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Giants vs Chiefs Odds, Lines, Spreads & Totals 2025

Chiefs
26.0 Pts
Giants
19.5 Pts
Sunday September 21, 2025 at 8:20 PM ET
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KC
Chiefs Injury Report
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NYG
Giants Injury Report
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KC
Chiefs Lineup
Inactives
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NYG
Giants Lineup
Inactives
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KC
Chiefs News
#7 WR
Nikko Remigio: Snares lone target against Philly
Sep 16th
Remigio reeled in his only target for 21 yards during Sunday's 20-17 loss against the Eagles.
#3 RB
Brashard Smith: Tallies first career carry
Sep 16th
Smith accrued one rush for two yards and failed to gather his lone target during Sunday's 20-17 loss to the Eagles.
#4 WR
JuJu Smith-Schuster: Minimal output versus Eagles
Sep 16th
Smith-Schuster had one reception (on three targets) for five yards during Sunday's 20-17 defeat to the Eagles.
#1 K
Harrison Butker: Misses field goal in Week 2
Sep 15th
Butker went 1-for-2 on field-goal attempts and made both of his extra-point tries in Sunday's 20-17 loss to the Eagles.
#3 WR
Tyquan Thornton: Rips off long TD grab
Sep 14th
Thornton brought in two of five targets for 59 yards and a touchdown in Sunday's 20-17 loss to the Eagles.
#2 RB
Kareem Hunt: Gains 34 yards on nine touches
Sep 14th
Hunt took eight carries for 31 yards and caught his only target for three yards in Sunday's 20-17 loss to the Eagles.
#1 RB
Isiah Pacheco: Struggles on 10 carries Sunday
Sep 14th
Pacheco rushed 10 times for 22 yards while catching one of two targets for seven yards in Sunday's 20-17 loss to Philadelphia.
#2 WR
Hollywood Brown: Grabs five receptions in loss
Sep 14th
Brown hauled in all five of his targets for 30 yards in Sunday's 20-17 loss to the Eagles.
#1 TE
Travis Kelce: Leading receiver Sunday
Sep 14th
Kelce had four receptions on six targets for 61 yards in Sunday's 20-17 loss to the Eagles.
#1 QB
Patrick Mahomes: Another loss with two touchdowns
Sep 14th
Mahomes completed 16 of 29 pass attempts for 187 yards, one touchdown and one interception while taking seven carries for 66 yards and another score in Sunday's 20-17 loss to the Eagles.
#1 RDE
Mike Danna: Dealing with quad issue
Sep 14th
Danna suffered a quadriceps injury in Sunday's 20-17 loss to the Eagles, Charles Goldman of AtoZSports.com reports.
#2 RCB
Kristian Fulton: Officially done for day
Sep 14th
Fulton (ankle) has been ruled out for the rest of Sunday's game against the Eagles.
#4 RB
Elijah Mitchell: Won't play versus Eagles
Sep 14th
Mitchell (coach's decision) has been ruled out for Kansas City's matchup versus the Eagles on Sunday.
#1 WR
Xavier Worthy: Trending toward Week 3 return
Sep 14th
Worthy (shoulder) has been ruled out ahead of Sunday's game against the Eagles, but the Chiefs believe the receiver is "looking good" to play Week 3 against the Giants, Ian Rapoport of NFL Network reports.
#5 WR
Jalen Royals: Pro debut delayed again
Sep 12th
Royals (knee) has been ruled out for Sunday's contest against the Eagles.
#1 WLB
Drue Tranquill: Upgrades to full practice Thursday
Sep 11th
Tranquill (knee) was a full participant in Thursday's practice.
#1 DT2
Omarr Norman-Lott: Practices in full Wednesday
Sep 10th
Norman-Lott (ankle) was a full participant at practice Wednesday.
#1 SS
Jaden Hicks: Sees snaps at slot Week 1
Sep 7th
Hicks finished Friday's 27-21 loss to the Chargers with four tackles (three solo).
#1 LDT
Chris Jones: Two tackles vs. Bolts
Sep 7th
Jones recorded two assisted tackles during the Chiefs' 27-21 loss to the Chargers on Friday.
#1 LDE
George Karlaftis: Records Week 1 sack
Sep 7th
Karlaftis notched three tackles (two solo), including 1.0 sacks, in Friday's Week 1 loss to the Chargers.
#1 RCB
Jaylen Watson: Starts at outside corner
Sep 6th
Watson recorded six tackles (five solo) and one pass defensed in Friday's 27-21 loss to the Chargers.
#1 LCB
Trent McDuffie: Plays every defensive snap
Sep 6th
McDuffie recorded five tackles (four solo) and one pass defensed in Friday's 27-21 loss to the Chargers.
#1 FS
Bryan Cook: Three tackles in opener
Sep 6th
Cook recorded three tackles in Friday's 27-21 loss to the Chargers.
#2 TE
Noah Gray: Secures only target in Week 1 loss
Sep 6th
Gray brought in his lone target for three yards during the Chiefs' 27-21 loss to the Chargers on Friday night.
#1 SCB
Chamarri Conner: Leads KC with 10 tackles
Sep 5th
Conner finished Friday's 27-21 loss to the Chargers with 10 tackles (seven solo) and a forced fumble.
#1 MLB
Nick Bolton: Logs eight tackles against Bolts
Sep 5th
Bolton collected eight tackles (six solo) during the Chiefs' 27-21 loss to the Chargers on Friday.
#4 TE
Jared Wiley: Sitting out Week 1
Sep 5th
Wiley (coach's decision) is inactive for Friday's game against the Chargers, Matt McMullen of the Chiefs' official site reports.
#2 MLB
Jack Cochrane: Recovered from knee injury
Sep 2nd
Cochrane (knee) was listed as a full participant in Tuesday's practice report.
NYG
Giants News
#1 SCB
Dru Phillips: Shines with INT in Week 2
Sep 15th
Phillips registered 11 tackles (eight solo) and two pass defenses, including an interception, in Sunday's loss to the Cowboys.
#1 LCB
Paulson Adebo: Racks up 13 stops in Week 2
Sep 15th
Adebo posted 13 tackles (11 solo) and a defensed pass Sunday in an overtime loss to the Cowboys.
#1 SS
Tyler Nubin: Tallies five stops Week 2
Sep 15th
Nubin recorded five tackles (all solo) in Sunday's overtime defeat against Dallas.
#1 LILB
Bobby Okereke: Racks up double-digit stops again
Sep 15th
Okereke finished with 10 tackles (four solo) and a defensed pass in Sunday's Week 2 overtime loss to the Cowboys.
#2 TE
Daniel Bellinger: Gets zero targets Week 2
Sep 15th
Bellinger did not receive any passing targets Sunday in an overtime defeat against Dallas.
#1 TE
Theo Johnson: Picks up production Week 2
Sep 15th
Johnson caught four of five targets for 34 yards in Sunday's overtime loss to the Cowboys.
#4 WR
Jalin Hyatt: Doesn't see field again Week 2
Sep 15th
Hyatt did not log any snaps Sunday in an overtime loss to Dallas.
#3 WR
Darius Slayton: Hauls in 52-yard reception
Sep 15th
Slayton caught two of three targets for 61 yards in a Week 2 overtime loss to the Cowboys on Sunday.
#3 RB
Devin Singletary: Nets zero yards in minor role
Sep 15th
Singletary rushed once for four yards and caught his only target for minus-4 yards in Sunday's Week 2 overtime loss to Dallas.
#1 K
Graham Gano: Connects on three FGAs in loss
Sep 14th
Gano went 3-for-3 on field-goal attempts and made three PATs in Sunday's 40-37 overtime loss to the Cowboys.
#2 WR
Wan'Dale Robinson: Career-best numbers in Dallas
Sep 14th
Robinson caught eight of 10 targets for 142 yards and a touchdown in Sunday's 40-37 overtime loss to the Cowboys.
#1 RB
Cam Skattebo: Scores first career TD in OT loss
Sep 14th
Skattebo carried the ball 11 times for 45 yards and a touchdown and caught two of three targets for 14 yards in Sunday's 40-37 overtime loss to the Cowboys.
#2 RB
Tyrone Tracy: Takes back seat to rookie
Sep 14th
Tracy carried the ball five times for 15 yards and caught four of five targets for 36 yards in Sunday's 40-27 overtime loss to the Cowboys.
#1 QB
Russell Wilson: Tops 400 yards in tough OT loss
Sep 14th
Wilson completed 30 of 41 passes for 450 yards and three touchdowns with one interception in Sunday's 40-37 overtime loss to the Cowboys. He added 23 yards on three carries.
#1 WR
Malik Nabers: Massive numbers in OT loss
Sep 14th
Nabers caught nine of 13 targets for 167 yards and two touchdowns in Sunday's 40-37 overtime loss to the Cowboys.
#2 RILB
Chris Board: Ruled out Sunday
Sep 14th
Board (chest) has been ruled out for the remainder of the Giants' matchup versus the Cowboys on Sunday, Dan Salomone of the Giants' official site reports.
#1 RILB
Darius Muasau: Out with concussion
Sep 14th
Muasau has been ruled out for the rest of the Giants' matchup with the Cowboys on Sunday due to a concussion, Dan Salomone of the Giants' official site reports.
#1 LT
Andrew Thomas: Inactive Week 2
Sep 14th
Thomas (foot) is inactive for Sunday's game against the Cowboys, Dan Salomone of the Giants' official site reports.
#1 LDE
Rakeem Nunez-Roches: Ruled out Week 2
Sep 14th
Nunez-Roches (foot) is inactive for Sunday's game against the Cowboys, Dan Salomone of the Giants' official site reports.
#3 QB
Jameis Winston: Again serving as emergency QB
Sep 14th
Winston (coach's decision) is inactive for Sunday's game against the Cowboys but is serving as the Giants emergency quarterback.
#2 LILB
Demetrius Flannigan-Fowles: Won't play Sunday
Sep 12th
Flannigan-Fowles (calf) has been ruled out ahead of Sunday's matchup against the Cowboys, Dan Salomone of the Giants' official site reports.
#3 RILB
Micah McFadden: Placed on injured reserve
Sep 11th
The Giants placed McFadden (foot) on injured reserve Thursday.
#7 WR
Xavier Gipson: Stays in Big Apple with Big Blue
Sep 11th
Gipson was claimed off waivers by the Giants on Thursday, Ian Rapoport of NFL Network reports.
#1 FS
Jevon Holland: Logs seven tackles
Sep 9th
Holland recorded seven tackles (three solo) and one pass deflection in the Giants' loss to the Commanders.
#1 NT
Dexter Lawrence: Tallies three tackles
Sep 9th
Lawrence logged three tackles in the Giants' loss versus the Commanders on Sunday.
#1 WLB
Brian Burns: Tallies 2.0 sacks Week 1
Sep 8th
Burns registered six tackles (two solo), including 2.0 sacks, in Sunday's loss to the Commanders.
#2 RDE
Darius Alexander: Won't make NFL debut vs. WAS
Sep 7th
Alexander (coach's decision) is inactive for Sunday's game against the Commanders, Dan Salomone of the Giants' official site reports.
#4 TE
Thomas Fidone: Healthy scratch Week 1
Sep 7th
Fidone (coach's decision) is inactive for Sunday's NFC East clash against the Commanders, Dan Salomone of the Giants' official site reports.
#2 QB
Jaxson Dart: Could have role in Week 1 game plan
Sep 7th
Dart will be active as the top backup to Russell Wilson in Sunday's game at Washington, and the Giants could have a package of plays designed for the rookie quarterback, Dan Graziano of ESPN.com reports.