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Cardinals vs Jaguars Odds, Lines, Spreads & Totals 2025

Jaguars
25.0 Pts
Cardinals
22.5 Pts
Sunday November 23, 2025 at 4:05 PM ET
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JAX
Jaguars Injury Report
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ARI
Cardinals Injury Report
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JAX
Jaguars Lineup
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ARI
Cardinals Lineup
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JAX
Jaguars News
#2 ROLB
Yasir Abdullah: Won't play against Arizona
Nov 21st
Abdullah (finger) has been ruled out for Sunday's game against the Cardinals, Michael DiRocco of ESPN.com reports.
#1 RT
Anton Harrison: Ruled out for Week 12
Nov 21st
Harrison (knee) has been ruled out for Sunday's game against the Cardinals, Michael DiRocco of ESPN.com reports.
#1 SCB
Jourdan Lewis: Questionable against Arizona
Nov 21st
Lewis (neck) is questionable for Sunday's game against Cardinals, Michael DiRocco of ESPN.com reports.
#1 LCB
Jarrian Jones: Questionable for Week 12
Nov 21st
Jones (quadriceps) is questionable for Sunday's game against the Cardinals, Michael DiRocco of ESPN.com reports.
#1 RCB
Greg Newsome: Good to go Week 12
Nov 21st
Newsome (ankle) does not carry an injury designation into Sunday's game against the Cardinals.
#1 RDE
Travon Walker: Out for Week 12
Nov 21st
Walker (knee) has been ruled out for Sunday's game against the Cardinals, Michael DiRocco of ESPN.com reports.
#2 RB
Bhayshul Tuten: Cleared for Week 12, as is Etienne
Nov 21st
Tuten (ankle) doesn't have an injury designation for Sunday's game against the Cardinals, Michael DiRocco of ESPN.com reports.
#4 TE
Brenton Strange: Questionable, but still on IR
Nov 21st
Strange (hip) is listed as questionable for Sunday's game in Arizona, Michael DiRocco of ESPN.com reports.
#1 RB
Travis Etienne: Cleared after limited practices
Nov 21st
Etienne (shoulder) doesn't have an injury designation for Sunday's game against the Cardinals, Michael DiRocco of ESPN.com reports.
#1 TE
Hunter Long: Won't play Sunday
Nov 21st
Long (hip/knee) has been ruled out for Sunday's game at Arizona, Michael DiRocco of ESPN.com reports.
#1 WR
Brian Thomas: Won't play Sunday
Nov 21st
Thomas (ankle) has been ruled out for Sunday's game against the Cardinals.
#1 FS
Andrew Wingard: Five tackles in easy victory
Nov 18th
Wingard recorded five tackles (three solo) with one pass defensed in Sunday's 35-6 win over the Chargers.
#1 SS
Antonio Johnson: Continues to fill in for Murray
Nov 18th
Johnson recorded two tackles (one solo), one pass defensed and one interception in Sunday's 35-6 win over the Chargers.
#5 WR
Dyami Brown: Non-factor against Chargers
Nov 18th
Brown failed to secure his only target in Sunday's 35-6 win over the Chargers.
#1 LOLB
Foyesade Oluokun: Logs five stops vs. Bolts
Nov 17th
Oluokun recorded five total tackles (three solo) and two passes defensed in Sunday's 35-6 win over the Chargers.
#3 TE
Johnny Mundt: Notches two receptions
Nov 17th
Mundt caught two of three targets for 25 yards during Sunday's 35-6 win against the Chargers.
#2 TE
Quintin Morris: Catches first pass of 2025
Nov 17th
Morris secured one of three targets for 11 yards during Sunday's 35-6 win against the Chargers.
#3 WR
Parker Washington: Targeted twice in blowout win
Nov 17th
Washington caught both his targets for 20 yards during Sunday's 35-6 win against the Chargers.
#3 RB
LeQuint Allen: Garners eight garbage-time carries
Nov 17th
Allen rushed eight times for 36 yards and returned two kickoffs for 55 yards during Sunday's 35-6 win against the Chargers.
#1 K
Cam Little: Makes five PATs in win
Nov 16th
Little did not attempt a field goal and went 5-for-5 on PATs in Sunday's 35-6 win over the Chargers.
#1 QB
Trevor Lawrence: Posts two total TDs in win
Nov 16th
Lawrence completed 14 of 22 passes for 153 yards with a touchdown and an interception while rushing five times for nine yards and another score in the Jaguars' 35-6 win over the Chargers on Sunday.
#2 WR
Jakobi Meyers: Leads Jags wideouts in Week 11 win
Nov 16th
Meyers caught five passes (on six targets) for 64 yards during the Jaguars' 35-6 win over the Chargers on Sunday.
#4 WR
Tim Patrick: Hauls in one-yard TD pass
Nov 16th
Patrick finished Sunday's 35-6 win over the Chargers with three catches (on four targets) for 20 yards and a touchdown.
#4 RB
Cody Schrader: Healthy scratch
Nov 16th
Scrader (coach's decision) is inactive for Sunday's game against the Chargers.
#2 LCB
Travis Hunter: Set to remain two-way player in '26
Nov 16th
The Jaguars plan to continue utilizing Hunter (knee) as their top wide receiver and as a matchup cornerback in 2026, Ian Rapoport of NFL Network reports.
#1 LG
Ezra Cleveland: Set to return Week 11
Nov 14th
Cleveland (knee) does not have an injury designation for Sunday's game against the Chargers.
#1 ROLB
Dennis Gardeck: Good to go Sunday
Nov 14th
Gardeck (chest) has no injury designation ahead of Sunday's matchup against the Chargers.
#1 MLB
Devin Lloyd: Racks up eight stops in Week 10
Nov 11th
Lloyd finished Sunday's loss to the Texans with eight tackles (two solo).
#6 WR
Austin Trammell: Secures first catches of 2025
Nov 10th
Trammell caught two of three targets for 33 yards during Sunday's 36-29 loss to the Texans.
ARI
Cardinals News
#1 RG
Will Hernandez: Questionable for Week 12
Nov 21st
Hernandez (ankle) is questionable for Sunday's game against the Jaguars, Bo Brack of GoPHNX.com reports.
#2 LT
Kelvin Beachum: Questionable for Week 12
Nov 21st
Beachum (groin) is questionable for Sunday's game against the Jaguars, Bo Brack of GoPHNX.com reports.
#2 RT
Kelvin Beachum: Questionable for Week 12
Nov 21st
Beachum (groin) is questionable for Sunday's game against the Jaguars, Bo Brack of GoPHNX.com reports.
#2 SS
Dadrion Taylor-Demerson: Ruled out
Nov 21st
Taylor-Demerson (ankle) has been ruled out for Sunday's game against the Jaguars, Bo Brack of GoPHNX.com reports.
#5 RT
Jonah Williams: Heads to IR with shoulder injury
Nov 21st
The Cardinals placed Williams (shoulder) on injured reserve Friday.
#1 SCB
Garrett Williams: Draws questionable tag for Week 12
Nov 21st
Williams (ankle) is listed as questionable for Sunday's game against the Jaguars, Bo Brack of GoPHNX.com reports.
#1 RDE
Darius Robinson: Listed as questionable for Week 12
Nov 21st
Robinson (groin) is listed as questionable for Sunday's game against Jacksonville, Bo Brack of GoPHNX.com reports.
#1 LCB
Will Johnson: Questionable for Week 12
Nov 21st
Johnson (back) is listed as questionable for Sunday's game against the Jaguars, Bo Brack of GoPHNX.com reports.
#1 RB
Bam Knight: Cleared to play, unlike Benson
Nov 21st
Knight (ankle) doesn't have an injury designation for Sunday's game against the Jaguars, Bo Brack of GoPHNX.com reports.
#5 RB
Trey Benson: Won't return this week
Nov 21st
Benson (knee) has been ruled out for Sunday's game against Jacksonville, Bo Brack of GoPHNX.com reports.
#4 RB
Jermar Jefferson: Signed to active roster
Nov 21st
The Cardinals signed Jefferson to their active roster Friday, Darren Urban of the Cardinals' official site reports.
#2 SLB
Baron Browning: Ruled out for Week 12
Nov 21st
Browning (concussion) won't play Sunday against the Jaguars, Bo Brack of PHNX Sports reports.
#2 WR
Michael Wilson: Set for another week as WR1
Nov 19th
Wilson is positioned as the No. 1 wideout for Sunday's game against the Jaguars with Marvin Harrison (appendix) ruled out again, Theo Mackie of The Arizona Republic reports.
#2 RB
Emari Demercado: Officially out for Week 12
Nov 19th
Cardinals coach Jonathan Gannon said Wednesday that Demercado (ankle) has been ruled out for Sunday's game against the Jaguars, Theo Mackie of The Arizona Republic reports.
#1 WR
Marvin Harrison: Ruled out for Week 12
Nov 19th
Cardinals head coach Jonathan Gannon said Wednesday that Harrison (appendix) is ruled out for Sunday's contest against the Jaguars, Theo Mackie of The Arizona Republic reports.
#2 RCB
Denzel Burke: Limited impact in loss
Nov 18th
Burke recorded two tackles (one solo) with one pass defensed in Sunday's 41-22 loss to the 49ers.
#1 WLB
Akeem Davis-Gaither: Makes four tackles
Nov 18th
Davis-Gaither recorded four tackles (one solo) in Sunday's 41-22 loss to the 49ers.
#4 WR
Xavier Weaver: Minimal production against 49ers
Nov 18th
Weaver caught two of three targets for 15 yards in Sunday's 41-22 loss to the 49ers.
#2 TE
Elijah Higgins: Two grabs in loss
Nov 18th
Higgins caught two of three targets for 11 yards in Sunday's 41-22 loss to the 49ers.
#1 FS
Budda Baker: Posts eight stops vs. San Fran
Nov 17th
Baker logged eight tackles (three solo) during the Cardinals' 41-22 loss to the 49ers on Sunday.
#1 MLB
Cody Simon: Leads Arizona with 12 stops
Nov 17th
Simon posted 12 tackles (four solo) during the Cardinals' 41-22 loss to the 49ers on Sunday.
#3 WR
Greg Dortch: Records six catches, TD in Week 11
Nov 17th
Dortch hauled in all six of his targets for 66 yards and one touchdown during Sunday's 41-22 defeat to the 49ers.
#3 RB
Michael Carter: Role increases Sunday
Nov 17th
Carter had two carries for six yards and gathered in five of seven targets for 22 yards during Sunday's 41-22 loss to the 49ers.
#1 K
Chad Ryland: Converts one field goal in loss
Nov 16th
Ryland went 1-for-2 on field-goal tries and made his only PAT in Sunday's 41-22 loss to the 49ers.
#1 TE
Trey McBride: Extends TD streak to five games
Nov 16th
McBride finished with 10 receptions on 11 targets for 115 yards and a touchdown in Sunday's 41-22 loss to the 49ers.
#1 QB
Jacoby Brissett: Sets NFL record for completions
Nov 16th
Brissett completed 47 of 57 passes for 452 yards, two touchdowns and two interceptions and rushed twice for minus-2 yards during Sunday's 41-22 loss to the 49ers.
#3 SLB
BJ Ojulari: Officially active for Week 11
Nov 16th
Ojulari (knee) is active for Sunday's game against the 49ers, Darren Urban of the Cardinals' official site reports.
#1 DT2
Walter Nolen: Good to go Week 11
Nov 16th
Nolen (knee) is active for Sunday's game against the 49ers, Darren Urban of the Cardinals' official site reports.
#2 MLB
Mack Wilson: Lands on injured reserve
Nov 15th
The Cardinals placed Wilson (ribs) on injured reserve Saturday, Darren Urban of the team's official site reports.
#2 LG
Hayden Conner: Won't be activated off IR
Nov 14th
Conner (knee) has been ruled out for Sunday's game against the 49ers, Zach Gershman of the Cardinals' official site reports.
#1 LG
Evan Brown: Cleared to play Week 11
Nov 14th
Brown (foot) does not have an injury designation for Sunday's game against the 49ers, Zach Gershman of the Cardinals' official site reports.
#1 RCB
Max Melton: Looking good for Sunday
Nov 14th
Melton (concussion) does not carry an injury designation ahead of Sunday's game versus the 49ers, Zach Gershman of the Cardinals' official site reports.
#5 WR
Andre Baccellia: Signed to Arizona's active roster
Nov 12th
The Cardinals signed Baccellia from the practice squad to the active roster Wednesday.
#7 WR
Simi Fehoko: Placed on injured reserve
Nov 12th
Fehoko (wrist) was placed on injured reserve Wednesday, Darren Urban of the Cardinals' official site reports.
#6 WR
Zay Jones: Officially shifts to IR
Nov 12th
The Cardinals placed Jones (Achilles) on injured reserve Wednesday.
#1 LDE
Josh Sweat: Takes down QB in Week 10 loss
Nov 11th
Sweat recorded one tackle (which was a full sack), one forced fumble and one recovered fumble in Sunday's loss to Seattle.
#2 FS
Kitan Crawford: Green light to play Week 10
Nov 9th
Crawford (ankle) is active for Sunday's game against Seattle.
#3 QB
Kyler Murray: Future in Arizona in limbo
Nov 9th
Murray, who was placed on injured reserve Wednesday due to a mid-foot sprain, is not expected to start again if he returns this season, "absent injury to Jacoby Brissett," Ian Rapoport of NFL Network reports.