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Chargers vs Chiefs Odds, Lines, Spreads & Totals 2025

Chiefs
23.8 Pts
Chargers
20.8 Pts
Friday September 5, 2025 at 8:00 PM ET
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KC
Chiefs Injury Report
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LAC
Chargers Injury Report
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KC
Chiefs Lineup
Inactives
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LAC
Chargers Lineup
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KC
Chiefs News
#2 DT2
Omarr Norman-Lott: Idle with ankle injury
Aug 19th
Norman-Lott (ankle) did not participate in practice Tuesday, Matt McMullen of the Chiefs' official site reports.
#5 RDE
Felix Anudike-Uzomah: Moves to IR
Aug 18th
Anudike-Uzomah (hamstring) was placed on injured reserve by the Chiefs on Monday.
#1 QB
Patrick Mahomes: Expected to start preseason finale
Aug 18th
Head coach Andy Reid relayed Monday that Mahomes and other starters are expected to play in Friday's preseason finale against the Bears, Nate Taylor of The Athletic reports.
#5 WR
Jalen Royals: DNP due to knee tendinitis
Aug 18th
Royals (knee tendinitis) won't practice Monday, Matt McMullen of the Chiefs' official site reports.
#3 WR
Hollywood Brown: Back at practice
Aug 18th
Brown (ankle/foot) has resumed practicing, Matt McMullen of the Chiefs' official site reports.
#4 RB
Brashard Smith: Performs well with five touches
Aug 15th
Smith had three carries for 22 yards and two receptions for 16 yards on as many targets in Friday's 33-16 preseason loss to Seattle.
#2 QB
Gardner Minshew: Plays well in exhibition start
Aug 15th
Minshew completed seven of nine pass attempts for 70 yards and a touchdown in Friday's 33-16 preseason loss to the Seahawks.
#1 RB
Isiah Pacheco: Big gain on only touch Friday
Aug 15th
Pacheco had one reception for 22 yards and did not record a rushing attempt in Friday's 33-16 preseason loss to the Seahawks.
#2 FS
Mike Edwards: Ruled out with hamstring injury
Aug 15th
Edwards won't return to Friday's preseason game against the Seahawks due to a hamstring issue.
#2 RCB
Nohl Williams: Enters concussion protocol
Aug 15th
Williams was placed in concussion protocol during Friday's preseason game against Seattle.
#2 MLB
Jack Cochrane: Hurts knee in exhibition contest
Aug 15th
Cochrane suffered a knee injury and has been ruled out of Friday's preseason clash against the Seahawks.
#2 LCB
Nazeeh Johnson: Exits with shoulder issue Friday
Aug 15th
Johnson has been ruled out from returning to Friday's preseason game against Seattle due to a shoulder injury.
#1 WR
Rashee Rice: Settlement could be reached
Aug 15th
While Rice has a Sept. 30 disciplinary hearing with the NFL scheduled, it's still possible that a settlement could be reached before the season, Tom Pelissero of NFL Network reports.
#3 RG
Ethan Driskell: Not practicing
Aug 13th
Driskell (appendix) did not participate in practice Wednesday, Matt McMullen of the Chiefs' official site of the Chiefs official team site reports.
#2 RB
Kareem Hunt: Nursing quad contusion
Aug 13th
Chiefs coach Andy Reid said Wednesday that Hunt (quadriceps) is dealing with a quad contusion and may not be available for Friday's preseason matchup against Seattle, Nate Taylor of ESPN.com reports.
#6 WR
Tyquan Thornton: Honing in on roster spot
Aug 13th
Thornton is likely to make the Chiefs' 53-man roster, Jesse Newell of The Athletic reports.
#5 RB
Michael Wiley: Signs with Kansas City
Aug 12th
The Chiefs signed Wiley on Tuesday, Matt Derrick of ChiefsDigest.com reports.
#4 SS
Deon Bush: Lands on IR
Aug 11th
The Chiefs placed Bush (Achilles) on injured reserve Monday.
#5 LDE
Janarius Robinson: Goes to IR with broken foot
Aug 11th
Kansas City placed Robinson (foot) on its injured reserve list Monday.
#4 TE
Jared Wiley: One catch in preseason opener
Aug 9th
Wiley (undisclosed) brought in his only target for two yards in the Chiefs' 20-17 preseason loss to the Cardinals on Saturday night.
#1 SCB
Jaylen Watson: Enters concussion protocol
Aug 9th
Watson (concussion) is ruled out for the remainder of Saturday's preseason contest against the Cardinals.
LAC
Chargers News
#3 QB
Trey Lance: Playing one or two series Saturday
Aug 21st
Lance will start Saturday's preseason finale against the 49ers and play one or two possessions, Daniel Popper of The Athletic reports.
#1 RCB
Cam Hart: Recovered from shoulder surgery
Aug 21st
Hart (shoulder) returned to team drills Wednesday, Daniel Popper of The Athletic reports.
#7 WR
Jalen Reagor: Returns to team drills Wednesday
Aug 21st
Reagor (lower body) returned to team drills Wednesday, Daniel Popper of The Athletic reports.
#4 WR
Tre Harris: No team drills Thursday
Aug 21st
Harris (undisclosed) didn't participate in team drills Thursday, Daniel Popper of The Athletic reports.
#1 RG
Mekhi Becton: Practicing in limited capacity
Aug 19th
Becton (undisclosed) was limited to individual drills during Tuesday's training camp practice, Kris Rhim of ESPN.com reports.
#3 RILB
Del'Shawn Phillips: Back at practice
Aug 18th
Phillips (undisclosed) was activated off the active/PUP list by the Chargers on Monday.
#3 TE
Oronde Gadsden: Plays behind Dissly
Aug 16th
Gadsden made one catch on two targets for 12 yards in Saturday's 23-22 preseason loss to the Rams.
#5 WR
KeAndre Lambert-Smith: Hype keeps building
Aug 16th
Lambert-Smith recorded two receptions on six targets for 66 yards in Saturday's 23-22 preseason loss to the Rams.
#2 RB
Omarion Hampton: Plays with starters
Aug 16th
Hampton carried the ball twice for 12 yards in Saturday's 23-22 preseason loss to the Rams.
#1 QB
Justin Herbert: Leads one series
Aug 16th
Herbert completed two of five passes for 46 yards in Saturday's 23-22 preseason loss to the Rams.
#1 WR
Ladd McConkey: Makes brief preseason appearance
Aug 16th
McConkey made one reception on one target for 17 yards in Saturday's 23-22 preseason loss to the Rams.
#2 WR
Quentin Johnston: Suffers concussion
Aug 16th
Coach Jim Harbaugh said Johnston sustained a concussion during Saturday's 23-22 preseason loss to the Rams, Kris Rhim of ESPN.com reports.
#5 LCB
Jordan Oladokun: Goes to IR
Aug 15th
Oladokun (undisclosed) reverted to the Chargers' injured reserve list Friday, per the NFL's transaction log.
#1 RB
Najee Harris: Participates in drills
Aug 12th
Harris (eye) participated in drills with a football Tuesday for the first time during training camp, Kris Rhim of ESPN.com reports.
#1 RDE
Otito Ogbonnia: Plays in Sunday's preseason game
Aug 11th
Ogbonnia played six snaps during Sunday's 27-13 preseason win versus the Saints, Kris Rhim of ESPN.com reports.
#4 RCB
Eric Rogers: Suffers injury Sunday
Aug 10th
Rogers exited Sunday's preseason game against the Saints with an undisclosed injury and didn't return, Kris Rhim of ESPN.com reports.
#2 LCB
Deane Leonard: Suffers leg injury
Aug 10th
Leonard exited Sunday's preseason game against the Saints with an apparent leg injury and did not return, Daniel Popper of The Athletic reports.
#2 TE
Tyler Conklin: Sees one target while starter rests
Aug 10th
Conklin failed to haul in his only target in Sunday's 27-13 preseason win over New Orleans.
#4 RB
Hassan Haskins: Solid showing against Saints
Aug 10th
Haskins took six carries for 33 yards while catching both of his targets for 12 yards in Sunday's 27-13 preseason win over the Saints.
#3 RB
Kimani Vidal: Struggles on six carries
Aug 10th
Vidal rushed six times for 16 yards while failing to bring in his lone target in Sunday's 27-13 preseason win over the Saints.
#2 QB
Taylor Heinicke: Off target in brief start
Aug 10th
Heinicke completed just one of five pass attempts for eight yards and had no rushing attempts in Sunday's 27-13 preseason win over the Saints.
#4 LT
Rashawn Slater: Goes on IR
Aug 9th
The Chargers placed Slater (knee) on injured reserve Saturday.
#1 RT
Trey Pipkins: Bumped up to starting role
Aug 8th
Pipkins is slated to start at right tackle since Rashawn Slater (knee) is out for the season, Ian Rapoport of NFL Network reports.
#1 LT
Joe Alt: Moving to LT after Slater injury
Aug 8th
Alt is expected to shift to left tackle in the wake of Rashawn Slater's season-ending knee injury, Kris Rhim of ESPN.com reports.