Best Panthers vs 49ers Player Prop Bet Picks for Monday Night Football Week 12

The Week 12 Sunday Night Football Game brings us the Christian McCaffrey revenge game, as the San Francisco 49ers will face his former team, the Carolina Panthers. The latest NFL Week 12 odds list the 49ers as seven-point favorites in this one. 

If you're looking to spice up this matchup with some NFL Week 12 player props, I've got you covered. Just make sure to use an offer like the bet365 bonus code to make the most of your picks. 

Best BetMGM Panthers vs 49ers Prop Bets: Week 12

BetMGM Sportsbook provides all odds in this section. Use a BetMGM bonus code to maximize your player props. 

Christian McCaffrey – Receiving Yards: OVER 43.5 (-110) 

This is my flat-out favorite prop of the week. Christian McCaffrey is averaging 66.5 receiving yards per game. He has recorded at least 40 receiving yards in all 11 of his appearances this season, reaching at least 50 receiving yards in nine of those games. Now, he'll face his former team, who will be without two starting linebackers. Starting backup LBs against Kyle Shanahan and CMC feels like a death sentence for Carolina. It's possible that this line was set so low because Brock Purdy checks down less than Mac Jones, but I have a hard time seeing CMC finishing with less than 43 receiving yards. If you're feeling frisky, I'd also look into some alt lines, like McCaffrey over 75 yards at +333. 

Best FanDuel Panthers vs 49ers Prop Bets: Week 12

FanDuel Sportsbook provides all odds in this section. Use a FanDuel Sportsbook promo to maximize your player props. 

Bryce Young – Passing Yards: OVER 208.5 (-114) 

Since Week 5, the 49ers have allowed six of their seven opponents to pass for at least 209 yards. The lone exception was Jaxson Dart, who threw for 191 yards but added another 56 yards with his legs. Facing San Francisco is a quarterback's dream; the 49ers can't rush the passer. San Francisco generates pressure at the lowest rate in the league (13.1%) and they're last in the NFL with 12 sacks. Five of those came in the first three weeks, when they had a healthy Nick Bosa. As a seven-point underdog, the game script says Bryce Young should be trailing early and often tonight. Likely to get a lot of attempts against a toothless pass-rush, I think Young has a great shot to reach 209 yards. 

Best DraftKings Panthers vs 49ers Prop Bets: Week 12

DraftKings Sportsbook provides all odds in this section. Use a DraftKings Sportsbook promo to maximize your player props. 

Brock Purdy – Passing Yards: OVER 253.5 (-113) 

If you're playing without two starting linebackers, the 49ers are probably the last team you want to see. Shanahan excels at getting pass-catchers in plus matchups over the middle of the field, so guys like George Kittle, CMC and the hopefully-healthy Ricky Pearsall should be set up to dominate Carolina. Purdy hasn't really played enough games to qualify, but his 262.0 passing yards per game would be the third-best mark among all qualified QBs. He has recorded at least 277 yards in two of his three starts and shouldn't face much resistance from a Panthers team that ranks bottom eight in dropback EPA. 

Maximize Week 12 Props With OddsJam

Simply put, if you want an edge, sign up with OddsJam. It's the gold-standard sports betting tool, thanks to features like the Arbitrage Betting Tool, the Positive EV Betting Tool, and the Promo Finder. This is the best way to make the most of your bets. 

2025 Primetime Player Prop Bet Record 

Each week, I'll post my updated, season-long record for these prop bet picks pieces. Here's my current record (as of Week 12): 

• 42-33 (56.0%)

Where to Bet on Week 12 MNF Props

Below, I've provided a list of the top sportsbooks that offer anytime touchdown betting markets. I've also provided the sign-up bonus at each book, so you can make the most of your prop bets.