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49ers vs Panthers Odds, Lines, Spreads & Totals 2025

Panthers
21.0 Pts
49ers
28.5 Pts
Monday November 24, 2025 at 8:15 PM ET
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Panthers Injury Report
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49ers Injury Report
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Panthers Lineup
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49ers Lineup
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CAR
Panthers News
#1 C
Cade Mays: Won't play Week 12
Nov 22nd
May (ankle) has been ruled out for Monday's game against the 49ers, Alex Zietlow of The Charlotte Observer reports.
#1 RILB
Trevin Wallace: Will not play Monday
Nov 22nd
Wallace (shoulder) has been ruled out for Monday's game against San Francisco, Darin Gantt of the team's official website reports.
#1 LILB
Christian Rozeboom: Ruled out for Monday
Nov 22nd
Rozeboom (hip/hamstring) has been ruled out for Monday's game against San Francisco, Darin Gantt of the team's official website reports.
#1 LDE
Tershawn Wharton: Past knee injury
Nov 21st
Wharton (knee) was a full participant in Friday's practice, David Newton of ESPN.com reports.
#2 FS
Lathan Ransom: Trending up for Week 12
Nov 20th
Ransom (hand) was a full participant in practice Thursday.
#2 WR
Xavier Legette: Opens week with full practice
Nov 20th
Panthers head coach Dave Canales said that Legette (hip) was a full participant in Thursday's practice, Joe Person of The Athletic reports.
#1 RDE
Derrick Brown: No stats in win
Nov 18th
Brown did not record a stat in Sunday's 30-27 win over the Falcons.
#1 WLB
Nic Scourton: Production contunes ticking up
Nov 18th
Scourton recorded five tackles (three solo) with one tackle for loss in Sunday's 30-27 win over the Falcons.
#1 FS
Nick Scott: Makes eight tackles
Nov 18th
Scott recorded eight tackles (two solo) in Sunday's 30-27 win over the Falcons.
#2 RILB
Claudin Cherelus: Impresses in starting role
Nov 17th
Cherelus tallied 10 total tackles (two solo) and one pass defended in Sunday's 30-27 overtime win over the Falcons.
#1 SS
Tre'von Moehrig: Double-digit stops in win
Nov 17th
Moehrig recorded 11 total tackles (six solo) in Sunday's 30-27 overtime win over the Falcons.
#1 TE
Ja'Tavion Sanders: Another solid outing Sunday
Nov 17th
Sanders caught all four of his targets for 22 yards in Sunday's 30-27 overtime win over the Falcons.
#2 TE
Tommy Tremble: Huge catch in OT win
Nov 17th
Tremble caught one of two targets for 54 yards in Sunday's 30-27 overtime win over the Falcons.
#3 TE
Mitchell Evans: Logs 28 yards vs. Falcons
Nov 17th
Evans caught both of his targets for 28 yards in Sunday's 30-27 overtime win over the Falcons.
#3 RB
Trevor Etienne: Gets one carry in Week 11
Nov 17th
Etienne played just four of the Panthers' 75 offensive snaps and rushed once for two yards in Sunday's 30-27 overtime win over the Falcons.
#1 K
Ryan Fitzgerald: Walks off Atlanta in overtime
Nov 16th
Fitzgerald went 3-for-3 on field-goal attempts and made his only extra-point try in Sunday's 30-27 overtime win against the Falcons.
#2 RB
Chuba Hubbard: Minimal output in reserve role
Nov 16th
Hubbard rushed four times for 21 yards and caught one of three targets for seven yards in Sunday's 30-27 overtime win over the Falcons.
#3 WR
Jalen Coker: Catches four passes vs. Falcons
Nov 16th
Coker caught all four of his targets for 52 yards in Sunday's 30-27 overtime win over the Falcons.
#1 RB
Rico Dowdle: Logs another 100-yard outing
Nov 16th
Dowdle rushed 19 times for 45 yards and caught five of seven targets for 55 yards in Sunday's 30-27 overtime win over the Falcons.
#1 WR
Tetairoa McMillan: Monster performance in Week 11
Nov 16th
McMillan caught eight of 12 targets for 130 yards and two touchdowns in Sunday's 30-27 overtime win over the Falcons.
#1 QB
Bryce Young: Career day in win
Nov 16th
Young completed 31 of 45 pass attempts for 448 yards and three touchdowns during Sunday's 30-27 overtime win over the Falcons.
#6 WR
Hunter Renfrow: Inactive again Week 11
Nov 16th
Renfrow (coach's decision) is a healthy scratch for Sunday's matchup against Atlanta, Darin Gantt of the Panthers' official site reports.
#1 RG
Chandler Zavala: Practices in full Wednesday
Nov 12th
Zavala (elbow) was a full practice participant Wednesday, Darin Gantt of the Panthers' official site reports.
#5 WR
Brycen Tremayne: Logs full practice
Nov 12th
Tremayne (hip) practiced in full Wednesday, Darin Gantt of the Panthers' official site reports.
#2 SLB
Princely Umanmielen: Looks good for Week 11
Nov 12th
Umanmielen was not on Carolina's injury report Wednesday.
SF
49ers News
#7 WR
Brandon Aiyuk: Could still play for team in 2025
Nov 23rd
The 49ers remain committed to getting Aiyuk (knee) "healthy and back on the field" in 2025, even though the team had approximately $27 million in guarantees for the 2026 season voided in his contract, Mike Garafolo of NFL Network reports.
#2 RDE
Robert Beal: Doubtful due to concussion
Nov 22nd
Beal (concussion) is listed as doubtful for Monday night's game against Carolina, Cam Inman of The San Jose Mercury News reports.
#1 SLB
Luke Gifford: Questionable for Week 12
Nov 22nd
Gifford (hip/neck) is questionable for Monday night's game against the Panthers, Cam Inman of The San Jose Mercury News reports.
#1 MLB
Tatum Bethune: Ruled out for Week 12
Nov 22nd
Bethune (ankle) has been ruled out for Monday's game against Carolina, Cam Inman of The San Jose Mercury News reports.
#1 K
Eddy Pineiro: Won't play Week 12
Nov 22nd
Pineiro (hamstring) has been ruled out for Monday's game against the Panthers, Cam Inman of The San Jose Mercury News reports.
#1 LCB
Renardo Green: Logs six tackles Sunday
Nov 18th
Green recorded six tackles (four solo) during San Francisco's win over the Cardinals on Sunday.
#1 SS
Ji'Ayir Brown: Productive in win
Nov 18th
Brown tallied seven tackles (three solo) in San Francisco's win over the Cardinals on Sunday.
#1 SCB
Upton Stout: Forces fumble in win
Nov 18th
Stout tallied seven tackles (two solo) and forced a fumble in San Francisco's win versus the Cardinals on Sunday.
#1 FS
Malik Mustapha: Snags pick in win
Nov 18th
Mustapha logged four tackles (one solo) and an interception during San Francisco's win over the Cardinals on Sunday.
#1 WLB
Dee Winters: Double-digit tackles vs. Arizona
Nov 17th
Winters posted 10 tackles (five solo) during the 49ers' 41-22 win over the Cardinals on Sunday.
#2 MLB
Curtis Robinson: Expanded role after Bethune exit
Nov 17th
Robinson totaled 12 tackles (five solo) during the 49ers' 41-22 win over the Cardinals on Sunday.
#1 RCB
Deommodore Lenoir: Picks off Brissett in Week 11 win
Nov 17th
Lenoir posted seven tackles (four solo) and two pass defenses (including an interception) during the 49ers' 41-22 win over the Cardinals on Sunday.
#8 WR
Jacob Cowing: Expected to practice following bye
Nov 17th
Coach Kyle Shanahan said Monday that Cowing's (hamstring) 21-day practice window will likely be opened following the 49ers' Week 14 bye, Matt Maiocco of NBC Sports Bay Area reports.
#2 TE
Luke Farrell: No receptions Sunday
Nov 17th
Farrell was not targeted as a receiver in Sunday's 41-22 victory over Arizona.
#5 WR
Skyy Moore: Returns kickoff 98 yards Sunday
Nov 17th
Moore was not targeted as a receiver while returning two kicks for 107 combined yards in Sunday's 41-22 win over Arizona.
#2 RB
Brian Robinson: Gains 24 yards Sunday
Nov 17th
Robinson rushed eight times for 24 yards while failing to bring in his only target in Sunday's 41-22 win over Arizona.
#3 WR
Demarcus Robinson: Nabs one reception as No. 3 WR
Nov 17th
Robinson had one reception (on two targets) for 13 yards in Sunday's 41-22 victory over the Cardinals.
#4 WR
Kendrick Bourne: Falls out of favor Sunday
Nov 17th
Bourne was not targeted as a receiver in Sunday's 41-22 win over the Cardinals.
#1 TE
George Kittle: Carries over hot play from Week 10
Nov 16th
Kittle hauled in all six of his targets for 67 yards and two touchdowns in Sunday's 41-22 rout of the Cardinals.
#1 WR
Jauan Jennings: Gains 54 yards in blowout
Nov 16th
Jennings had four receptions on six targets for 54 yards in Sunday's 41-22 win over the Cardinals.
#1 RB
Christian McCaffrey: Scores thrice in dominant win
Nov 16th
McCaffrey rushed 13 times for 81 yards and two touchdowns while bringing in five of six targets for 40 yards and a third score in Sunday's 41-22 rout of the Cardinals.
#2 WR
Ricky Pearsall: Just one catch in return
Nov 16th
Pearsall (knee) had one reception on three targets for no gain in Sunday's 41-22 win over the Cardinals.
#1 QB
Brock Purdy: Healthy stat line in return
Nov 16th
Purdy (toe) completed 19 of 26 pass attempts for 200 yards and three touchdowns while losing seven yards on his only carry in Sunday's 41-22 win over the Cardinals.
#6 WR
Jordan Watkins: Inactive against Cardinals
Nov 16th
Watkins (coach's decision) is inactive for Sunday's game against the Cardinals, Briana Jeannel of the 49ers' official site reports.
#4 RB
Jordan James: Healthy scratch
Nov 16th
James (coach's decision) is inactive for Sunday's game against the Cardinals, Briana Jeannel of the 49ers' official site reports.
#1 DT2
Alfred Collins: Will play against Arizona
Nov 14th
Collins (hip) does not carry an injury designation into Sunday's game against the Cardinals.
#2 QB
Mac Jones: Drops back to backup role
Nov 14th
Jones will return to a backup role due to teammate Brock Purdy (toe) being cleared to start Sunday's game against the Cardinals.