Real Madrid need three points to keep their title hopes alive, while Celta Vigo are likely to rest starters ahead of the Europa League final, which means Cristiano Ronaldo could have a huge game Wednesday.
David Villa is likely to get plenty of fantasy captain consideration this week because he plays twice, but Adam Zdroik has a few other players who could pay off even more.
The Chicago Fire are one of 10 teams that will play twice in the upcoming round of MLS matches, which helps move Nemanja Nikolic high up the weekly rankings.
Arsenal have a big hill to climb if they want to finish in the top four, so they'll be relying heavily on Alexis Sanchez to make an impact Tuesday against Sunderland.
Nicolas Lodeiro has arguably been the best fantasy performer this season, and JD Bazzo likes him again at Chicago on Saturday.
Tottenham can clinch a second-place finish with a win Sunday against Manchester United, and fantasy owners will be looking for Harry Kane to do the damage.
Arsenal will look to keep their top-four hopes alive Saturday at Stoke City, and they'll likely need a big performance from Alexis Sanchez.
Andrew Laird and Mike Gottlieb preview the upcoming weekend of Premier League matches, including how to deal with teams that have nothing to play for and how strongly teams fighting relegation should be considered for fantasy rosters.
Swansea City continue to fight off relegation, and while an away match to Sunderland can be tricky, Kevin Swanson is still expecting Gylfi Sigurdsson to come up big.
Andrew Laird and Schuyler Redpath break down the upcoming weekend of MLS matches, including which midfielders should be passed over in favor of Lee Nguyen against RSL and how to attack Sunday's three-game slate that includes a number of the league's best
Eden Hazard could be a popular fantasy option Friday, as Chelsea look to clinch the Premier League title against West Brom at The Hawthorns.
Chelsea play twice in the upcoming gameweek, and while there could be rotation if they wrap up the title Friday against West Brom, Diego Costa still makes for a strong captain option, according to Adam Zdroik.
Arsenal continue to fight for a Champions League spot, and they'll need Alexis Sanchez to come up big Saturday at Stoke City.
Ten teams will play twice in the upcoming gameweek, and with Man City still fighting for a top-four spot, our FPL experts are high on Kevin De Bruyne.
Many fantasy managers will be focusing on players with two games this week for their fantasy captain, but Adam Zdroik reminds us not to forget about single-game players like Fanendo Adi.
The Crew will play two games this week, which helps move midfielder Justin Meram up our MLS experts' weekly positional rankings.
Real Madrid are slight underdogs this week, but will fantasy owners be bold enough to fade Cristiano Ronaldo?
While plenty of fantasy managers are likely to focus on the two sides that need to make up deficits, Andrew Laird says don't forget about why they are behind.