San Francisco 49ers vs Carolina Panthers Odds, Week 12, 2025

#1 WLB

Dee Winters: Double-digit tackles vs. Arizona

Nov 17th

Winters posted 10 tackles (five solo) during the 49ers' 41-22 win over the Cardinals on Sunday.

#2 MLB

Curtis Robinson: Expanded role after Bethune exit

Nov 17th

Robinson totaled 12 tackles (five solo) during the 49ers' 41-22 win over the Cardinals on Sunday.

#1 RCB

Deommodore Lenoir: Picks off Brissett in Week 11 win

Nov 17th

Lenoir posted seven tackles (four solo) and two pass defenses (including an interception) during the 49ers' 41-22 win over the Cardinals on Sunday.

#1 MLB

Tatum Bethune: Diagnosed with high-ankle sprain

Nov 17th

San Francisco head coach Kyle Shanahan said that Bethune suffered a right high-ankle sprain in Sunday's 41-22 win over the Cardinals and is expected to miss multiple weeks, David Lombardi of SFStandard.com reports.

#8 WR

Jacob Cowing: Expected to practice following bye

Nov 17th

Coach Kyle Shanahan said Monday that Cowing's (hamstring) 21-day practice window will likely be opened following the 49ers' Week 14 bye, Matt Maiocco of NBC Sports Bay Area reports.

#1 K

Eddy Pineiro: Viewed as week-to-week

Nov 17th

Coach Kyle Shanahan said Monday that Pineiro (hamstring) is considered week-to-week, David Lombardi of SFStandard.com reports.

#7 WR

Brandon Aiyuk: Out for Week 12, still week-to-week

Nov 17th

Coach Kyle Shanahan said Monday that Aiyuk's (knee) 21-day practice window will not be opened this week, and he remains week-to-week, Matt Barrows of The Athletic reports.

#2 TE

Luke Farrell: No receptions Sunday

Nov 17th

Farrell was not target as a receiver in Sunday's 41-22 victory over Arizona.

#5 WR

Skyy Moore: Returns kickoff 98 yards Sunday

Nov 17th

Moore was not targeted as a receiver while returning two kicks for 107 combined yards in Sunday's 41-22 win over Arizona.

#2 RB

Brian Robinson: Gains 24 yards Sunday

Nov 17th

Robinson rushed eight times for 24 yards while failing to bring in his only target in Sunday's 41-22 win over Arizona.

#3 WR

Demarcus Robinson: Nabs one reception as No. 3 WR

Nov 17th

Robinson had one reception on two targets for 13 yards in Sunday's 41-22 victory over the Cardinals.

#4 WR

Kendrick Bourne: Falls out of favor Sunday

Nov 17th

Bourne was not targeted as a receiver in Sunday's 41-22 win over the Cardinals.

#1 TE

George Kittle: Carries over hot play from Week 10

Nov 16th

Kittle hauled in all six of his targets for 67 yards and two touchdowns in Sunday's 41-22 rout of the Cardinals.

#1 WR

Jauan Jennings: Gains 54 yards in blowout

Nov 16th

Jennings had four receptions on six targets for 54 yards in Sunday's 41-22 win over the Cardinals.

#1 RB

Christian McCaffrey: Scores thrice in dominant win

Nov 16th

McCaffrey rushed 13 times for 81 yards and two touchdowns while bringing in five of six targets for 40 yards and a third score in Sunday's 41-22 rout of the Cardinals.

#2 WR

Ricky Pearsall: Just one catch in return

Nov 16th

Pearsall (knee) had one reception on three targets for no gain in Sunday's 41-22 win over the Cardinals.

#1 QB

Brock Purdy: Healthy stat line in return

Nov 16th

Purdy (toe) completed 19 of 26 pass attempts for 200 yards and three touchdowns while losing seven yards on his only carry in Sunday's 41-22 win over the Cardinals.

#2 RDE

Robert Beal: Done for day

Nov 16th

Beal suffered a concussion in the first half of Sunday's contest against Arizona, Jennifer Lee Chan of NBC Sports Bay Area reports.

#6 WR

Jordan Watkins: Inactive against Cardinals

Nov 16th

Watkins (coach's decision) is inactive for Sunday's game against the Cardinals, Briana Jeannel of the 49ers' official site reports.

#4 RB

Jordan James: Healthy scratch

Nov 16th

James (coach's decision) is inactive for Sunday's game against the Cardinals, Briana Jeannel of the 49ers' official site reports.

#1 DT2

Alfred Collins: Will play against Arizona

Nov 14th

Collins (hip) does not carry an injury designation into Sunday's game against the Cardinals.

#2 QB

Mac Jones: Drops back to backup role

Nov 14th

Jones will return to a backup role due to teammate Brock Purdy (toe) being cleared to start Sunday's game against the Cardinals.

#1 SCB

Upton Stout: Makes four stops in Week 10 loss

Nov 11th

Stout secured four tackles (one solo) against the Rams in Sunday's loss.

#1 FS

Malik Mustapha: Posts eight stops in Week 10 loss

Nov 11th

Mustapha notched eight tackles (four solo) in Sunday's loss to the Rams.

#1 SS

Ji'Ayir Brown: Notches double-digit tackles

Nov 10th

Brown recorded 10 tackles (three solo) and one pass defensed in Sunday's 42-26 loss to the Rams.

#2 LDE

Keion White: Cleared to play vs. Rams

Nov 9th

White (groin) is active for Sunday's game against the Rams, Briana Jeannel of the 49ers' official site reports.

#1 LG

Ben Bartch: Officially returning in Week 10

Nov 9th

Bartch (ankle) is active for Sunday's battle against the Rams, Briana Jeannel of the 49ers' official site reports.

#1 LDT

Kalia Davis: Will play Week 10

Nov 9th

Davis (ankle) is active for Sunday's game against the Rams, Briana Jeannel of the 49ers' official site reports.

#5 RDE

Mykel Williams: Sent to injured reserve

Nov 8th

The 49ers placed Williams (knee) on injured reserve Saturday.

#1 C

Jake Brendel: Returning to action in Week 10

Nov 7th

Brendel (hamstring) does not have an injury designation for Sunday's battle against the Rams, Nick Wagoner of ESPN.com reports.

#1 LDE

Bryce Huff: Cleared to return Week 10

Nov 7th

Huff (hamstring) does not carry an injury designation into Sunday's game against the Rams, Matt Barrows of The Athletic reports.