San Francisco 49ers vs Los Angeles Rams Odds, Week 10, 2025

#1 C

Jake Brendel: Returning to action in Week 10

Nov 7th

Brendel (hamstring) does not have an injury designation for Sunday's battle against the Rams, Nick Wagoner of ESPN.com reports.

#2 LDE

Keion White: Questionable to face Rams

Nov 7th

White (groin) is listed as questionable for Sunday's game against the Rams, Matt Barrows of The Athletic reports.

#1 LDT

Kalia Davis: Questionable to play Week 10

Nov 7th

Davis (ankle) is listed as questionable for Sunday's game against the Rams, Matt Barrows of The Athletic reports.

#1 MLB

Tatum Bethune: Tagged as questionable Week 10

Nov 7th

Bethune (thigh) is listed as questionable for Sunday's game against the Rams, Matt Barrows of The Athletic reports.

#1 WLB

Dee Winters: Tagged as questionable Week 10

Nov 7th

Winters (knee) is listed as questionable for Sunday's game against the Rams, Matt Barrows of The Athletic reports.

#1 DT2

Alfred Collins: Questionable after two DNPs

Nov 7th

Collins (hip) is listed as questionable for Sunday's game against the Rams, Matt Barrows of The Athletic reports.

#1 LDE

Bryce Huff: Cleared to return Week 10

Nov 7th

Huff (hamstring) does not carry an injury designation into Sunday's game against the Rams, Matt Barrows of The Athletic reports.

#2 WR

Ricky Pearsall: Ruled out for Week 10

Nov 7th

Pearsall (knee) has been ruled out for Sunday's game against the Rams, Matt Maiocco of NBC Sports Bay Area reports.

#2 QB

Mac Jones: Making another start

Nov 7th

Jones will start Sunday's game against the Rams even if Brock Purdy (toe) is active, Nick Wagoner of ESPN.com reports.

#1 QB

Brock Purdy: Won't start even if active

Nov 7th

Purdy (toe) is listed as questionable for Sunday's game against the Rams, but Mac Jones will start even if Purdy is active, Nick Wagoner of ESPN.com reports.

#7 WR

Brandon Aiyuk: Expected to play this year, eventually

Nov 5th

San Francisco head coach Kyle Shanahan said Wednesday that he's "pretty confident" Aiyuk (knee) will play at some point this season, David Lombardi of SFStandard.com reports.

#4 RDE

Mykel Williams: Diagnosed with torn ACL

Nov 3rd

Head coach Kyle Shanahan said Monday that Williams tore his ACL during the fourth quarter of Sunday's 34-24 win over the Giants, Matt Barrows and Dianna Russini of The Athletic report.

#6 WR

Jordan Watkins: Another one-catch outing Sunday

Nov 3rd

Watkins hauled in his only target for 19 yards in Sunday's 34-24 win over the Giants.

#5 WR

Skyy Moore: Busy day returning kicks

Nov 3rd

Moore had one reception for 21 yards while returning five combined kicks for 85 yards in Sunday's 34-24 win over the Giants.

#4 WR

Demarcus Robinson: Continues to disappoint

Nov 3rd

Robinson finished with no receptions (on one target) in Sunday's 34-24 win over the Giants.

#2 RB

Brian Robinson: Best game with San Francisco

Nov 3rd

Robinson took five carries for 53 yards and a touchdown in Sunday's 34-24 win over the Giants. He also returned a kickoff for 41 yards.

#1 K

Eddy Pineiro: Makes six kicks in Week 9 win

Nov 2nd

Pineiro made both of his field-goal attempts and connected on all four of his point-after tries during the 49ers' 34-24 win over the Giants on Sunday.

#3 WR

Kendrick Bourne: Held to two catches in Week 9

Nov 2nd

Bourne caught both of his targets for 34 yards in Sunday's 34-24 win over the Giants.

#1 WR

Jauan Jennings: Scores TD in Week 9 win

Nov 2nd

Jennings caught four of five targets for 41 yards and a touchdown in Sunday's 34-24 win over the Giants.

#1 TE

George Kittle: Four catches in Week 9 win

Nov 2nd

Kittle caught all four of his targets for 32 yards in Sunday's 34-24 win over the Giants.

#1 RB

Christian McCaffrey: Racks up 173 totals yards, two TDs

Nov 2nd

McCaffrey rushed 28 times for 106 yards and a touchdown while catching five of six targets for 67 yards and a touchdown in Sunday's 34-24 win over the Giants.

#2 DT2

Jordan Elliott: Cleared to play Week 9

Nov 2nd

Elliott (ankle) is active for Sunday's game against the Giants, Briana Jeannel of the 49ers' official site reports.

#1 LG

Spencer Burford: Officially cleared for Week 9

Nov 2nd

Burford (knee) is active for Sunday's game against the Giants, Briana Jeannel of the 49ers' official site reports.

#2 FS

Marques Sigle: Healthy scratch Sunday

Nov 2nd

Sigle (coach's decision) is inactive for Sunday's game against the Giants, Briana Jeannel of the 49ers' official site reports.

#1 RDE

Sam Okuayinonu: Good to go Sunday

Nov 2nd

Okuayinonu (ankle) is active for Sunday's matchup with the Giants, Briana Jeannel of the 49ers' official site reports.

#3 LG

Ben Bartch: Ruled out for Week 9

Nov 1st

Bartch (ankle) has been ruled out ahead of Sunday's game against the Giants.

#3 RDE

Yetur Gross-Matos: Lands on IR

Nov 1st

Gross-Matos (knee) was placed on injured reserve Saturday.

#1 SCB

Upton Stout: Cleared for Week 9

Oct 31st

Stout (shoulder) has no injury designation ahead of Sunday's game against the Giants.

#1 LCB

Renardo Green: Posts eight stops vs. Houston

Oct 30th

Green registered eight tackles (four solo) during the 49ers' 26-15 loss to the Texans on Sunday.

#1 RCB

Deommodore Lenoir: Haults in first INT of 2025

Oct 30th

Lenoir registered three tackles (two solo) and one interception during the 49ers' 26-15 loss to the Texans on Sunday.

#3 TE

Jake Tonges: Scores, but plays just five snaps

Oct 29th

Tonges recorded a two-yard touchdown reception on his lone target while playing five of the 49ers' 48 snaps on offense in Sunday's 26-15 loss to the Texans.

#3 RB

Isaac Guerendo: No run on offense this season

Oct 29th

Guerendo played all 10 of his snaps on special teams in Sunday's 26-15 loss to the Texans.

#1 FS

Malik Mustapha: Season-high stops in Week 8 loss

Oct 28th

Mustapha made 12 tackles (six solo) during Sunday's loss to the Texans.

#1 SLB

Luke Gifford: Good to go

Oct 26th

Gifford is active for Sunday's game against the Texans.