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49ers vs Titans Odds, Lines, Spreads & Totals 2025

Titans
16.0 Pts
49ers
28.5 Pts
Sunday December 14, 2025 at 4:25 PM ET
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Titans Injury Report
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49ers Injury Report
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Titans Lineup
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Titans News
#1 SCB
Kevin Winston: Productive vs. Cleveland
Dec 9th
Winston logged five tackles (four solo), including two tackles for a loss, and two pass defenses during the Titans' 31-29 win over the Browns on Sunday.
#1 RILB
Cedric Gray: Keeps stacking up stops
Dec 9th
Gray posted 10 tackles (seven solo) and a fumble recovery in Sunday's 31-29 win over the Titans.
#1 RDE
Jeffery Simmons: Notches 1.5 sacks
Dec 9th
Simmons recorded seven tackles (two solo), 1.5 sacks and a pass breakup in Sunday's 31-29 win over the Browns.
#3 WR
Van Jefferson: Targeted four times
Dec 8th
Jefferson recorded two catches on four targets for 17 yards in Sunday's 31-29 win over the Browns.
#1 TE
Gunnar Helm: One catch in Week 14
Dec 7th
Helm caught one of two targets for eight yards in Sunday's 31-29 win over Cleveland.
#1 K
Joey Slye: Perfect in win
Dec 7th
Slye connected on his only field-goal attempt and all four of his extra-point tries in Sunday's 31-29 win over the Browns.
#2 TE
Chig Okonkwo: Two catches in win
Dec 7th
Okonkwo caught both of his targets for 20 yards in Sunday's 31-29 win over the Browns.
#1 WR
Elic Ayomanor: Hauls in TD in Week 14 win
Dec 7th
Ayomanor caught one of three targets for a 14-yard touchdown Sunday in a 31-29 victory versus Cleveland.
#2 WR
Chimere Dike: Finds end zone in win
Dec 7th
Dike brought in five of eight targets for 24 yards and a touchdown, returned one kickoff for 41 yards and ran back one punt for minus-2 yards in the Titans' 31-29 win over the Browns on Sunday.
#2 RB
Tyjae Spears: Under 50 total yards on 10 touches
Dec 7th
Spears rushed eight times for 19 yards and secured two of four targets for 28 yards in the Titans' 31-29 win over the Browns on Sunday.
#1 QB
Cam Ward: Forgettable numbers despite win
Dec 7th
Ward completed 14 of 28 passes for 117 yards with two touchdowns and one interception while adding two carries for four yards in the Titans' 31-29 win over the Browns on Sunday.
#1 RB
Tony Pollard: Career-best rushing total in win
Dec 7th
Pollard rushed 25 times for 161 yards and two touchdowns in the Titans' 31-29 win over the Browns on Sunday.
#2 NT
Shy Tuttle: Ruled out vs. Browns
Dec 6th
Tuttle (concussion) won't play in Tennessee's matchup versus the Browns on Sunday.
#2 FS
Kendell Brooks: Will play Sunday
Dec 6th
Brooks (concussion) is good to go for Tennessee's matchup versus the Browns on Sunday.
#1 C
Lloyd Cushenberry: Sidelined for second straight
Dec 5th
Cushenberry (foot) has been ruled out ahead of Sunday's game against the Browns, Paul Kuharsky of PaulKuharsky.com reports.
#1 RCB
Jalyn Armour-Davis: Out again Sunday
Dec 5th
Armour-Davis (Achilles) has been ruled out ahead of Sunday's matchup against the Browns, Paul Kuharsky of PaulKuharsky.com reports.
#1 SS
Amani Hooker: Full speed ahead
Dec 3rd
Hooker (ribs) was a full participant at Wednesday's practice.
#3 LILB
James Williams: Good to go Week 13
Nov 30th
Williams (illness) is active for Sunday's game against the Jaguars, Turron Davenport of ESPN.com reports.
#1 LT
Dan Moore: Cleared to play Week 13
Nov 30th
Moore (knee) is active for Sunday's game against the Jaguars, Turron Davenport of ESPN.com reports.
#5 WR
Mason Kinsey: Not playing Sunday
Nov 30th
Kinsey (coach's decision) is inactive for Sunday's matchup with the Jaguars.
#1 FS
Xavier Woods: Will play vs. Jacksonville
Nov 30th
Woods (hamstring) is active for Sunday's game against the Jaguars.
#1 LDE
Sebastian Joseph-Day: Cleared for Week 13
Nov 28th
Joseph-Day (elbow) doesn't carry an injury designation into Sunday's game against the Jaguars.
#3 RCB
Kaiir Elam: Headed to Tennessee
Nov 26th
Elam signed with the Titans on Wednesday, Jim Wyatt of the Titans' official site reports.
SF
49ers News
#3 MLB
Garret Wallow: Joins San Francisco
Dec 8th
The 49ers claimed Wallow off waivers Monday.
#3 LG
Ben Bartch: Officially moved to IR
Dec 8th
The 49ers placed Bartch (foot) on injured reserve Monday.
#3 QB
Kurtis Rourke: Practice window opened
Dec 8th
Rourke (knee) had his 21-day practice window opened Monday by the 49ers.
#3 RDE
Clelin Ferrell: Monster performance vs. Browns
Dec 2nd
Ferrell compiled nine tackles (six solo), including 2.0 sacks, during San Francisco's win over the Browns on Sunday.
#7 WR
Brandon Aiyuk: Not ruled out from playing in 2025
Dec 2nd
San Francisco general manager John Lynch reiterated Tuesday that he's still "hopeful" Aiyuk (knee) will play at some point this season, though he acknowledged that he wasn't sure how realistic the wideout's return might be, Cam Inman of The San Jose Mercury News reports.
#1 MLB
Tatum Bethune: Approaching return to action
Dec 1st
Bethune (ankle) is closing in on a return to action, Matt Barrows of The Athletic reports.
#1 K
Eddy Pineiro: Nearing return to action
Dec 1st
Pineiro (hamstring) is expected to return to action following the 49ers' bye week in Week 14, Matt Barrows of The Athletic reports.
#1 FB
Kyle Juszczyk: Dealing with rib fracture
Dec 1st
Juszczyk is dealing with a rib fracture ahead of the 49ers' bye week, David Lombardi of SFStandard.com reports.
#4 WR
Kendrick Bourne: First target since Week 10
Dec 1st
Bourne was held without a catch (one target) in Sunday's 26-8 win over the Browns.
#3 WR
Demarcus Robinson: Logs first carry of 2025
Dec 1st
Robinson failed to secure his only target while gaining six yards on his first carry of the season in Sunday's 26-8 win over Cleveland.
#2 RB
Brian Robinson: Eight carries in dominant win
Nov 30th
Robinson turned eight carries into 26 yards in Sunday's 26-8 victory over Cleveland.
#1 TE
George Kittle: Paces Niners in receiving yards
Nov 30th
Kittle caught four of five targets for 67 yards in Sunday's 26-8 win over the Browns.
#2 WR
Ricky Pearsall: Just two catches in Cleveland
Nov 30th
Pearsall caught two of three targets for 14 yards in Sunday's 26-8 win over the Browns.
#1 WR
Jauan Jennings: Hauls in TD in Week 13 win
Nov 30th
Jennings caught four of six targets for 39 yards and a touchdown in Sunday's 26-8 win over the Browns.
#1 RB
Christian McCaffrey: Gets into end zone in Week 13
Nov 30th
McCaffrey carried the ball 20 times for 53 yards and a touchdown and caught all four of his targets for 21 yards in Sunday's 26-8 win over the Browns.
#1 QB
Brock Purdy: Produces two TDs in win
Nov 30th
Purdy completed 16 of 29 passes for 168 yards and a touchdown in Sunday's 26-8 win over the Browns. He added four rushing yards and a TD on two carries.
#2 WLB
Nick Martin: Enters concussion protocol
Nov 30th
Martin has entered the league's concussion protocol and has been ruled out for the rest of Sunday's game against the Browns, Cam Inman of The San Jose Mercury News reports.
#4 RB
Jordan James: Inactive Sunday
Nov 30th
James (coach's decision) is inactive for Sunday's game against the Browns, Briana Jeannel of the 49ers' official site reports.
#6 WR
Jordan Watkins: Healthy scratch Sunday
Nov 30th
Watkins (coach's decision) is inactive for Sunday's matchup with the Browns, Briana Jeannel of the 49ers' official site reports.
#2 RDE
Robert Beal: Looking good for Sunday
Nov 28th
Beal (concussion) does not carry an injury designation ahead of Sunday's game at Cleveland, Noah Furtado of the San Francisco Chronicle reports.
#1 SLB
Luke Gifford: Will play Sunday
Nov 28th
Gifford (hip/neck) is good to go for San Francisco's matchup versus the Browns on Sunday, Noah Furtado of the San Francisco Chronicle reports.
#1 RDE
Sam Okuayinonu: Set to miss Week 13
Nov 26th
Okuayinonu (ankle) is expected to miss multiple weeks, Matt Barrows of The Athletic reports.
#4 RDE
Yetur Gross-Matos: Will remain on IR
Nov 26th
Head coach Kyle Shanahan relayed Wednesday that the 49ers will not designate Gross-Matos (knee) to return from injured reserve, Matt Maiocco of NBC Sports Bay Area reports.