Atletico Madrid have to make up a big three-goal deficit, and they'll be looking to Antoine Griezmann to lead the comeback.
Chelsea will get very close to clinching the Premier League title with three points Monday against Middlesbrough, and they're likely to rely heavily on Eden Hazard to get there.
Sacha Kljestan's price isn't nearly as high as it's been in the past, and JD Bazzo thinks the Red Bulls midfielder will be a great value Saturday against the Union.
Edin Dzeko has six goals and two assists in his last seven Serie A matches, and he'll look to add to his totals Sunday against AC Milan at the San Siro.
With Manchester United prioritizing the Europa League over their domestic matches, Paul Pogba may not get an opportunity to shine against Arsenal.
Gylfi Sigurdsson ended a 10-match goalless drought last weekend against Manchester United, and he'll now try to find the back of the net against Everton at the Liberty Stadium.
Andrew Laird, Schuyler Redpath and JD Bazzo preview the upcoming weekend of MLS matches, including whether the Red Bulls will bounce back after losing to Sporting KC on Wednesday and if this is an appropriate week to fade Sebastian Giovinco.
Andrew Laird and Mike Gottlieb preview Gameweek 36 of the Premier League, which appears to include a number of terrible games, but could they actually have a ton of goals?
Jamie Vardy has scored seven goals in his last nine games, and no one on Saturday's slate has better anytime goal-scoring odds.
Spurs need to keep winning in order to stay within striking distance of Chelsea for the Premier League title, and they'll look for Harry Kane to make an impact Friday against West Ham.
No one has taken more shots, created more chances or sent in more crosses than Gylfi Sigurdsson among the players on Saturday's five-game slate.
Arsenal play twice in Gameweek 36, which means plenty of fantasy managers are likely to give the captain's armband to Alexis Sanchez, but Adam Zdroik has a different player at the top of his rankings.
Arsenal and Southampton both play twice in Gameweek 36, but Mesut Ozil struggled to move near the top of the weekly midfielder rankings.
Sebastian Giovinco is likely to be the most-captained player in Round 10, but Adam Zdroik explains why Jimmy Medranda could be the sneaky differential.
Four teams play twice in Round 10, and with Toronto FC among them, Sebastian Giovinco easily takes a top spot in this week's positional rankings.
With not many goals expected to be scored during this week's matches, solid peripheral players like Casemiro could be very helpful to fantasy managers.
While the matchup against Atletico Madrid is far from easy, fading Cristiano Ronaldo could be detrimental during this week's two-game Champions League slate.
Kylian Mbappe has been almost unstoppable of late, but he'll now have to face off against arguably the best defensive team in the world.