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49ers vs Rams Odds, Lines, Spreads & Totals 2025

Rams
27.0 Pts
49ers
22.5 Pts
Sunday November 9, 2025 at 4:25 PM ET
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49ers Injury Report
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Rams Lineup
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Rams News
#4 RB
Ronnie Rivers: Signing with active roster
Nov 5th
The Rams signed Rivers to their active roster Wednesday, Wyatt Miller of the team's official site reports.
#1 K
Joshua Karty: Facing competition from Mevis
Nov 5th
Rams head coach Sean McVay said Wednesday that Karty will face competition from Harrison Mevis for the kicking job this week, Adam Grosbard of The Orange County Register reports.
#1 WR
Puka Nacua: Limited to begin Week 10 prep
Nov 5th
Coach Sean McVay said that imaging on Nacua's ribs returned negative, and while the wide receiver will be limited at Wednesday's practice, he should be able to play Sunday at San Francisco, Adam Grosbard of The Orange County Register reports.
#1 LCB
Darious Williams: Optimism for Week 10
Nov 5th
Rams head coach Sean McVay said Wednesday that "the plan we had in place" is for Williams (shoulder) to return to the lineup Sunday against the 49ers, Cameron DaSilva of USA Today reports.
#1 LILB
Nate Landman: Five tackles against New Orleans
Nov 4th
Landman recorded five tackles (zero solo) and one forced fumble in the Rams' win over the Saints on Sunday.
#3 TE
Davis Allen: Season-high three catches
Nov 3rd
Allen secured three of four targets for 37 yards during Sunday's 34-10 win against the Saints.
#2 TE
Terrance Ferguson: Season-high 54 yards in win
Nov 3rd
Ferguson secured two of three targets for 54 yards during Sunday's 34-10 victory against the Saints.
#4 WR
Konata Mumpfield: Fails to record a target
Nov 3rd
Mumpfield played 30 snaps on offense during Sunday's 34-10 victory against the Saints.
#5 WR
Xavier Smith: Makes a pair of grabs
Nov 3rd
Smith secured two of three targets for 12 yards and returned two punts for 11 yards during Sunday's 34-10 win against the Saints.
#3 WR
Jordan Whittington: Uninvolved in victory
Nov 3rd
Whittington failed to record a target during Sunday's 34-10 victory against the Saints.
#1 TE
Tyler Higbee: Finds end zone early in win
Nov 2nd
Higbee recorded three receptions on four targets for 13 yards and a touchdown in Sunday's 34-10 win over the Saints.
#2 RB
Blake Corum: Benefits from blowout win
Nov 2nd
Corum recorded 13 rushes for 58 yards in Sunday's 34-10 win over the Saints.
#2 WR
Davante Adams: Another multi-touchdown effort
Nov 2nd
Adams recorded five receptions on seven targets for 60 yards and two touchdowns in Sunday's 34-10 win over the Saints.
#1 RB
Kyren Williams: Tops 100 yards against Saints
Nov 2nd
Williams rushed the ball 25 times for 114 yards and one touchdown in Sunday's 34-10 win over the Saints.
#1 QB
Matthew Stafford: Barrage of touchdowns continues
Nov 2nd
Stafford completed 24 of 32 passes for 281 yards, four touchdowns and zero interceptions in Sunday's 34-10 win over the Saints. He also had four rushes for minus-4 yards.
#3 QB
Stetson Bennett: Emergency QB3 for Week 9
Nov 2nd
Bennett (coach's decision) is inactive but will serve as the Rams' emergency third quarterback against the Saints on Sunday.
#3 RB
Jarquez Hunter: Won't play against New Orleans
Nov 2nd
Hunter (coach's decision) is inactive for Sunday's game against the Saints.
#1 RT
Rob Havenstein: Set to face Saints
Oct 31st
Havenstein (ankle) has no injury designation ahead of Sunday's game against the Saints, Adam Grosbard of The Orange County Register reports.
#1 FS
Kamren Kinchens: Good to go vs. New Orleans
Oct 31st
Kinchens (toe) does not carry an injury designation into Sunday's game against the Saints, Adam Grosbard of The Orange County Register reports.
#2 SCB
Roger McCreary: Ready for Sunday
Oct 31st
After being traded from the Titans to the Rams on Tuesday, McCreary is available for Sunday's matchup against the Saints, Nate Atkins of The Athletic reports.
#6 WR
Tutu Atwell: Sent to IR
Oct 27th
The Rams placed Atwell (hamstring) on injured reserve Monday.
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49ers News
#2 WR
Ricky Pearsall: Not practicing Wednesday
Nov 5th
Pearsall (knee) isn't practicing Wednesday, Matt Barrows of The Athletic reports.
#7 WR
Brandon Aiyuk: Expected to play this year, eventually
Nov 5th
San Francisco head coach Kyle Shanahan said Wednesday that he's "pretty confident" Aiyuk (knee) will play at some point this season, David Lombardi of SFStandard.com reports.
#1 QB
Brock Purdy: To be limited Wednesday
Nov 5th
Coach Kyle Shanahan said Purdy (toe) will be limited at Wednesday's practice, Matt Barrows of The Athletic reports.
#4 RDE
Mykel Williams: Diagnosed with torn ACL
Nov 3rd
Head coach Kyle Shanahan said Monday that Williams tore his ACL during the fourth quarter of Sunday's 34-24 win over the Giants, Matt Barrows and Dianna Russini of The Athletic report.
#6 WR
Jordan Watkins: Another one-catch outing Sunday
Nov 3rd
Watkins hauled in his only target for 19 yards in Sunday's 34-24 win over the Giants.
#5 WR
Skyy Moore: Busy day returning kicks
Nov 3rd
Moore had one reception for 21 yards while returning five combined kicks for 85 yards in Sunday's 34-24 win over the Giants.
#4 WR
Demarcus Robinson: Continues to disappoint
Nov 3rd
Robinson finished with no receptions (on one target) in Sunday's 34-24 win over the Giants.
#2 RB
Brian Robinson: Best game with San Francisco
Nov 3rd
Robinson took five carries for 53 yards and a touchdown in Sunday's 34-24 win over the Giants. He also returned a kickoff for 41 yards.
#1 MLB
Tatum Bethune: Career high in tackles in win
Nov 2nd
Bethune recorded 16 total tackles (eight solo) and a pass defensed in Sunday's 34-24 win over the Giants.
#1 K
Eddy Pineiro: Makes six kicks in Week 9 win
Nov 2nd
Pineiro made both of his field-goal attempts and connected on all four of his point-after tries during the 49ers' 34-24 win over the Giants on Sunday.
#3 WR
Kendrick Bourne: Held to two catches in Week 9
Nov 2nd
Bourne caught both of his targets for 34 yards in Sunday's 34-24 win over the Giants.
#1 WR
Jauan Jennings: Scores TD in Week 9 win
Nov 2nd
Jennings caught four of five targets for 41 yards and a touchdown in Sunday's 34-24 win over the Giants.
#1 TE
George Kittle: Four catches in Week 9 win
Nov 2nd
Kittle caught all four of his targets for 32 yards in Sunday's 34-24 win over the Giants.
#2 QB
Mac Jones: Accurate start in Week 9 win
Nov 2nd
Jones completed 19 of 24 passes for 235 yards and two touchdowns in Sunday's 34-24 win over the Giants. He added four rushing attempts for four yards and lost a fumble.
#1 RB
Christian McCaffrey: Racks up 173 totals yards, two TDs
Nov 2nd
McCaffrey rushed 28 times for 106 yards and a touchdown while catching five of six targets for 67 yards and a touchdown in Sunday's 34-24 win over the Giants.
#2 DT2
Jordan Elliott: Cleared to play Week 9
Nov 2nd
Elliott (ankle) is active for Sunday's game against the Giants, Briana Jeannel of the 49ers' official site reports.
#1 LG
Spencer Burford: Officially cleared for Week 9
Nov 2nd
Burford (knee) is active for Sunday's game against the Giants, Briana Jeannel of the 49ers' official site reports.
#2 FS
Marques Sigle: Healthy scratch Sunday
Nov 2nd
Sigle (coach's decision) is inactive for Sunday's game against the Giants, Briana Jeannel of the 49ers' official site reports.
#1 RDE
Sam Okuayinonu: Good to go Sunday
Nov 2nd
Okuayinonu (ankle) is active for Sunday's matchup with the Giants, Briana Jeannel of the 49ers' official site reports.
#1 WLB
Dee Winters: Playing Sunday
Nov 2nd
Winters (knee) is active for Sunday's contest against the Giants, Briana Jeannel of the 49ers' official site reports.
#3 LG
Ben Bartch: Ruled out for Week 9
Nov 1st
Bartch (ankle) has been ruled out ahead of Sunday's game against the Giants.
#3 RDE
Yetur Gross-Matos: Lands on IR
Nov 1st
Gross-Matos (knee) was placed on injured reserve Saturday.
#1 C
Jake Brendel: Sidelined again
Oct 31st
Brendel (hamstring) was ruled out ahead of Sunday's matchup against the Giants,Jennifer Lee Chan of NBC Sports Bay Area reports.
#1 SCB
Upton Stout: Cleared for Week 9
Oct 31st
Stout (shoulder) has no injury designation ahead of Sunday's game against the Giants.
#1 LDE
Bryce Huff: Out for Week 9
Oct 31st
Huff (hamstring) has been ruled out for Sunday's game against the Giants, Jennifer Lee Chan of NBC Sports Bay Area reports.
#1 LCB
Renardo Green: Posts eight stops vs. Houston
Oct 30th
Green registered eight tackles (four solo) during the 49ers' 26-15 loss to the Texans on Sunday.
#1 RCB
Deommodore Lenoir: Haults in first INT of 2025
Oct 30th
Lenoir registered three tackles (two solo) and one interception during the 49ers' 26-15 loss to the Texans on Sunday.
#3 TE
Jake Tonges: Scores, but plays just five snaps
Oct 29th
Tonges recorded a two-yard touchdown reception on his lone target while playing five of the 49ers' 48 snaps on offense in Sunday's 26-15 loss to the Texans.
#3 RB
Isaac Guerendo: No run on offense this season
Oct 29th
Guerendo played all 10 of his snaps on special teams in Sunday's 26-15 loss to the Texans.
#1 FS
Malik Mustapha: Season-high stops in Week 8 loss
Oct 28th
Mustapha made 12 tackles (six solo) during Sunday's loss to the Texans.
#2 LDE
Keion White: Sent to Bay Area
Oct 28th
The 49ers acquired White and a 2026 seventh-round pick from the Patriots on Tuesday in exchange for a 2026 sixth-round pick, Tom Pelissero of NFL Network reports.
#1 SLB
Luke Gifford: Good to go
Oct 26th
Gifford is active for Sunday's game against the Texans.