Nico Collins could see an enormous target share with the Texans managing multiple wideout injuries.
CeeDee Lamb could have one of his biggest games playing against a Lions defense that's tougher against the run than the pass.
DK Metcalf could pose a major big-play threat to Tennessee's injury-challenged corner rotation.
If New England prioritizes defending Travis Kelce then the Pats might not have leftover personnel to cover Rashee Rice.
Ja'Marr Chase should keep rolling against a Colts secondary with poor boundary corner personnel.
The Saints are tougher on the boundary than in the slot, which should provoke a big game from Amon-Ra St. Brown.
The Indianapolis secondary is weakest on the boundary and downfield, where Mike Evans is at his best.
It might be now or never for DeAndre Hopkins, who catches the Colts battered and weak at cornerback.
Drake London is due for a bounce-back after no catches in Week 1, but Jaire Alexander could deny it anyway.
With better coverage in the seam than the perimeter, expect Mike Evans to hit the ground running against the Chiefs.