Injury hotspots for Week 6 include Seattle's secondary, the Chargers' offensive line, New England's secondary, Tampa Bay's receiving corps, the Cowboys' entire roster, Detroit's secondary and Green Bay's offensive line.
Below you'll find four different categories, with our lists including key offensive linemen and defensive players whose absences might impact fantasy decisions. The bottom section, for potential game-day decisions, is sorted by kickoff times. It can be used as a checklist/cheatsheet for Sunday morning and afternoon when inactives come out and we need to adjust lineups. Before we get to the 'questionable' players, let's see who's definitely in and who's definitely out...
Good to Go 💯
 RB Tyjae Spears (ankle) RB Tyjae Spears (ankle)
 RB Bhayshul Tuten (shoulder) RB Bhayshul Tuten (shoulder)
 RB Kyle Monangai (thigh) RB Kyle Monangai (thigh)
 WR Xavier Worthy (shoulder/ankle) WR Xavier Worthy (shoulder/ankle)
 WR Amon-Ra St. Brown (wrist) WR Amon-Ra St. Brown (wrist)
 WR Alec Pierce (concussion) WR Alec Pierce (concussion)
 WR Dyami Brown (shoulder) WR Dyami Brown (shoulder)
 TE Darren Waller (hip) TE Darren Waller (hip)
 TE Juwan Johnson (ankle) TE Juwan Johnson (ankle)
 TE Tyler Higbee (hip) TE Tyler Higbee (hip)
 TE Michael Mayer (concussion) TE Michael Mayer (concussion)
Ruled Out/Doubtful 🚑
Out/Doubtful/IR
 QB Lamar Jackson (hamstring) QB Lamar Jackson (hamstring)
 QB Brock Purdy (toe) QB Brock Purdy (toe)
 RB Chuba Hubbard (calf) RB Chuba Hubbard (calf)
 RBs Bucky Irving (shoulder/ankle) & Josh Williams (concussion) RBs Bucky Irving (shoulder/ankle) & Josh Williams (concussion)
 RB Antonio Gibson (knee - out for season) RB Antonio Gibson (knee - out for season)
 RB Miles Sanders (knee - out for season) RB Miles Sanders (knee - out for season)
 RB Tyler Goodson (groin) RB Tyler Goodson (groin)
 WRs CeeDee Lamb (ankle) & KaVontae Turpin (foot) WRs CeeDee Lamb (ankle) & KaVontae Turpin (foot)
 WRs Mike Evans (hamstring) & Chris Godwin (fibula) WRs Mike Evans (hamstring) & Chris Godwin (fibula)
 WR Ricky Pearsall (knee) WR Ricky Pearsall (knee)
 WR Calvin Austin (shoulder) WR Calvin Austin (shoulder)
 WR Christian Watson (IR - knee) WR Christian Watson (IR - knee)
 WR Allen Lazard (personal) WR Allen Lazard (personal)
 TE Brock Bowers (knee) TE Brock Bowers (knee)
 TE Brenton Strange (quad - out 5+ weeks) TE Brenton Strange (quad - out 5+ weeks)
 K Joey Slye (calf) K Joey Slye (calf)
Unlike yesterday, Mac Jones was back to throwing at today's practice. Jauan Jennings also was on hand for second straight day.
No Brock Purdy or Ricky Pearsall. Purdy seen pushing a weight sled, suggesting his big toe is making progress.
— Matt Barrows (@mattbarrows) October 10, 2025
On @1053thefan, Stephen Jones said Miles Sanders season is over due to knee injury that will require surgery. pic.twitter.com/Ds01TIbuvj
— Todd Archer (@toddarcher) October 10, 2025
Potential Workload Beneficiaries (From Injuries Above)
 QB Cooper Rush QB Cooper Rush
 QB Mac Jones (knee/oblique) QB Mac Jones (knee/oblique)
 RBs Rico Dowdle, Trevor Etienne & DeeJay Dallas RBs Rico Dowdle, Trevor Etienne & DeeJay Dallas
 RBs Rachaad White & Sean Tucker RBs Rachaad White & Sean Tucker
 RBs Rhamondre Stevenson & TreVeyon Henderson RBs Rhamondre Stevenson & TreVeyon Henderson
 WRs Jalen Tolbert & Ryan Flournoy WRs Jalen Tolbert & Ryan Flournoy
 WRs Sterling Shepard & Tez Johnson WRs Sterling Shepard & Tez Johnson
 WRs Kendrick Bourne & Demarcus Robinson WRs Kendrick Bourne & Demarcus Robinson
 WRs Roman Wilson, Scotty Miller & Ben Skowronek WRs Roman Wilson, Scotty Miller & Ben Skowronek
 TE Michael Mayer TE Michael Mayer
 TE Hunter Long TE Hunter Long
 K Matthew Wright K Matthew Wright
Expecting #Bucs WRs Sunday to look like:
— Adam Levitan (@adamlevitan) October 10, 2025
1. Emeka Egbuka
2. Sterling Shepard (slot)
3. Tez Johnson
4. Ryan Miller https://t.co/jDxae89ORH
Key Defensive Players + Offensive Linemen
 CB Devon Witherspoon (knee), CB Riq Woolen (head), S Julian Love (hamstring) CB Devon Witherspoon (knee), CB Riq Woolen (head), S Julian Love (hamstring)
 CB Kenny Moore (Achilles) CB Kenny Moore (Achilles)
 LB Tyrel Dodson (concussion) LB Tyrel Dodson (concussion)
 S Jaylinn Hawkins (hamstring) S Jaylinn Hawkins (hamstring)
 DT Devonte Wyatt (knee) DT Devonte Wyatt (knee)
 CB Terrion Arnold (shoulder) CB Terrion Arnold (shoulder)
 LB Jonah Elliss (ribs) LB Jonah Elliss (ribs)
 LB Omar Speights (high ankle) LB Omar Speights (high ankle)
 LB Jonah Elliss (ribs) + G Ben Powers (biceps) LB Jonah Elliss (ribs) + G Ben Powers (biceps)
 LB Roquan Smith (hamstring) + FB Patrick Ricard (calf) + CB Chidobe Awuzie (hamstring) LB Roquan Smith (hamstring) + FB Patrick Ricard (calf) + CB Chidobe Awuzie (hamstring)
 G Tyler Booker (ankle) + LB Jack Sanborn (head) G Tyler Booker (ankle) + LB Jack Sanborn (head)
 C Robert Hainsey (D - hamstring) C Robert Hainsey (D - hamstring)
 RT Taylor Moton (elbow) RT Taylor Moton (elbow)
 LT Joe Alt (ankle) + RT Trey Pipkins (knee) LT Joe Alt (ankle) + RT Trey Pipkins (knee)
Seahawks released their final injury report. Team is going to once again be shorthanded in the secondary pic.twitter.com/KiaL86Oicc
— Dugar, Michael-Shawn (@MikeDugar) October 10, 2025
Shaquill Griffin will "be part of the plan" for Sunday's game, Macdonald says.
— Dugar, Michael-Shawn (@MikeDugar) October 10, 2025
Listed as Questionable - Should Play 👍
 QB Mac Jones (oblique/knee) QB Mac Jones (oblique/knee)
 WR Van Jefferson (ankle) WR Van Jefferson (ankle)
 WR Deebo Samuel (calf) WR Deebo Samuel (calf)
 TE Colby Parkinson (concussion) TE Colby Parkinson (concussion)
49ers ruled out QB Brock Purdy and WR Ricky Pearsall for Sunday's game at Tampa Bay.
49ers QB Mac Jones starts again. pic.twitter.com/7FQglh7QKN
— Adam Schefter (@AdamSchefter) October 10, 2025
Truly Questionable / Game-Time Decisions 🤔
Early Games
 QB Kyler Murray (toe) QB Kyler Murray (toe)
 RB Alvin Kamara (ankle) RB Alvin Kamara (ankle)
 WR Zay Flowers (shoulder) WR Zay Flowers (shoulder)
 WR Quentin Johnston (hamstring) WR Quentin Johnston (hamstring)
 WR Tutu Atwell (hamstring) WR Tutu Atwell (hamstring)
 WR Jonathan Mingo (IR - knee) WR Jonathan Mingo (IR - knee)
 WR Zay Jones (knee) WR Zay Jones (knee)
 WR Jalen Coker (IR - quad) & TE Ja'Tavion Sanders (ankle) WR Jalen Coker (IR - quad) & TE Ja'Tavion Sanders (ankle)
Flowers seems likely to play, while Murray, Kamara and Johnston are more up in the air. All were limited practice participants Friday, potentially setting up game-day decision heading into the weekend. Early kickoffs are good news for fantasy managers.
"That's one of the reasons I chose this place."
Arizona Cardinals QB Jacoby Brissett is confident partly because of his familiarity with the offense @PHNX_Cardinals pic.twitter.com/VWIsO3Bvwy
— Bo Brack (@BoBrack) October 10, 2025
Late-Afternoon Games
 WR Jauan Jennings (ankle/rib) WR Jauan Jennings (ankle/rib)
 WR Ja'Marr Chase (illness) WR Ja'Marr Chase (illness)
 K Brandon McManus (leg) K Brandon McManus (leg)
All three of these guys seem more likely than not to play. If not, Kendrick Bourne and Tee Higgins would be the No. 1 receivers for their respective teams, catching passes from Mac Jones and Joe Flacco.
Primetime Games
 WR Kalif Raymond (neck) - SNF WR Kalif Raymond (neck) - SNF
 TE Dalton Kincaid (oblique) + WR Curtis Samuel (neck/ribs) - MNF 7:15 ET TE Dalton Kincaid (oblique) + WR Curtis Samuel (neck/ribs) - MNF 7:15 ET
 WR Darnell Mooney (hamstring) - MNF 7:15 ET WR Darnell Mooney (hamstring) - MNF 7:15 ET
 WRs Terry McLaurin (quad) & Noah Brown (knee) - MNF 8:15 ET WRs Terry McLaurin (quad) & Noah Brown (knee) - MNF 8:15 ET
 RB Chris Rodriguez (calf) - MNF 8:15 ET RB Chris Rodriguez (calf) - MNF 8:15 ET
 TE Colston Loveland (hip) - MNF 8:15 ET TE Colston Loveland (hip) - MNF 8:15 ET
It isn't looking good for Mooney, McLaurin and Rodriguez, all listed as 'DNP' both Thursday and Friday. The others here all managed varying levels of practice participation. Kincaid seems on track to play.
Key Defensive Players + O-Linemen
 CB Christian Gonzalez (hamstring) CB Christian Gonzalez (hamstring)
 CB Max Melton (hamstring) + LB Mack Wilson (ankle) CB Max Melton (hamstring) + LB Mack Wilson (ankle)
 CB DaRon Bland (shoulder) + CB Trevon Diggs (knee) + G Tyler Smith (knee) CB DaRon Bland (shoulder) + CB Trevon Diggs (knee) + G Tyler Smith (knee)
 CB Jalen Ramsey (hamstring CB Jalen Ramsey (hamstring
 CB A.J. Terrell (hamstring) CB A.J. Terrell (hamstring)
 S Brian Branch (ankle), S Kerby Joseph (knee), CB Avonte Maddox (hamstring) S Brian Branch (ankle), S Kerby Joseph (knee), CB Avonte Maddox (hamstring)
 T Taylor Decker (shoulder) T Taylor Decker (shoulder)
 G Aaron Banks (groin), T Zach Tom (oblique), T Rasheed Walker (quad) G Aaron Banks (groin), T Zach Tom (oblique), T Rasheed Walker (quad)
 C Aaron Brewer (pectoral) + CB Storm Duck (ankle) C Aaron Brewer (pectoral) + CB Storm Duck (ankle)
 DT Grady Jarrett (knee) + CB Kyler Gordon (hamstring) + RT Darnell Wright (elbow) DT Grady Jarrett (knee) + CB Kyler Gordon (hamstring) + RT Darnell Wright (elbow)
 DT Ed Oliver (ankle) + LB Matt Milano (pec) DT Ed Oliver (ankle) + LB Matt Milano (pec)
Right tackle Zach Tom (oblique) said he was able to exert himself in practice this week and feels good about playing Sunday and also being able to go the distance.
"Having the confidence that your body is going to hold up is obviously huge."
— Rob Demovsky (@RobDemovsky) October 10, 2025
Lengthy injury report has Detroit Lions with 4 players out, 6 questionable https://t.co/FZqfPtplAa
— MLive Sports (@MLiveSports) October 10, 2025
Cowboys injury report still long pic.twitter.com/5bW4snK89s
— Clarence Hill Jr (@clarencehilljr) October 10, 2025

 
		 
                    












 
				