Best College Basketball Bets Today: Picks, Odds & Predictions for Saturday, November 22

Top college basketball betting picks are discussed, including multiple Big West teams in action. See the best college hoops plays for Saturday, November 22, 2025.
Best College Basketball Bets Today: Picks, Odds & Predictions for Saturday, November 22
SPECIAL OFFER

Get 10% OFF

Get 10% off any subscription when you subscribe today. Take advantage of our tools and personalized news for the best sports experience. Use promo code RW10.
PROMO CODE RW10

Saturday's college hoops slate is a bit slimmer than usual, as it seems many of the more prolific teams are biding their time until next week's festivities begin. Nonetheless, we've still got a few intriguing matchups on the board.

Top College Basketball Best Bets for Today

For up-to-the-minute updates on injuries, player performance and the transfer portal, head RotoWire's latest college basketball news page or follow @RotoWireCBB on X.

UC Santa Barbara at Nevada

The most significant weak link in this matchup is by far UC Santa Barbara's defense, which ranks 233rd in adjusted efficiency. Nevada ranks in the Top 140 in the nation on both offense and defense, while UCSB ranks 79th offensively.

It's hard to win any game with a porous defense, and Saturday's challenge is even more difficult because Nevada does multiple things very well on offense. The Wolf Pack ranks in the Top 70 of the nation in turnover percentage, offensive rebounding percentage, and free-throw attempt rate. UCSB's defense ranks below the D-1 average in the latter two categories, and it's 124th in turnovers.

UCSB may shoot its way to victory, but I'm betting its leaky defense will allow Nevada to get back in the win column at home. I'm backing the Wolf Pack in this one.

College Basketball Best Bet: Nevada -6.5

Check out the RotoWire CBB betting section for a complete list of the latest college basketball odds across multiple sportsbooks.

San Francisco vs. Minnesota

Both teams dropped their only challenging game of the season so far, so they still have a lot to prove. San Francisco has the edge in overall efficiency, but Minnesota does a few things exceptionally well that shouldn't be overlooked.

The Gophers' defensive efficiency rating could be better, but they're outstanding at snagging boards and holding down the paint. The Gophers have the 14th-highest defensive rebounding percentage in the nation while holding opponents to under 44 percent on two-point attempts, the 35th-best mark in D-1.

At the other end of the court, the Gophers are 26th in offensive rebounding percentage and 16th in free-throw attempt rate. In contrast, USF is 189th in defensive rebounding and 160th in free-throw attempt rate allowed.

San Francisco is another team that tends to live and die by the three-point shot, so anything is possible, but I believe Minnesota's rebounding will be key to a victory. I'm going with the Gophers in this spot.

College Basketball Best Bet: Minnesota +2.5

Check out Caesars Sportsbook this season and use the Caesars Sportsbook promo code for one of the top college basketball betting promos out there.

Northern Iowa at UC Irvine

It's hard to trust the Anteaters.

They've played only three D-1 opponents and have lost to two of them, both outside the Top 100 in KP's overall rankings. And both losses were by margins of seven-plus points. 

UC Irvine is decent on defense, but its offense is severely underwhelming, ranking 249th in adjusted efficiency. 

On the other hand, we have several reasons to trust the Panthers. Last season, they won 14 of 20 conference games, and now they returned 62 percent of their minutes, ranking fourth in the nation for continuity. And unlike their opponent on Saturday, the Panthers are above average offensively, ranking 135th in adj. efficiency. They are also solid defensively, ranking 62nd.

It's possible UC Irvine might bounce back at home and start hitting some shots. Still, I'm not counting on it, given Northern Iowa's immense experience and continuity, not to mention its decent defense. I'm taking the Panthers.

College Basketball Best Bet: Northern Iowa -1.5

Check out Fanatics Sportsbook to bet on National Championship Odds and use the Fanatics Sportsbook promo for a great welcome offer.

 

Saturday College Basketball Best Bets:

Here's a recap of my best college basketball bets for Saturday:

  • Nevada -6.5
  • Minnesota +2.5
  • Northern Iowa -1.5

For up-to-date information on the latest college basketball betting odds and props from multiple sources, check out the college basketball odds page on RotoWire.

ABOUT THE AUTHOR
Graduated from USC in 2012 while interning for ESPN and FOX Sports. Following graduation, I started working full-time for FOX Sports and been there ever since. Been an avid fantasy player for over fifteen years. In addition to my fantasy teams, you'll also find me rooting for the USC Trojans and New York Yankees.
RotoWire Logo

Continue the Conversation

Join the RotoWire Discord group to hear from our experts and other College Basketball fans.

Top News

Tools

NFL Draft Kit Logo

NFL Draft Kit

Fantasy Tools

Don’t miss a beat. Check out our 2025 NFL Fantasy Football rankings.