153.0 rushing yards per game, which is the second-highest total in the league. And they're trending in the wrong direction, giving up 174 yards to De'Von Achane in Week 10 and 157 rushing yards to Rachaad White and Sean Tucker in Week 11. Getting Marks going on the ground is Houston's best bet at keeping pace with Buffalo, so I think they'll feed the rookie in Week 12. 

• ⭐️ Best Updated Odds (5 p.m. ET): O/U 61.5 (-112) – FanDuel

Maximize Week 12 Props With OddsJam

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2025 Primetime Player Prop Bet Record 

Each week, I'll post my updated, season-long record for these prop bet picks pieces. Here's my current record (as of Week 12): 

• 38-31 (55.0%)

Where to Bet on Week 12 TNF Props

Below, I've provided a list of the top sportsbooks that offer anytime touchdown betting markets. I've also provided the sign-up bonus at each book, so you can make the most of your prop bets.