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Saints vs 49ers Odds, Lines, Spreads & Totals 2025

49ers
21.8 Pts
Saints
18.8 Pts
Sunday September 14, 2025 at 1:00 PM ET
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49ers Injury Report
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Saints Injury Report
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SF
49ers Lineup
Inactives
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Saints Lineup
Inactives
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SF
49ers News
#1 QB
Brock Purdy: Could miss 2-to-5 weeks
Sep 11th
Purdy, whom head coach Kyle Shanahan has called a "longshot" to play Sunday against the Saints, could miss 2-to-5 weeks with a turf toe variant, Ian Rapoport of NFL Network reports.
#2 LDE
Yetur Gross-Matos: Misses practice Wednesday
Sep 10th
Gross-Matos (knee) did not participate at practice Wednesday, Jennifer Lee Chan of NBC Sports Bay Area reports.
#5 WR
Jordan Watkins: Limited to open week
Sep 10th
Watkins (ankle) was a limited participant at practice Wednesday, Jennifer Lee Chan of NBC Sports Bay Area reports.
#4 RB
Jordan James: Limited at practice
Sep 10th
James (finger) was a limited participant at practice Wednesday, Jennifer Lee Chan of NBC Sports Bay Area reports.
#2 QB
Mac Jones: Likely starting Week 2
Sep 10th
San Francisco coach Kyle Shanahan suggested Jones is likely to start Sunday's game at New Orleans in place of Brock Purdy (toe, shoulder), Nick Wagoner of ESPN.com reports.
#1 WR
Jauan Jennings: DNP on Wednesday
Sep 10th
Jennings (shoulder) won't take part in Wednesday's practice, Cam Inman of The San Jose Mercury News reports.
#2 TE
Luke Farrell: Increased reps on tap
Sep 10th
Farrell and Jake Tonges are in line for increased snaps, beginning Sunday versus the Saints, with starting tight end George Kittle (hamstring) having been placed on IR and out a minimum of four games, Dianna Russini, Vic Tafur and Matt Barrows of The Athletic report.
#3 TE
Jake Tonges: Opportunity knocks
Sep 10th
Tonges and Luke Farrell are in line for more snaps at tight end, beginning Sunday versus the Saints, with George Kittle (hamstring) on IR and set to miss at least four games, Dianna Russini, Vic Tafur and Matt Barrows of The Athletic report.
#1 K
Eddy Pineiro: Replacing Moody in San Francisco
Sep 9th
Pineiro agreed to a one-year contract with the 49ers on Tuesday, Adam Schefter of ESPN reports.
#1 TE
George Kittle: Move to IR official
Sep 9th
The 49ers placed Kittle (hamstring) on injured reserve Tuesday.
#1 RDE
Nick Bosa: Strip sack in win
Sep 8th
Bosa recorded six solo tackles, including 1.0 sacks, while also adding a forced fumble and a fumble recovery in Sunday's 17-13 win over the Seahawks.
#1 FB
Kyle Juszczyk: Gains 32 yards Sunday
Sep 8th
Juszczyk recorded two receptions for 32 yards on two targets in Sunday's 17-13 win over Seattle.
#4 WR
Marquez Valdes-Scantling: Plays role of decoy Sunday
Sep 8th
Valdes-Scantling logged 27 snaps on offense and did not receive a target in Sunday's 17-13 win over the Seahawks.
#6 WR
Skyy Moore: Handles return duties for SF
Sep 8th
Moore did not receive a target and returned five combined kicks for 63 yards in Sunday's 17-13 win over Seattle.
#3 RB
Isaac Guerendo: Limited to special teams
Sep 8th
Guerendo played 15 snaps on special teams and did not receive a carry in Sunday's 17-13 win over the Seahawks.
#2 RB
Brian Robinson: Gets 10 touches in SF debut
Sep 8th
Robinson rushed nine times for 33 yards and had one reception for four yards on two targets in Sunday's 17-13 win over Seattle.
#3 WR
Kendrick Bourne: Reuniting with Niners
Sep 8th
Bourne has agreed to terms Monday on a one-year contract worth up to $5 million with San Francisco, Adam Schefter of ESPN reports.
#1 MLB
Fred Warner: Plays well in Week 1
Sep 8th
Warner tallied eight total tackles (four solo), including one tackle for loss, in Sunday's 17-13 win over the Seahawks.
#1 RT
Colton McKivitz: Inks extension with San Francisco
Sep 8th
McKivitz signed a three-year, $45 million extension with the 49ers on Monday, Adam Schefter of ESPN reports.
#2 WR
Ricky Pearsall: Leads team with 108 receiving yards
Sep 7th
Pearsall brought in four of seven targets for 108 yards in Sunday's 17-13 win over Seattle.
#1 RB
Christian McCaffrey: Racks up 142 yards from scrimmage
Sep 7th
McCaffrey (calf) handled 22 carries for 69 yards and nine receptions for 73 yards on 10 targets in Sunday's 17-13 win over the Seahawks.
#1 FS
Marques Sigle: Gets starting nod Week 1
Sep 7th
Sigle will be the 49ers' starting safety against the Seahawks on Sunday, Matt Maiocco of NBC Sports Bay Area reports.
#1 RG
Dominick Puni: Ready to face Seahawks
Sep 5th
Puni (knee) does not have an injury designation ahead of Sunday's game against the Seahawks, Michael-Shawn Dugar of The Athletic reports.
#1 LG
Ben Bartch: Full practice Wednesday
Sep 3rd
Bartch (elbow) was a full participant at the 49ers' practice Wednesday, Cam Inman of The San Jose Mercury News reports.
#2 RDE
Sam Okuayinonu: Logs full practice Wednesday
Sep 3rd
Okuayinonu (shoulder) was a full participant in Wednesday's practice, Cam Inman of The San Jose Mercury News reports.
#2 DT2
CJ West: Logs full practice Wednesday
Sep 3rd
West (knee) was a full participant in Wednesday's practice, Cam Inman of The San Jose Mercury News reports.
#1 SCB
Upton Stout: Recovered from calf injury
Sep 3rd
Stout (calf) was a full participant in Wednesday's practice, Cam Inman of The San Jose Mercury News reports.
#1 LDE
Mykel Williams: Full participant in practice
Sep 3rd
Williams (knee) practiced in full Wednesday, Cam Inman of The San Jose Mercury News reports.
#1 RCB
Deommodore Lenoir: Recovered from hip injury
Sep 3rd
Lenoir (hip) was not listed on the 49er's injury report Wednesday, Cam Inman of The San Jose Mercury News reports.
NO
Saints News
#1 RT
Taliese Fuaga: Still dealing with knee injury
Sep 10th
Fuaga (knee) did not participate at practice Wednesday, John Hendrix of AthlonSports.com reports.
#1 LG
Trevor Penning: Still nursing toe injury
Sep 10th
Penning (toe) did not participate at practice Wednesday, John Hendrix of AthlonSports.com reports.
#1 SLB
Chase Young: Opens week with DNP
Sep 10th
Young (calf) did not participate in Wednesday's practice, John Hendrix of AthlonSports.com reports.
#2 SS
Jordan Howden: Past oblique injury
Sep 10th
Howden (oblique) was a full participant in Wednesday's practice, John Hendrix of AthlonSports.com reports.
#2 FS
Julian Blackmon: Will undergo surgery
Sep 10th
Blackmon will undergo surgery to address the shoulder injury he suffered during Sunday's 20-13 loss versus the Cardinals, Matthew Paras of The New Orleans Times-Picayune reports.
#1 LDE
Cameron Jordan: Posts 1.5 sacks in opener
Sep 9th
Jordan tallied three tackles, including 1.5 sacks, along with a defensed pass Sunday in a Week 1 loss to the Cardinals.
#1 LCB
Kool-Aid McKinstry: Records seven stops Week 1
Sep 9th
McKinstry posted seven tackles (five solo) and a defensed pass in a loss to Arizona on Sunday.
#1 RCB
Alontae Taylor: Gets to QB in Week 1
Sep 9th
Taylor recording two tackles, including 1.0 sacks, in a loss to the Cardinals on Sunday.
#2 TE
Jack Stoll: Signed to Saints' 53-man roster
Sep 9th
The Saints signed Stoll from the practice squad to the active roster Tuesday.
#1 LILB
Demario Davis: Tallies nine stops Week 1
Sep 8th
Davis recorded nine tackles (seven solo) during Sunday's 20-13 loss to the Cardinals.
#3 RB
Devin Neal: Gets two touches in season opener
Sep 8th
Neal recorded two carries for nine yards during Sunday's 20-13 loss against the Cardinals.
#2 RB
Kendre Miller: Totes the rock five times Week 1
Sep 8th
Miller compiled five rushes for 24 yards during Sunday's 20-13 defeat versus the Cardinals.
#1 WLB
Carl Granderson: Gets to QB twice in loss
Sep 8th
Granderson recorded six total tackles (five solo), including 1.5 sacks, while also adding two passes defensed in Sunday's 20-13 loss to Arizona.
#1 RILB
Pete Werner: Nine tackles in loss
Sep 8th
Werner recorded nine total tackles (seven solo), including 1.0 sacks, in Sunday's 20-13 loss to the Cardinals.
#4 WR
Devaughn Vele: Nabs one pass in NOLA debut
Sep 7th
Vele recorded one reception (on three targets) for 13 yards during Sunday's 20-13 defeat versus the Cardinals.
#3 WR
Brandin Cooks: Catches three passes Week 1
Sep 7th
Cooks had three receptions (on four targets) for 26 yards during Sunday's 20-13 loss versus the Cardinals.
#1 K
Blake Grupe: Makes pair of FGs in loss
Sep 7th
Grupe went 2-of-3 on field-goal attempts and converted his lone extra-point try in the Saints' 20-13 loss to the Cardinals on Sunday.
#2 WR
Rashid Shaheed: Hauls in six passes in loss
Sep 7th
Shaheed caught six of nine targets for 33 yards in Sunday's 20-13 loss to the Cardinals.
#1 TE
Juwan Johnson: Leading receiver against Cards
Sep 7th
Johnson caught eight of 11 targets for 76 yards in Sunday's 20-13 loss to the Cardinals.
#1 WR
Chris Olave: Sees big volume in loss
Sep 7th
Olave caught seven of 13 targets for 54 yards in Sunday's 20-13 loss to the Cardinals.
#1 RB
Alvin Kamara: Gets into end zone against Cards
Sep 7th
Kamara carried the ball 11 times for 45 yards and a touchdown and caught both his targets for 12 yards in Sunday's 20-13 loss to Arizona.
#1 QB
Spencer Rattler: Does little on big volume
Sep 7th
Rattler completed 27 of 46 passes for 214 yards in Sunday's 20-13 loss to the Cardinals. He added 29 rushing yards on four carries.
#6 WR
Trey Palmer: Inactive for Week 1
Sep 7th
Palmer (coach's decision) is a healthy scratch for Sunday's clash against the Cardinals.
#2 NT
Khristian Boyd: Past hand injury
Sep 4th
Boyd (hand) was a full participant in Thursday's practice.
#1 LS
Zach Wood: All set for Week 1
Sep 3rd
Wood (hamstring) did not appear on the Saints' injury report Wednesday.