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Best Bets for Carolina Panthers vs. San Francisco 49ers | Carolina Panthers +7.5 (-110)
Bryce Young and the Carolina Panthers take on Brock Purdy's San Francisco 49ers to close out Week 12 on Monday Night Football. Oddsmakers are laying -7.5 with the 49ers as home favorites, with a 49.5 point total.
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Carolina has been good on the road lately. Head coach Dave Canales has dialed up a strong blend of run and pass, allowing Panthers RB Rico Dowdle to get relief with Young's passing development.
The 49ers have allowed between 275 and 452 passing yards in three of their previous four games. Due to injuries, expect Carolina's offense to have success sustaining drives, turning them into points.
The Panthers now have a path to gain the lead in the NFC South following Tampa Bay's loss to the Rams on Sunday Night Football. Let's bet Carolina +7.5 against a porous San Francisco defense.
Best Bets for Carolina Panthers vs. San Francisco 49ers | George Kittle Anytime Touchdown Scorer (+140)
Brock Purdy has wasted no time targeting his All-Pro tight end, George Kittle. Following Purdy's return from injury in Week 11, Kittle scored twice on six targets, hauling in all six passes for 67 receiving yards.
The Panthers' defense has allowed five different tight ends to score a touchdown in 2025. San Francisco's offense will make several red zone trips against a Carolina defense that has surrendered 348-plus total yards of offense in four straight matchups.
Let's bet on the 49ers' top pass catcher, Kittle, to score a touchdown for a third straight game in a favorable matchup against Carolina on Monday Night Football.
Best Bets for Carolina Panthers vs. San Francisco 49ers | Bryce Young O 213.5 Passing Yards (-110)
Bryce Young is coming off a career-high 448 passing yards in an overtime win against Atlanta in Week 11. Young's drawing a good matchup against the 49ers' secondary, which has allowed 230 or more passing yards in six of its previous seven outings.
Young has only gone over 213.5 passing yards twice in 2025. We're going to invest in Canales' play-calling and trust a pass-centric gameplan, especially since the 49ers are better at defending the run.
While Rico Dowdle will get plenty of touches, expect Young to air it out to his favorite target, rookie wideout Tetairoa McMillan. Let's bet on Young's over 213.5 passing yards prop to close out our best bets on Monday Night Football.
Carolina Panthers vs. San Francisco 49ers Picks
- Carolina Panthers +7.5 (-110)
- George Kittle Anytime Touchdown Scorer (+140)
- Bryce Young O 213.5 Passing Yards (-110)
Best Events to Use the bet365 Bonus Code For November 24
- NFL: Carolina Panthers vs. San Francisco 49ers. 49ers -7.5 and a 49.5 point total. 8:15 p.m. ET kickoff on ESPN.
- College Basketball: Syracuse Orange vs. Houston Cougars. No. 2 Houston faces off against undefeated Syracuse as a -13.5 point favorite with a 139.5 point total. 6 p.m. ET tip-off on TNT.
- NHL: Detroit Red Wings vs. New Jersey Devils. Devils -140 betting favorites at home with a 6.0 goal total. Puck drop at 7 p.m. ET on ESPN+.
- NBA: Cleveland Cavaliers vs. Toronto Raptors. Cavs -2.5 and a 236.0 point total. Tip-off at 7 p.m. ET on Peacock.
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